Going from Tirzepatide to Reta

[Venne]

I would like to switch from Tirzepatide to Reta.
My goal is to avoid any further muscle loss and hopefully try to get back some of what I already lost on Tirz.

Any tips on how to calculating equivalent dose of Reta coming from 15mg (Zepbound) once a week?
Is there a chart somewhere? Some rule of thumb, or should I just start at min dose Reta and titrate back up?

Tips and advice of recommended stacks that work well with Reta.

 

[WholesomeApril]

Sorry to break it to you but Reta isn’t going to help you gain muscle back. You can do that without going thought the hassle of switching (switching from a large triz dose is a process)

Just cut your current dose of triz back so you can start hitting your protein intake and picking up heavy things

 

[Venne]

Sorry to break it to you but Reta isn’t going to help you gain muscle back. You can do that without going thought the hassle of switching (switching from a large triz dose is a process)

Just cut your current dose of triz back so you can start hitting your protein intake and picking up heavy things

To be honest, I am not well versed in the ways of lifting heavy things. Where to start? What should an appropriate protein intake be?

 

[eidos]

There is no dose equivalence between Reta and Tirz because they do not have the same affinities for GLP-1 and GIP receptors. And Reta is a glucagon receptor agonist, whereas Tirz is not. So they’re really not comparable, to the point that some people, including myself, use both in combination (type 2 diabetes).

Start with small doses of Reta (1 to ~2 mg) to see what side effects it causes in you. Then continue to increase the dose in 4-week increments until a steady state is reached, so you can assess the results against your goals.
The latest meta-analysis on sarcopenia, or muscle loss, published a few weeks ago, recommends 1.2 grams of net protein per kilogram of body weight per day. The weight in kilograms to use is your target weight, not your current weight. Most modern scales display muscle mass and skeletal muscle mass. Use that as your guide (it will also help you determine whether your weight goal is realistic and doesn’t put your health at risk).

There’s no need to think about tough weight-training sessions if that’s not your cup of tea.
Do a few minutes of controlled eccentric movements with weights each day. Take breaks during your work and spend 3-4 minutes doing eccentric movements, resistance band exercises, wall sits, or similar exercises.

I even did them on the subway or the bus, anywhere whenever I had some time to kill, using the bars (I come from a family of firefighters, not pole dancers ;-) and did a few wall sits instead of using a seat.

 

[lessthanhalf]

I am just going to second that swapping from tirz to reta to better preserve muscle is not really supported by the studies.

Things that do make a difference is any kind of resistance exercise, and higher protein intake, I would have said 1.5g/kg of body weight but the poster above suggests 1.2, either would be fine.

While losing muscle mass during weight loss is not ideal, in practical terms it is not an issue at all, unless you are starting from a point of already being very low on muscle mass, and most overweight and obese people carry extra muscle, partly from the anabolic state of overnutrition and partly the demands of moving a heavier body. So losing some muscle with the fat has been shown to substantially improve everyday physical performance, when weight is lost with GLP's. as less muscle is needed to move around a body that weighs less. While I was losing weight from 115kg to 75 kg it was totally obvious to me walking up a hill that every 10 kilos I lost made a huge difference to the amount of effort required to get up that hill, despite losing some muscle along the way.