Heart racing from Reta

[Adavis3053]

So everyone has heard of the great Reta which will officially be available in 2026 or 2027. I am very interested as it uses a 3 prong approach (sema is 1 and tirz 2) however i have read some mixed reviews. Some say it is a super appetite suppressor and others have reported it actually made them hungry! Also, i have heard the main side effect is increased heart rate. We all have side effects we can and cannot deal with. This is mine.

I have had nausea, diarreha and constipation with Sema. I can handle it. but heart racing scares me and i dont think i can handle that.

anyone have experiences positive or negative with REta?

 

[Morbius]

I started it recently so I am still on the baby dose of 2 mg.

I have still been losing 3 lbs/week and my appetite is suppressed strongly for a day or two after the shot, and moderately the rest of the week. Whatever label I put on that effect, it is enough to be helpful. I'm eating small meals and choosing to skip my second rich coffee drink or tasty beer, too.

Group consensus is that reta has the least appetite suppressant of the big three meds. If this is the least effective suppressant I cannot imagine what sema is like.

I have observed zero side effects other than a bit less regularity on the ol' throne. I'm adding fiber and miralax supplements to address that. No big deal.

I will stay on 2 mg until I feel like I need more.

AFAIK an uncomfortably high heart rate is a pretty rare side effect. An increase you can notice, but isn't bothersome -- like +10% -- seems to be somewhat common.

All you can do is give it a try. YMMV.

 

[Calm Logic]

Tirz + Survo can be a substitute for Reta, with less elevation of heart rate apparently.

 

[Galora]

AFAIK an uncomfortably high heart rate is a pretty rare side effect. An increase you can notice, but isn't bothersome -- like +10% -- seems to be somewhat common.

All you can do is give it a try. YMMV.

I guess the key it's what is your resting HR. Mine is 80-90 range. All glps increase hr but reta is the worst apparently. Tirz got my RHR to 110 today and I'm not having any fun. Can't even imagine what reta would do to me.

 

[m100568]

I guess the key it's what is your resting HR. Mine is 80-90 range. All glps increase hr but reta is the worst apparently. Tirz got my RHR to 110 today and I'm not having any fun. Can't even imagine what reta would do to me.

I guess everyone is different. When I started my RHR was 94. 8 1/2 months later and on 12mg Reta my RHR is 78. I've never experienced any racing. I know it is anecdotal, but these meds really do have a range of effects on different people. You don't know until you experiment on yourself.

 

[ktg123]

I stacked Tirz and Reta, I was on 9.5mg Tirz and 2.5mg Reta. My RHR used to be 70ish before any GLP-1s. A couple weeks ago it was up to 95. I stopped Reta 2 weeks ago to see what would happen. RHR is still over 90.

 

[Super Trips]

Tirz + Survo can be a substitute for Reta, with less elevation of heart rate apparently.

DEPENDS ON HOW MUCH YOU TAKE LOL

 

[EsSquared]

Heart racing isn't a 5-8 bpm increase.

I've read 2 ways to help mitigate that. Do long duration low intensity cardio regularly.
Instead of dosing every 7 days, dose every other day or even every day and just make sure you hit your weekly dose

 

[Galora]

I stacked Tirz and Reta, I was on 9.5mg Tirz and 2.5mg Reta. My RHR used to be 70ish before any GLP-1s. A couple weeks ago it was up to 95. I stopped Reta 2 weeks ago to see what would happen. RHR is still over 90.

Tirz (and all GLP-1s for that matter) increase RHR.
This increase might just be caused by Tirz. I was looking at my historical RHR, and I do have +20 or 30 bpms over my original pre-GLP numbers. I did have to stop my betablocker because my blood pressure went down, so that could also explain it a bit, but it's A LOT of increase with tirz alone.

 

[Ted R]

Tirz (and all GLP-1s for that matter) increase RHR.
This increase might just be caused by Tirz. I was looking at my historical RHR, and I do have +20 or 30 bpms over my original pre-GLP numbers. I did have to stop my betablocker because my blood pressure went down, so that could also explain it a bit, but it's A LOT of increase with tirz alone.

Not for everyone it doesn't. One size definitely doesn't fit all in this arena.
Reta spiked my rate to ~125 after only 2 hrs. after my first dose, and it took 4 weeks after stopping to return to my normal 68-70.
Started Tirz then at 2.5, have advanced to 7.5 every 5 days and and Surv2 3 days later and still normal HR.

 

[Caffeineo]

Recent article about this. Why Retatrutide increases heart rate

 

[Ted R]

Recent article about this. Why Retatrutide increases heart rate

Thanks for pointing that out. Very interesting read!

 

[hexagonal]

Recent article about this. Why Retatrutide increases heart rate

Curious if the supplements listed make an impact on RHR for anyone else. I've already been supplementing all of those at those dosages and they haven't done anything to lower my RHR lol

 

[Calm Logic]

I am ordering low-dose nebivolol from India just in case (5 mg tablets, which can be split in half). I read about it at the Meso forum for fellow users of the stimulant clenbuterol. Nebivolol could help I assume with elevated heart rate from reta, for when I try reta:

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Although nebivolol (5 mg) and the calcium antagonist nifedipine (20 mg) were equally effective in lowering blood pressure, nebivolol also significantly reduced heart rate (Van Nueten et al 1998a) and adverse events associated with nifedipine treatment caused a significantly higher number of patients to withdraw from the study compared with nebivolol-treated patients. Heart rate was also significantly reduced with nebivolol in a study comparing nebivolol (2.5–5 mg) with the calcium channel blocker amlodipine (5–10 mg) in elderly patients with mild to moderate hypertension (Mazza et al 2002). A high heart rate is linked to an increased risk of death in the elderly (Palatini et al 1999) and so an antihypertensive such as nebivolol that effectively lowers blood pressure and also lowers heart rate has dual benefits in this population.

But I don't have elevated heart rate from European (non-abusive) dosing of clenbutetol, so I assume I will be fine on reta too.

 

[kpake]

Heart racing isn't a 5-8 bpm increase.

I've read 2 ways to help mitigate that. Do long duration low intensity cardio regularly.
Instead of dosing every 7 days, dose every other day or even every day and just make sure you hit your weekly dose

Just wondering if this is solid advice? I feel like I've sourced multiple articles say to not dose more than 2x a week.

 

[EsSquared]

Eh, smaller doses generally = smaller side effects

However recent info from the trials reveal that there seems to be a coorelation between your current blood pressure and whether or not you will get a rise in heart rate from reta

Low blood pressure = more likely to get heart rate increase

 

[juGGaKNot]

Tirz + Survo can be a substitute for Reta, with less elevation of heart rate apparently.

what about tirz + maz ?

Low blood pressure = more likely to get heart rate increase

I have orthostatic hypotension and high HR since starting reta.

Could it be the Low blood pressure exacerbating the symptoms?

Thinking of getting mazdutide instead.

 

[Minkster]

I've been on Reta for 4mos and at 3mg for a month. My RHR was 58-62 before and now 62-66. When I first upped to 3mg I had several episodes where I felt weird almost shaky inside like you're about to have an anxiety attack. It was usually when I would get in bed at night but my hr wasn't really high. It wouldn't last long and seems to have stopped for now. Might come back with next dose increase??

 

[Adavis3053]

Any medications/remedies to stop the increased resting HR and other side effects. I want to try reta but am nervous

 

[trojanpeptide]

According to the trials, heart rate increases in a dose dependent manner. It peaks out at ~24 weeks and then starts to decline over the next 24 weeks. It remains slightly higher then the starting baseline, but not nearly as much as the peak.

 

[zpped]

Any medications/remedies to stop the increased resting HR and other side effects. I want to try reta but am nervous

All GLP1 have an increased RHR effect. Reta is only 1-2bpm more than Sema on average. There is no medical reason to be concerned as long as you're not tachycardic (rhr over 100bpm).

 

[woundcarping]

Any medications/remedies to stop the increased resting HR and other side effects. I want to try reta but am nervous

What specifically makes you nervous?

 

[Calm Logic]

The BP medication nebivolol (a beta blocker) can lower heart rate, but not sure about safety, interactions, etc:

Heart racing from Reta

So everyone has heard of the great Reta which will officially be available in 2026 or 2027. I am very interested as it uses a 3 prong approach (sema is 1 and tirz 2) however i have read some mixed reviews. Some say it is a super appetite suppressor and others have reported it actually made them...

glp1forum.com

If heart rate from reta becomes an issue and you are stuck with it for a while in your system, I'm sure a doc can prescribe something, if necessary. Just tell them the truth (or say you took compounded tirz, but the truth is usually the safest option medically).

As mentioned before, taurine, electrolytes, and hydration can be supportive. I got turned on to taurine at Meso, but most people make enough on their own. So not necessary usually. But some sides from GH peptides (like fluid retention) can stress the heart somewhat.

 

[Chrissven]

I had normal night while sleeping an HR of 54-63 since Reta, about 63-80 at night I already notice a difference. The body feels tense or restless.

 

[Adavis3053]

What specifically makes you nervous?

Mostly the side effects. I have heard it burns fat like crazy-not just supressing appetite......and i can handle slight nausea and bathroom issues.....but I don't play with the heart! the increase HR has me hesitant as does the restlessness and trouble sleeping but that could be fixed by some melatonin. mostly the HR

 

[Calm Logic]

The titration schedule with reta should help, as can splitting the dose to twice a week. Or just use tirz. I like tirz just as much (since I have sides with every GLP).

I know some people have HR issues with reta and discontinue due to insomnia (or, rarely, tachycardia), but I think it is overblown. It's not like clenbuterol (clen), which is a banned/unapproved heart stimulant (the opposite of a beta blocker). Even with clen, my heart rate was higher but nothing crazy.

 

[woundcarping]

Mostly the side effects. I have heard it burns fat like crazy-not just supressing appetite......and i can handle slight nausea and bathroom issues.....but I don't play with the heart! the increase HR has me hesitant as does the restlessness and trouble sleeping but that could be fixed by some melatonin. mostly the HR

Do you have a reason to think your heart can’t handle beating ~5 times more per minute at rest?

My heart beats considerably more beats exercising than the extra 5 per minute at rest.

 

[trojanpeptide]

My heart beats considerably more beats exercising than the extra 5 per minute at rest.

that is not the same thing at all.

Also, on heart rate, I watched a video yesterday about this.
Heart rate increases YT video.

 

[Peptidesearch]

I get increased HR - around 10bpm right after my shot for a few hours then it goes back to base line.

 

[woundcarping]

that is not the same thing at all.

Also, on heart rate, I watched a video yesterday about this.
Heart rate increases YT video.

Exercise is a stressor to the sympathetic system in varying degrees. GLP and GCGR peptides are some variety of a stressor to the sympathetic system. Caffeine is another sympathetic stressor that raises RHR.

An example of an extreme that came to mind is the increase in polyps/intestinal cancer in long distance runners, thought to be caused by blood flow repeatedly being directed away from digestion to support to “flight” endurance exercise causing repeated hypoxic injuries to the lining. A less extreme, shorter term example of the same is the diarrhea that can be caused by the same mechanics.


Regarding the link, it’s two guys sitting around saying heart rate goes up, HRV goes down… maybe it’s a risk, they don’t know.

"Again we don't have an enormous and overwhelming body of evidence on this you know we don't have that many patients in our practice and we frankly don't have that many that take it"

“I mean again, we’re really wildly speculating”

“Again our sample size is so small that I want to be very careful and note that you know everything I'm saying is you know again it could be nothing…”


My average resting heart rate decreased 7bpm after starting Tirz, peak to valley. Getting to therapeutic levels of Reta has increased my RHR to approximately the levels it was before starting Tirz. My RHR is still within the same +/- 5-7bpm averaged band it’s been in for the last 5 years.