Glp1 dependence?

[byefatlicia]

We all know there is a great possibility that we regain weight when stopping Glp1s. But here's my question. How about those who started out not obese? Those who weren't unhealthy to begin with? The folks with the nagging 20 or 30 pounds to shed. Or the body builders using Glps to cut? Will they have a hard time with hunger and food noise after stopping beyond what was normal for them before starting?
Will they find themselves needing to be in long term maintenance like many of us have already resolved to be?

 

[Super Trips]

all those "Reta" fitness nuts on FB claiming peptides work only had to lose a little weight but act as if they lost 100lbs and understand real weight loss journeys and the real issues at hand

 

[Habibibi]

We all know there is a great possibility that we regain weight when stopping Glp1s. But here's my question. How about those who started out not obese? Those who weren't unhealthy to begin with? The folks with the nagging 20 or 30 pounds to shed. Or the body builders using Glps to cut? Will they have a hard time with hunger and food noise after stopping beyond what was normal for them before starting?
Will they find themselves needing to be in long term maintenance like many of us have already resolved to be?

They should plan to stay on them since the data is very clear on what happens when GLP1 is stopped. I've seen people trying to get off by using other stuff like tesofensine to maintain weight loss, and that looks like a dumb idea.

Anyway, people don't expect you to get off statins once your cholesterol is lowered by them, so I don't see what the big deal is for GLP1s

 

[byefatlicia]

They should plan to stay on them since the data is very clear on what happens when GLP1 is stopped. I've seen people trying to get off by using other stuff like tesofensine to maintain weight loss, and that looks like a dumb idea.

Anyway, people don't expect you to get off statins once your cholesterol is lowered by them, so I don't see what the big deal is for GLP1s

So, I guess the reason for the question is, should I discourage friends that need to lose 20 or 30 lbs from taking Glp1s? Is it irresponsible to tell them "yeah, This stuff is great. You should definitely do it." If they are gonna have to stay on it forever?

 

[HumanusExMachina]

I only needed to lose 25-30 lbs. Before going on a GLP1, absolutely nothing worked to trim even two pounds -- fasting, exercise, diet changes.... In 4 months on a GLP1, I'm almost down to my target weight. Do I plan on going off the GLP1 once I hit my target? Nope.

I'd say it depends on whether your friends can lose the weight -- and keep it off -- using some "normal" method, then go that way. Otherwise, I don't think it matters how much weight you need to lose if a GLP1 is the only thing that works for you.

 

[Habibibi]

So, I guess the reason for the question is, should I discourage friends that need to lose 20 or 30 lbs from taking Glp1s? Is it irresponsible to tell them "yeah, This stuff is great. You should definitely do it." If they are gonna have to stay on it forever?

You can do both : tell them it's great, and tell them what happens when they get off them. Regardless of how many pounds they need to lose.

 

[Slogger]

I only needed to lose 25-30 lbs. Before going on a GLP1, absolutely nothing worked to trim even two pounds -- fasting, exercise, diet changes.... In 4 months on a GLP1, I'm almost down to my target weight. Do I plan on going off the GLP1 once I hit my target? Nope.

I'd say it depends on whether your friends can lose the weight -- and keep it off -- using some "normal" method, then go that way. Otherwise, I don't think it matters how much weight you need to lose if a GLP1 is the only thing that works for you.

My story exactly- and I’m staying on tirz as long as I can!

 

[Mr. Blonde]

Just my opinion. I think that the majority of weight loss can be kept off provided that lifestyle changes were made. Keep eating healthy and exercising (whatever that means to you).

Of course the extra metabolic benefits will be lost so some weight gain would be natural to include inflammation weight.

These are just my thoughts, not a doctor, but did bang a nurse one time.

 

[Monte2024]

I’m as interested in sustaining the improvement in health markers as I am the weight loss. Hoping reduced dosage for long term maintenance + continued lifestyle changes will work.

 

[yrrdead]

So, I guess the reason for the question is, should I discourage friends that need to lose 20 or 30 lbs from taking Glp1s? Is it irresponsible to tell them "yeah, This stuff is great. You should definitely do it." If they are gonna have to stay on it forever?

I don't know I tell them I plan on taking it forever when people ask just like blood pressure or chloestrol drugs.

Regardless of what you say people (even your friends) are going to do whatever they want. I also know plenty of people that get some compounded from a wellness place, lose those 20 lbs. Then stop taking and gain it back. Weight Watchers has been milking this for 40+ years?

 

[joseblo]

So, I guess the reason for the question is, should I discourage friends that need to lose 20 or 30 lbs from taking Glp1s? Is it irresponsible to tell them "yeah, This stuff is great. You should definitely do it." If they are gonna have to stay on it forever?

To me it depends more on what %BW they need to lose to get to a healthy BMI/BRI, pre-existing conditions, and how old they are. I'm not on tirz for the weight as much as for the anti-inflammatory effects. I only lost ~40lbs, but it was a sizable fraction of my total weight. If you're 6'4" 230 and trying to get to 200, it's a lot easier to do than 5'2" going from 120-90lbs.

Also, if you're 21 years old you're not pre-diabetic or otherwise unwell, growth/sex hormones are running wild, I think it would be nuts to go on peptides. You're more likely to miss a hockey match because the body sculpting reta didn't agree with you, or your blood sugar crashed from the secretagague you're on, than you will score another goal. If you're 75 quit drinking, but still have fatty liver disease, then reta might give you an extra 10 years of life, even if you have to stay on it the whole time.

 

[randompersonrandom]

I started at 176 and hope to hit 125 in mid-March. I don't even intend to TRY to get off when I get to goal. Why should I? I've had MULTIPLE rounds of losing weight down to a certain point, and eventually gaining it all back and some. I'm 45, I have all the data in the world of what it's like to try not to be fat while not being on glp-1's, and my data says "I will almost certainly fail."

 

[DunningKruger]

It's funny. I just discussed this topic with my Botox nurse yesterday while in the clinic. I am one of those, always close to goal, yoyo-ing, sometimes 20 extra lbs folk. I eat a mostly clean carnivore diet, but I have always regained after Sema; never more than the original weight though.

I'm now losing with Reta and was discussing yesterday with the nurse, who uses Tirz. and recommended a maintenance dose when at goal. I'm of the opinion that I prefer to cycle any exogenous compound so that my system doesn't become reliant on it. Personally, I'll stop when goal is reached, and use an extra vial from the freezer when I see it pack back on.

 

[skeptick]

Just my opinion. I think that the majority of weight loss can be kept off provided that lifestyle changes were made. Keep eating healthy and exercising (whatever that means to you).

Of course the extra metabolic benefits will be lost so some weight gain would be natural to include inflammation weight.

These are just my thoughts, not a doctor, but did bang a nurse one time.

I married one, once upon a time. Everything had to be sterile, or it was filthy. Imagine, me a busted up old logger/biker... 5 kids later before I figured out which one I was.

 

[Dos-Dox]

I plan to titrate down when I hit goal weight every bit as slowly as I’ve been titrating up. I’m 6 months in and only up to 1.9 mg/week and am perfectly content with the 1-2 lb/week loss. (Folks will say the glucagon agonist effects don’t kick in until 4 mg but I don’t care. Weight is coming down and my blood markers have DRASTICALLY improved and I’m happy with the progress, so I’m doing what I want.)

My plan is to come off it completely and see what happens. If I gain weight back and it doesn’t stabilize at a “walking-around” weight I’m happy with, then I’ll use reta again to get back down to GW and then figure out what the lowest maintenance dose is that’ll keep me there. For me, I wouldn’t be happy if I didn’t at least try to titrate down to zero, so I have to know whether or not it’s possible for me.

This is my only GLP experience. I can certainly understand why those who have used them before, stopped, and regained them started them again and don’t intend to stop. But I have to know for myself if I can use it as a tool during this season of life and then move on without it.

If you’re looking for a body-builder type that uses a low dosage and cycles off and on, “Ayubace” on Instagram has a lot of reels discussing his philosophy with cycling.