FOXO4-DRI

[trojanpeptide]

TY

for this. I will incorporate some additional FOX)$ known unknown risks in my notes!

u know, theres a guy, Steve Combi, who says he uses FOXO4-DRI, I think maybe a lot ? idk for sure, might be worth reading his threads. Here's a link.

 

[AlexSilver]

u know, theres a guy, Steve Combi, who says he uses FOXO4-DRI, I think maybe a lot ? idk for sure, might be worth reading his threads. Here's a link.

Isn't that whole thread really about how maraviroc does a similar thing? I mean that's a lot to read, will take me some time.

 

[AlexSilver]

u know, theres a guy, Steve Combi, who says he uses FOXO4-DRI, I think maybe a lot ? idk for sure, might be worth reading his threads. Here's a link.

Steve Combi is currently dosing himself with Rapamycin. Seems a lot scarier than good ol D-Retro-Inverso.

 

[trojanpeptide]

Isn't that whole thread really about how maraviroc does a similar thing?

similar, not exact, but yea, nice thread.

Steve Combi is currently dosing himself with Rapamycin. Seems a lot scarier than good ol D-Retro-Inverso.

not really, there's a lot more known about rapamycin then foxo4-dri. I've read a few of his messages; I get the impression that he's tried a lot of meds/peptide.
He explains his dosages in this link. (24mg over a 3 day = 8.0mg per day Twice a year).

 

[Researcher6076]

similar, not exact, but yea, nice thread.

not really, there's a lot more known about rapamycin then foxo4-dri. I've read a few of his messages; I get the impression that he's tried a lot of meds/peptide.
He explains his dosages in this link. (24mg over a 3 day = 8.0mg per day Twice a year).

I replied to a post there, trying to get in touch with him. I want to understand how he got to his protocol.

 

[trojanpeptide]

I replied to a post there, trying to get in touch with him. I want to understand how he got to his protocol.

yes I saw that. He should be on this site too !

But honestly, back to the original query, where do we source authentic foxo4-dri from vendors? I get a lot of different answers depending who you ask.

 

[Researcher6076]

Uther has it. Bella at HK has it. Lydia at ZJ has it, which would probably be my go to. I think I would pay to test this one. 🙂 prices are not terrible considering this is a hard one to make.

 

[Researcher6076]

So if you were thinking of doing this... would you do it when you were still agining well? Or would you wait until you were showing more functional signs of aging?

 

[trojanpeptide]

So if you were thinking of doing this... would you do it when you were still agining well? Or would you wait until you were showing more functional signs of aging?

I would do it now, in my mid 50s, but I have a lot of 'damaged tissue' as is.

 

[trojanpeptide]

It looks like we got those guys started up again in that thread I posted. Good source of information. Now I really want to order some FOXO4-DRI.

 

[Researcher6076]

I started a new thread over there and we will see where it goes.

 

[trojanpeptide]

imma update this thread for the good of the community.

FOXO4-DRI appears to be available from a number of our favorite vendors under the code F410 (ex. Homopeptide sells it). I still have not been able to acquire a Janoshik CoA from any of them, however we can rely on the original CoA that I was provided since they all have the same product code.

Also here is the sequence breakdown from the CoA I originally posted:


As you can see, the F410 product contains an inverse HIV-TAT tag to facilitate membrane mobilization.

 

[Researcher6076]

imma update this thread for the good of the community.

FOXO4-DRI appears to be available from a number of our favorite vendors under the code F410 (ex. Homopeptide sells it). I still have not been able to acquire a Janoshik CoA from any of them, however we can rely on the original CoA that I was provided since they all have the same product code.

Also here is the sequence breakdown from the CoA I originally posted:
View attachment 21942

As you can see, the F410 product contains an inverse HIV-TAT tag to facilitate membrane mobilization.

And I verified that that is the molecular sequence that Janoshik tests for. Since it's a reasonably large peptide , I know that I would buy two kits and I would test a vial if I was going to use it. It takes one and a half kits for a single treatment. Not saying I changed my position that I think it's a very dangerous peptide to test. But I might just get a couple of hits get the test done and put this in the freezer so I've got it.

 

[jason370]

I am sharing what I've got for research summaries for about two dozen different peptides. I'm not telling anyone what to do. Just sharing the information, I put together for myself. The perfect is the enemy of the good, these could be better, but instead of obsessing to clean them up I’m just sharing.

Please, if you find errors or missing information let me know. No ego here, I make mistakes.

Please read the full disclaimer in README.pdf . And here is the folder link Share containing these file:

5 Amino 1q.pdf
bpc-157.pdf
CJC 1295 NODAC + Ipamorelin.pdf
Epitalon for sleep.pdf
Epitalon plus Thymalin.pdf
Epitalon plus Vilon.pdf
FOXO4-DRI.pdf
GHK-cu.pdf
GLOW.pdf
Glutathione.pdf
kpv.pdf
MOTS-C.pdf
NAD+.pdf
Prostamax.pdf
retatrutide.pdf
Selank.pdf
Semax.pdf
SS-31.pdf
tb-500.pdf
Tesamorelin.pdf
Thymosin Alpha 1.pdf
tirzepatide.pdf
Vesugen.pdf
vilon.pdf

If it isn't too much to ask, do you think you could perform a public service and just write "good, bad, or unclear" next to each peptide you listed. I would love to know the short version of what you've learned. Surely I cant be alone in this interest.

Thanks in advance!

 

[Muffyflowers]

I've been reading over the document, and agree, yes there are risks, but there are also many benefits. Everything I read here regarding (some of) the risks would also apply to other senolytics, such as D&Q and maybe fisetin. Also a matter of dosages; start small go slow, clear a little, not a lot, seems like a good strategy.
The biggest concern I have regarding FOXO4-DRI is that the peptide needs to cross two membranes and that this was achieved in the mouse studies by, iirc, fusing the peptide to an HIV vector. It was also delivered intravenously, which I won't be doing that lol.

Although, it's been difficult for me to acquire years, and the years have taught me to listen to the Universe. I will start slowly with D&Q. Maybe even D&Q&F(isetin).

You could always try some dry fasting. Excellent for ridding the body of senescent cells, also huge stem cell and other benefits. The Russians have been doing it for I think over 100 years. I’ve done 4.5 days but am wanting to do 7-9 days sometime soon.

 

[trojanpeptide]

You could always try some dry fasting

I was planning to start with a milder Fisetin treatment this week, and then D&Q in a couple more weeks afterwards. I do have other health issues, which is what drew me into the peptide world in the first place. I don't think I should be fasting as I've been on retatrutide since last Sep and am getting to my physical limits with regards to weight loss. But thank you for the mention; whatever helps us as a community is

 

[ktg123]

Yes! Those kinds of skin patchrs are exactly the kinds of issues foxo4-dri should help. How. Many mg each day? How many days? Did you alternate days?

Sorry, I missed this question.
Looking back at my notes, I've taken fox 3 times in the last 18 months.
Each time I started at 1mg/day and worked up to 2mg/day over a week. Then I took 2mg/day for 1-2 weeks.

 

[Researcher6076]

Sorry, I missed this question.
Looking back at my notes, I've taken fox 3 times in the last 18 months.
Each time I started at 1mg/day and worked up to 2mg/day over a week. Then I took 2mg/day for 1-2 weeks.

Your protocol and dose are so different than the animal studies. Can you share how you choose it?