GLP-1 Drugs Don't Fix Everything

[Fisherman2356]

I've used Reta to help lose over 80 lbs, and according to my scans, during the Reta phase of my cut, I actually gained almost 6 lbs of lean muscle mass.

For the lazy ones (like me LOL) that don't like exercise I think doing HGH helps retain muscle mass. I had lost some muscle while on Tirze and Reta (together with losing fat) but after couple months on 3IU hgh five days a week it seems I gained it all back. Plus, I had also lost some strength and now I'm at par to where I was before GLP1's. The thing thou is it seems you lose less weight if you do HGH while doing GLP1's, that's at least my experience. Perhaps the upside to that is you losing less weight because you are not losing any muscle? Nevertheless it could be a good idea to start HGH after you have reached or are close to reaching your goal weight.

 

[50ShadesGreyMarket]

There have been a variety of scholarly articles extolling the virtues of GLP-1 drugs for treating a variety of ailments other than just diabetes and weight loss. Here is a rare negative article on GLP-1 drugs. It concludes that while people lose weight on GLP-1 drugs, their aerobic fitness appears not to improve.

Liu, et al. (2025). Incretin Receptor Agonism, Fat-free Mass, and Cardiorespiratory Fitness - A Narrative Review. J. Clin. Endocrinology & Metabolism 110(10), 2709-2717.

This further supports the notion that there is no magical treatment that doesn’t require some effort on the part of the individual. If people aren’t willing to change their lifestyle, they will never achieve optimal health. Sure, you can become catabolic and lose a ton of fat, muscle and possibly bone density given enough time but if you want to fix your metabolism, increase strength and endurance which will lead to fewer ailments as you age, you have to increase nutrients and resistance training.

I’ve seen some insane cases where someone insisted GLP’s made their hair fall out, lead to skin problems, salivary stones, dental erosion, the list goes on - these are caused by choices, like not drinking enough water, not getting enough nutrient dense foods and refusing to Increase protein and build muscle. The body building community is doing great on these but they have a completely different approach. They use it as a supplement to a strict regimen, not a replacement for healthy choices.