Help! I need help with vial size etc.

[YoYoFat]

Maybe devil’s advocate here, but any other protocol doesn’t have as robust amount of evidence as Eli Lilly’s titration schedule. You’re talking about the SURMOUNT study with n=>5000 in a RCT vs some guy on an internet forum. Of course you don’t have to follow the schedule that Eli Lilly gives but the info and evidence is out there and it’s not a bad idea to follow it even if you’re going gray.

Yeah, no. Zero need to follow a profit driven titration schedule and unnecessarily increase dose at set doses that are designed entirely for the purpose of manufacturing at scale. The entire medical community will tell you to use the lowest dose of any med or peptide that’s effective. Zero, literally zero, need to increase until or unless it’s no longer effective.

 

[nevets]

Yeah, no. Zero need to follow a profit driven titration schedule and unnecessarily increase dose at set doses that are designed entirely for the purpose of manufacturing at scale. The entire medical community will tell you to use the lowest dose of any med or peptide that’s effective. Zero, literally zero, need to increase until or unless it’s no longer effective.

I think we both agree on the idea of not increasing dosages until someone stalls and they don't have any side effects. However, the earlier tirtration schedule wasn't necessarily accurate. The titration schedule only says 5mg, 10mg, or 15mg is maintenance. Also the price direct from manufacture is the same whether you get 2.5mg or 15mg, so it's actually technically cheaper with increased dosages.

Again, absolutely correct that there is no need to increase if it's effective, especially if going gray, because we are talking about individuals here, but the data does show that there is a dose-dependent increase with average weight loss on tirz with mean body weight change of 15% on 5mg, 19.5% on 10mg, and 20.9% on 15mg. SURMOUNT-1 also showed 30% of people losing over 20% of their initial weight on 5mg and 57% of people losing over 20% of their initial weight on 15mg. Data also showed that although there is a plateu with tirz, 10mg and 15mg showed a longer amount of time to reach the plateau when compared to 5mg.

In my opinion, if you are not under the medical supervision of a provider then it is a good idea to follow current evidence based practice when doing your own research with these research peptides, and the data is all out there and free!

SURMOUNT-1 PMID: 35658024

 

[cheaperseeker]

I think we both agree on the idea of not increasing dosages until someone stalls and they don't have any side effects. However, the earlier tirtration schedule wasn't necessarily accurate. The titration schedule only says 5mg, 10mg, or 15mg is maintenance. Also the price direct from manufacture is the same whether you get 2.5mg or 15mg, so it's actually technically cheaper with increased dosages.

Again, absolutely correct that there is no need to increase if it's effective, especially if going gray, because we are talking about individuals here, but the data does show that there is a dose-dependent increase with average weight loss on tirz with mean body weight change of 15% on 5mg, 19.5% on 10mg, and 20.9% on 15mg. SURMOUNT-1 also showed 30% of people losing over 20% of their initial weight on 5mg and 57% of people losing over 20% of their initial weight on 15mg. Data also showed that although there is a plateu with tirz, 10mg and 15mg showed a longer amount of time to reach the plateau when compared to 5mg.

In my opinion, if you are not under the medical supervision of a provider then it is a good idea to follow current evidence based practice when doing your own research with these research peptides, and the data is all out there and free!

SURMOUNT-1 PMID: 35658024

Of course, you are entitled to your opinion and you should do what feels right to you.

I will point out, though, that Eli Lilly funded this study, and studies are more likely to favor the preferred outcome of the sponsor.

 

[nevets]

Of course, you are entitled to your opinion and you should do what feels right to you.

I will point out, though, that Eli Lilly funded this study, and studies are more likely to favor the preferred outcome of the sponsor.

Sure, here’s a dose-dependent meta analysis that was not funded my Eli Lilly that analyzed biases in studies.
PMID: 38850440

 

[MsGizmo]

Sure, here’s a dose-dependent meta analysis that was not funded my Eli Lilly that analyzed biases in studies.
PMID: 38850440

I don't think anyone is actually arguing against upping the dosage when needed ... the argument being made is that you don't need to up the dosage as fast. The study attached to PMID: 38850440 as far as I can tell says nothing about the speed of people upping dosages over time and the effect on overall weight loss. I haven't even heard of anyone doing a study like that.

 

[Cassie MKM]

😅

🤣🤣The emoticons are so funny