FDA says semaglutide is no longer in shortage

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Shares of Hims & Hers tumble 26% after FDA says semaglutide is no longer in shortage
Published Fri, Feb 21 2025, 12:56 PM EST
  • The FDA said the shortage of semaglutide injection products such as Novo Nordisk’s Ozempic and Wegovy has been resolved.
  • The agency said it will start taking action against compounders, which are allowed to produce custom-made alternatives to brand-name drugs during shortages, for violations in the next 60 to 90 days.
  • The FDA said Friday that it will start taking action against compounders for violations in the next 60 to 90 days, depending on the type of facility, in order to “avoid unnecessary disruption to patient treatment.”
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In other news, my research for 🇨🇳 vendors intensifies...
 
The Ozempic Shortage Is Over
By Kate Knibbs and Emily Mullin, Feb 21, 2025 10:58 AM
www.wired.com

The Ozempic Shortage Is Over

The semaglutide shortage has officially ended in the US—which means the GLP-1 drug industry is about to undergo massive changes.
www.wired.com www.wired.com
At the end of October, the FDA changed the status of all dosages of Ozempic and Wegovy to “available,” signaling that the end of the official shortage was likely in sight. It took until today, nearly four months later, for regulators to conclude that the drug was widely available enough to remove it from the shortage list.

The FDA is giving “503A” compounders, typically state-licensed pharmacies or physician compounders that run smaller operations, until April 22 to cease producing the drug. It is giving “503B” compounders, which are larger outsourcing facilities that follow stricter manufacturing guidelines, until May 22.
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We'll see how long it lasts. If everyone on compound all of a sudden gets a legit rx, they're going to be on shortage again very quickly.

I think the big issue will be a pharmacies ability to keep it in stock; their fridges tend to be rather small.
 
chmuse said:
We'll see how long it lasts. If everyone on compound all of a sudden gets a legit rx, they're going to be on shortage again very quickly.

I think the big issue will be a pharmacies ability to keep it in stock; their fridges tend to be rather small.
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If it can be ordered regardless of how long it takes it will be considered available and I don't foresee them hitting the shortage list again.

Pharmacy's don't need to have the product available, just the ability to order it. Many of the people reporting the shortage to the FDA were expecting walk-in coolers behind the counter full of all the doses in multiples refreshed like a Golden Corral Buffet. They left the pharmacy empty-handed and were greeted by an Internet with links all over to report to the FDA.

I'm not defending or excusing Lilly/Novo. Just saying I'm on many scripts that aren't stocked and have to be ordered.
 
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I am more concerned with them all selling 6 month supplies in prefilled syringes. Seems a bit risky for harm.
 
nonyabizznez said:
If it can be ordered regardless of how long it takes it will be considered available and I don't foresee them hitting the shortage list again.

Pharmacy's don't need to have the product available, just the ability to order it. Many of the people reporting the shortage to the FDA were expecting walk-in coolers behind the counter full of all the doses in multiples refreshed like a Golden Corral Buffet. They left the pharmacy empty-handed and were greeted by an Internet with links all over to report to the FDA.

I'm not defending or excusing Lilly/Novo. Just saying I'm on many scripts that aren't stocked and have to be ordered.
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Fair enough. It'll be interesting to see how it plays out. I've seen that some pharmacies won't even stock it because patients go feral when they can't get it on time.
 
chmuse said:
Fair enough. It'll be interesting to see how it plays out. I've seen that some pharmacies won't even stock it because patients go feral when they can't get it on time.
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Yeah, I was trying a soft response since we're being accused of being condescending Jack-offs... But since you're opening the gate...

I alluded to it with the Golden Corral reference. Some pharmacists have said GLP-1 customers are the absolute worst, worse than addicts being denied sched 2 drugs. They clog their phones, berate associates and confront customers who are having scripts filled after ordering the conventional way. They've had to modify their phone procedures and obscure windowed visi coolers from customer view to prevent customers seeing GLP boxes in the cooler awaiting customer pickup. Some demand substitutions based on inventory in dosage and even brand Mounjaro for Zepbound. Some have multiple scripts and berate the pharmacist or tech to contact their insurance despite a line and a known outcome.

I live nextdoor to my pharmacy where I get everything except Mounjaro. I get that mail order from Centerwell (Humana) because I don't want to add to their stress and I've seen that thanks to PBMs there's no profit for them anyway.

I managed to get all that out w/o saying "Karen"
 
touringsedan said:
I am more concerned with them all selling 6 month supplies in prefilled syringes. Seems a bit risky for harm.
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Who's doing that? I know some spas were doing that monthly. Are you talking about the script injection devices? (that have BUDs over a year out)
 
Morbius said:
There is a brief discussion of this on Reddit.

https://www.reddit.com/r/medicine/comments/1iv6y8h/fda_declares_end_to_wegovy_and_ozempic_shortage

So far no one seems sure what to expect for the future of compounding.
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Semaglutide belongs to Novo for the short term and Tirzepatide belongs to Lilly for the long term (many years).

There will be no more compounding. Not with an additive not for a unique dose. Telehealth will try to sell you something else. Already the much reduced advertising emphasizes blue pills and hair growth over weight loss.
 
nonyabizznez said:
Yeah, I was trying a soft response since we're being accused of being condescending Jack-offs... But since you're opening the gate...

I alluded to it with the Golden Corral reference. Some pharmacists have said GLP-1 customers are the absolute worst, worse than addicts being denied sched 2 drugs. They clog their phones, berate associates and confront customers who are having scripts filled after ordering the conventional way. They've had to modify their phone procedures and obscure windowed visi coolers from customer view to prevent customers seeing GLP boxes in the cooler awaiting customer pickup. Some demand substitutions based on inventory in dosage and even brand Mounjaro for Zepbound. Some have multiple scripts and berate the pharmacist or tech to contact their insurance despite a line and a known outcome.

I live nextdoor to my pharmacy where I get everything except Mounjaro. I get that mail order from Centerwell (Humana) because I don't want to add to their stress and I've seen that thanks to PBMs there's no profit for them anyway.

I managed to get all that out w/o saying "Karen"
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Yeah, I was also tempering my words. 😅 We get people coming to the ER because their pharmacy was out and they want an emergency refill. Absolutely, 100% serious.
 
Morbius said:
Next question is... Will the people cut off from compounding realize there is a grey market, and would an influx of noobs be bad for seasoned peptide pros like ourselves?
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I found grey while debating buying compound and decided to skip the middleman, so it's not like it's all that hidden that it's an option.
 
Morbius said:
Next question is... Will the people cut off from compounding realize there is a grey market, and would an influx of noobs be bad for seasoned peptide pros like ourselves?
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Yes

Unless you're over seasoned... I've got more vials in my freezer than ice cubes and I've got a big ice bin!
 
Morbius said:
Next question is... Will the people cut off from compounding realize there is a grey market, and would an influx of noobs be bad for seasoned peptide pros like ourselves?
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I think most people cut off from compound will not go grey, at least on a percentage basis. Still, even if 5% go grey, that is a lot of desperate people who will flood in and have no idea what they are doing. STG is a great resource for them, but they are already struggling with 7,700 people. The message boards are almost unreadable. I don't know how they will manage another 50,000 people, or more.
There really aren't the resources in the community to deal with the upcoming tidal wave. I fear that some people are really going to hurt themselves, and that will draw attention to the grey market and give all of us a bad name.
 
Morbius said:
I'm not even sure what I need down the road but I think I am ordering more sema in the next few days... I have the freezer space.
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Sema has to be one of the best deals out there. The most juice for the squeeze. If it were the only GLP we'd all be on it. I'm on Tirz but got plenty of Sema as rainy day plan B.

Back when you saw formerly heavy celebrities thinned out did you ever think you can get the same shizz at $10 per month at maximum dose?

I tell ya...
 
nonyabizznez said:
Sema has to be one of the best deals out there. The most juice for the squeeze. If it were the only GLP we'd all be on it. I'm on Tirz but got plenty of Sema as rainy day plan B.

Back when you saw formerly heavy celebrities thinned out did you ever think you can get the same shizz at $10 per month at maximum dose?

I tell ya...
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Sema is a poor man’s GLP at this point. Better options are available.
 
chmuse said:
Clearly not. But this is a hell of a lot better than alcohol and nicotine. I'm trying to be better about it.
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I hope my message didn't come across as anything but a joke, I keep coming back to this place because of your sense of humor. You're a joy.
 
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Wheatthins said:
I hope my message didn't come across as anything but a joke, I keep coming back to this place because of your sense of humor. You're a joy.
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Hey, I gave you a laugh react. 🤷‍♀️ You're not wrong. Objectively, it's the truth.
 
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Wheatthins said:
I hope my message didn't come across as anything but a joke, I keep coming back to this place because of your sense of humor. You're a joy.
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Oh thank Gawd! I was posting on a contentious thread that disappeared then saw your post and thought Oh Shit! The wheels are coming off the bus!

Thx for clearing that up. It is a new day and I hope y'all enjoy it!
 
nonyabizznez said:
Oh thank Gawd! I was posting on a contentious thread that disappeared then saw your post and thought Oh Shit! The wheels are coming off the bus!

Thx for clearing that up. It is a new day and I hope y'all enjoy it!
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Did I miss a good thread?
 
chmuse said:
Did I miss a good thread?
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What sux is I was doing my usual... posting a knee jerk response before reading the whole thread. It started out with a newbie plugging a vendor and I had spelled out what a ripoff they were and he came back trollish thinking I was a troll and then someone called someone a lying whore bitch then threw her drink and flipped the table!

Oh wait, that's my Real Housewives and GLP forum colliding again... These damn fibers and oligomers!

I reached out to the guy through DM with info nobody would find unhelpful so hopefully he'll see our motives here and make like a Chinese Vendor, rebrand and come back. Or not.
 
nonyabizznez said:
What sux is I was doing my usual... posting a knee jerk response before reading the whole thread. It started out with a newbie plugging a vendor and I had spelled out what a ripoff they were and he came back trollish thinking I was a troll and then someone called someone a lying whore bitch then threw her drink and flipped the table!

Oh wait, that's my Real Housewives and GLP forum colliding again... These damn fibers and oligomers!

I reached out to the guy through DM with info nobody would find unhelpful so hopefully he'll see our motives here and make like a Chinese Vendor, rebrand and come back. Or not.
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Oh I know who you mean 🙃 I'm surprised he was still able to delete the thread after this long. Maybe bee intervened. Unless I'm getting all these new people mixed up. That would make sense, since I'm such a jerkoff.
 
chmuse said:
Oh I know who you mean 🙃 I'm surprised he was still able to delete the thread after this long. Maybe bee intervened. Unless I'm getting all these new people mixed up. That would make sense, since I'm such a jerkoff.
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You gave my response to him a thumbs up fwiw.
The first item at the vendor's website was 10mg T10 for $85. There's a vendor here with a kit at $70. Kind of hard to make the "onesie" for testing argument when said onesie is more than an entire kit.

I wish I read it though... It's been eviscerated... Not even any mouse droppings.
 
nonyabizznez said:
You gave my response to him a thumbs up fwiw.
The first item at the vendor's website was 10mg T10 for $85. There's a vendor here with a kit at $70. Kind of hard to make the "onesie" for testing argument when said onesie is more than an entire kit.

I wish I read it though... It's been eviscerated... Not even any mouse droppings.
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Yes I liked it for that reason. Poor OP was asking about trying single vials of other stuff. Oops.

I'll be nice even if he doesn't rebrand. I feel bad.
 
nonyabizznez said:
Yeah, I was trying a soft response since we're being accused of being condescending Jack-offs... But since you're opening the gate...

I alluded to it with the Golden Corral reference. Some pharmacists have said GLP-1 customers are the absolute worst, worse than addicts being denied sched 2 drugs. They clog their phones, berate associates and confront customers who are having scripts filled after ordering the conventional way. They've had to modify their phone procedures and obscure windowed visi coolers from customer view to prevent customers seeing GLP boxes in the cooler awaiting customer pickup. Some demand substitutions based on inventory in dosage and even brand Mounjaro for Zepbound. Some have multiple scripts and berate the pharmacist or tech to contact their insurance despite a line and a known outcome.

I live nextdoor to my pharmacy where I get everything except Mounjaro. I get that mail order from Centerwell (Humana) because I don't want to add to their stress and I've seen that thanks to PBMs there's no profit for them anyway.

I managed to get all that out w/o saying "Karen"
Click to expand...
That is the absolute truth. My pharmacy "normally" has stock on Ozempic or gets it for me in a few days. I established that I take it for A1C early on. The pharmacist put a note in my file ... the techs don't give me a hard time anymore. I used to hate the eyerolls when I would ask for my script at the drive thru.. especially when there were shortages. I would tell them I was taking it for A1C and not weight loss and they would breathe a sigh of relief... the pharmacist told me they absolutely hare dealing with the weight loss crowd as the are insufferable.
 
jimbothigpen said:
This is actually one of the reasons I'm seriously considering subbing in some sema in place of tirz. If anything, my smoke breaks have become more frequent lately, after cutting down to close to a 1/2 pack/day pre-GLP-1.
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I'm almost done with my last bottle of salt nic. I've been cutting it with zero nicotine juice and trying to make it last as long as possible. I promised myself when it was done, I wouldn't replace it. (Don't hold me to that.)
 
chmuse said:
Tell him I love him and I'm sorry!
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You can tag him 🤷🏻‍♂️ @jasonlovespeptides

I felt bad too and turns out he's not the only one mentioning that vendor... Iz juss hypersensitivity to the shills...

When he spends more time here he'll know exactly where we were coming from (good intentions).
 
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nonyabizznez said:
You can tag him 🤷🏻‍♂️ @jasonlovespeptides

I felt bad about too and turns out he's not the only one mentioning that vendor... Iz juss hypersensitivity to the shills...

When he spends more time here he'll know exactly where we were coming from (good intentions).
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@jasonlovespeptides I'm sorry! I didn't mean it! Come back, I'll be nice! Don't leave us!

 
raw_oyster_eater said:
what the hell. i didn't get shit for valentines.
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1740360883078.gif
 
nonyabizznez said:
Yeah, I was trying a soft response since we're being accused of being condescending Jack-offs... But since you're opening the gate...

I alluded to it with the Golden Corral reference. Some pharmacists have said GLP-1 customers are the absolute worst, worse than addicts being denied sched 2 drugs. They clog their phones, berate associates and confront customers who are having scripts filled after ordering the conventional way. They've had to modify their phone procedures and obscure windowed visi coolers from customer view to prevent customers seeing GLP boxes in the cooler awaiting customer pickup. Some demand substitutions based on inventory in dosage and even brand Mounjaro for Zepbound. Some have multiple scripts and berate the pharmacist or tech to contact their insurance despite a line and a known outcome.

I live nextdoor to my pharmacy where I get everything except Mounjaro. I get that mail order from Centerwell (Humana) because I don't want to add to their stress and I've seen that thanks to PBMs there's no profit for them anyway.

I managed to get all that out w/o saying "Karen"
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U could more easily hone ce up a glp1 drug for a few days than Adderall.
 
yelloeyes said:
That is the absolute truth. My pharmacy "normally" has stock on Ozempic or gets it for me in a few days. I established that I take it for A1C early on. The pharmacist put a note in my file ... the techs don't give me a hard time anymore. I used to hate the eyerolls when I would ask for my script at the drive thru.. especially when there were shortages. I would tell them I was taking it for A1C and not weight loss and they would breathe a sigh of relief... the pharmacist told me they absolutely hare dealing with the weight loss crowd as the are insufferable.
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I mean, it sucks that customers are like that, but it is a weight loss drug. You shouldn't have to clarify what you're taking it for just so they won't treat you like people who behave like assholes. And those people shouldn't behave like assholes, but as we all know, assholes gonna asshole.
 
What they really need to do is find a way to sell it that doesn't require refrigeration, AND increase production to keep it out of shortage. I'm thinking like, lyophilized powder in one chamber, bac water in another, pull the tab and they mix right before administering. Obviously someone more creative and science-y than me could come up with something better, but increasing production, and finding a way to make it shelf stable so pharmacies can stock more of it, would go a long way. Especially once semaglutide goes generic and the prices drop.
 
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