Orforglipron has now been approved by the FDA.
FDA has now approved Orforglipron
- Thread starter CMA Pooky
- Start date
Not an April fools joke, it would appear.
I'm still waiting for someone to post up "Lilly announces FREE Zepbound Program for all members of the sex work community" with a link to a fake story based around the idea.
I'm still waiting for someone to post up "Lilly announces FREE Zepbound Program for all members of the sex work community" with a link to a fake story based around the idea.
Calm Logic
GLP-1 Specialist
Do you need to be an OnlyFans contributor or can any sex worker join?
Foggy-Hollow
GLP-1 Enthusiast
Eli Lilly’s weight loss pill succeeds in first late-stage trial on diabetes patients; shares jump 14%
The results bring Eli Lilly's pill orforglipron one step closer to becoming a new, needle-free alternative in the booming weight loss and diabetes market.
Beat me to it!
I think a lot of people don’t want to give themselves shots, even if only once per week.
I hope they undercut the sema pill and grab market share.
(Yes I am biased, I now own a little Lilly stock.)
Edit it’s going to be offered world wide (not just US)
And no food/drink restrictions where the Wegovy pill does. I think it’s a good place for them.
"Foundayo"? What image/ lifestyle is that trying to promote/ conjure? At least it's way more fun to say than "orforglipron."
I bet the advertisements will use The Banana Boat song:
Foundayo… Found-ay-ay-o
Daylight come and I feel okay-o
Foundayo… Found-ay-ay-o
Started Foundayo, now the pounds go
Stack that dose and watch it go (Daylight come and I feel okay-o)
Appetite down, metabolism flow (Daylight come and I feel okay-o)
Lift six pounds, seven pounds, eight pounds gone
Feel that energy comin’ on strong
Doctor say, “Hey, you’re doin’ it right”
Scale go down every mornin’, every night
Foundayo… Found-ay-ay-o
Cravings gone and I’m movin’ slow-o
Foundayo… Found-ay-ay-o
Feeling lighter every day though
Snack attacks used to call my name
Now I walk right past without the same
Jeans fit loose, belt notch tight
Confidence comin’ back in sight
Six weeks in and the change is real
Energy up and I love the feel
Friends all ask, “What you been doin’?”
Just smile back like, “Yeah… I’m movin’.”
Etc...
I bet the advertisements will use The Banana Boat song:
Foundayo… Found-ay-ay-o
Daylight come and I feel okay-o
Foundayo… Found-ay-ay-o
Started Foundayo, now the pounds go
Stack that dose and watch it go (Daylight come and I feel okay-o)
Appetite down, metabolism flow (Daylight come and I feel okay-o)
Lift six pounds, seven pounds, eight pounds gone
Feel that energy comin’ on strong
Doctor say, “Hey, you’re doin’ it right”
Scale go down every mornin’, every night
Foundayo… Found-ay-ay-o
Cravings gone and I’m movin’ slow-o
Foundayo… Found-ay-ay-o
Feeling lighter every day though
Snack attacks used to call my name
Now I walk right past without the same
Jeans fit loose, belt notch tight
Confidence comin’ back in sight
Six weeks in and the change is real
Energy up and I love the feel
Friends all ask, “What you been doin’?”
Just smile back like, “Yeah… I’m movin’.”
Etc...
The article mentions that they will match the price of the Wegovy/Sema pill in the States at the lowest dosage for $149 a month. The highest dosage will cost up to $349 a month.Eli Lilly’s weight loss pill succeeds in first late-stage trial on diabetes patients; shares jump 14%
The results bring Eli Lilly's pill orforglipron one step closer to becoming a new, needle-free alternative in the booming weight loss and diabetes market.www.cnbc.com
Beat me to it!
I think a lot of people don’t want to give themselves shots, even if only once per week.
I hope they undercut the sema pill and grab market share.
(Yes I am biased, I now own a little Lilly stock.)
Edit it’s going to be offered world wide (not just US)
And no food/drink restrictions where the Wegovy pill does. I think it’s a good place for them.
What is the cost of manufacturing a month's supply -- $5.00, maybe. Options are nice. Options people can afford are better. I will get excited when there is competition from more companies.
jakexb
Recently Joined
🚫No Source Discussion🚫
Good to see this! My guess is this will prompt a lot more interest around here. I think a lot of people will be interested just due to oral compounds being easier to verify safety (don’t have the same sterility, endotoxin concerns)
Calm Logic
GLP-1 Specialist
To reduce GI sides, the official doses are lower than the phase 3 trials:
I haven't seen any grey/Chinese tablets below 6 mg, and I only see 12 mg usually. Average cost is about $200 for a hundred 12-mg tablets (14 to 19 cents per mg). They can be cut, but they are small to begin with (at least with Uther).
For me as a hoarder, the biggest problem is the tablets may not last as long as kits, with Uther saying three years before expiration for the tablets. And grey pricing is not exciting so far and hasn't really changed since starting last fall or so.
The main benefit for stacking or aggressive titration is the shorter half life (24 to 36 hours for most/fast metabolizers). But EOD (every other day) dosing may be best to prevent sides, if not splitting the tablets. Third or forth day can be rougher than the first, from what I remember taking it.
Gemini said:
I haven't seen any grey/Chinese tablets below 6 mg, and I only see 12 mg usually. Average cost is about $200 for a hundred 12-mg tablets (14 to 19 cents per mg). They can be cut, but they are small to begin with (at least with Uther).
For me as a hoarder, the biggest problem is the tablets may not last as long as kits, with Uther saying three years before expiration for the tablets. And grey pricing is not exciting so far and hasn't really changed since starting last fall or so.
The main benefit for stacking or aggressive titration is the shorter half life (24 to 36 hours for most/fast metabolizers). But EOD (every other day) dosing may be best to prevent sides, if not splitting the tablets. Third or forth day can be rougher than the first, from what I remember taking it.
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Cypress
GLP-1 Novice
🚫No Source Discussion🚫
That took some time roflmao😀
FartfulCodger
GLP-1 Enthusiast
I once was lost... but now I'm FOUNDAYO!
rkl123
GLP-1 Enthusiast
I would not put stock in the three year thing. Almost all dry pills stay good years after "expiration".
Calm Logic
GLP-1 Specialist
True, thanks. I could also vacuum seal my second pill bottle, if I don't plan on using it this decade. But I will probably use them all sooner than that, like as a shorter-term sema for stacking.
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RadicalCrimson
GLP-1 Apprentice
The Phase 2 trials showed that the most effective dose for weight loss was actually 24mg: https://www.thelancet.com/cms/10.10...c57-8753-d2b4ce7c13c9/main.assets/gr2_lrg.jpg
lessthanhalf
GLP-1 Specialist
I realise a lot of people are not comfortable with injecting themselves, but a near painless injection once a week for more weight loss and less side effects for tirzepatide ( or reta ) would seem to be a better option than any of the oral GLP's. Putting up with more nausea or vomiting does not seem like a great trade off to avoid an injection.
I do appreciate the short (relative to the popular injectables) half-life. If someone desired to cycle off having their receptors activated at supraphysiological levels 24/7 for a week or two periodically, it would enable a person to more easily do that (VS the 2-3 months that the injectables would typically take).
To be clear that's not some misguided receptor desensitization notion, but simply an observation that there may be bodily systems that only activate when GLP-1 signaling is low and perhaps having those systems forever suppressed may come with a cost that we're not aware of.
To be clear that's not some misguided receptor desensitization notion, but simply an observation that there may be bodily systems that only activate when GLP-1 signaling is low and perhaps having those systems forever suppressed may come with a cost that we're not aware of.
K2UGA
GLP-1 Apprentice
Scaramouche, Scaramouche, will you do the Foundayo!
NIGLP89user
GLP-1 Novice
🚫No Source Discussion🚫
While this may be different The US army under the Shel Life Extention Programme have tested solid medicications that are years past the expiration date and they have been actually pretty good
Obviously things may be different, but usually manufacturers put a large margin for error for expiration dates. It's a risk, but it's up to everyone to check the risk
K2UGA
GLP-1 Apprentice
Interesting that there is still noone reliably selling this. I have heard that there issues trying to recreate it properly.
Calm Logic
GLP-1 Specialist
You won't find orfo on most pricelists.
But it is available both domestically and internationally from a few select vendors.
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jakexb
Recently Joined
🚫No Source Discussion🚫
I got it twice, once tablet, once liquid. Neither are available anymore. Worked really well though, hope to see it come back in a reputable way.
