Here to respect the research

[Cable7259]

Hi all,

Just getting around to my intro post. I've been on tirz for 18 months, down 40 lbs but kind of stalled and truly sick of the side effects. I also am tired of the 17000 hoops I have to jump through to keep my insurance covering it even though I know I'm one of the lucky few.

I'm 9 lbs from my stretch goal weight. I'm also interested in the Glow peptides, visceral fat targeting peptides, and NAD. I joined here to read about best practices, make sure I'm doing everything correctly and safely, and maybe even make a few friends along the way.

My mom and step-dad may be losing their coverage for tirz also and so I'll be doing research for them as well because they're definitely not internet savvy enough to follow the breadcrumbs.

I placed my first order for reta last night (from a non-grey vendor, I'm still learning the lingo, but a US-based peptide company, i.e. reseller) to see if I like it before moving to ordering grey.

Happy to be here! Thanks to all who came before and shared their knowledge. 🙂

 

[zanny-kanny]

Hello! Been off forum for a bit, so I'm late to welcome you.

Just to let you know, ordering peptides for research when you're not a researcher is called 'going grey'. It's not black market because it isn't illegal illegal yet, but it isn't quite legal either, hence the term 'gray'.

It sounds like insurance companies have already started ditching folks who need GLP1 assistance to lose weight. Sorry to hear it happened to you. Hopefully your family won't lose their coverage but it's going to happen more and more. It's good to get ahead of it and help them continue their journey.

As for visceral targeting peptides you need to research tesamorelin. It was developed specifically to eliminate this type of fat (its brand name is Egrifta). It specifically targets visceral in HIV patients, but visceral is visceral no matter who carries it around. I lost a bunch of weight with reta but not the visceral so I added tesa 2 months ago (in addition to the reta) and have lost 22 lbs. It doesn't target subcutaneous fat just visceral, so it is your go-to for this type of fat loss. My dosage protocol is 1.5mg tesa nightly fasting, no days off.

Good luck on your journey!

 

[Cenn_Buie]

Hello! Been off forum for a bit, so I'm late to welcome you.

Just to let you know, ordering peptides for research when you're not a researcher is called 'going grey'. It's not black market because it isn't illegal illegal yet, but it isn't quite legal either, hence the term 'gray'.

It sounds like insurance companies have already started ditching folks who need GLP1 assistance to lose weight. Sorry to hear it happened to you. Hopefully your family won't lose their coverage but it's going to happen more and more. It's good to get ahead of it and help them continue their journey.

As for visceral targeting peptides you need to research tesamorelin. It was developed specifically to eliminate this type of fat (its brand name is Egrifta). It specifically targets visceral in HIV patients, but visceral is visceral no matter who carries it around. I lost a bunch of weight with reta but not the visceral so I added tesa 2 months ago (in addition to the reta) and have lost 22 lbs. It doesn't target subcutaneous fat just visceral, so it is your go-to for this type of fat loss. My dosage protocol is 1.5mg tesa nightly fasting, no days off.

Good luck on your journey!

Interesting to read that reta didn't get rid of your visceral fat. That is supposed to be one of the key benefits. How are you measuring how much visceral fat you have lost?

 

[NoMoreFatPants]

Hi all,

Just getting around to my intro post. I've been on tirz for 18 months, down 40 lbs but kind of stalled and truly sick of the side effects. I also am tired of the 17000 hoops I have to jump through to keep my insurance covering it even though I know I'm one of the lucky few.

I'm 9 lbs from my stretch goal weight. I'm also interested in the Glow peptides, visceral fat targeting peptides, and NAD. I joined here to read about best practices, make sure I'm doing everything correctly and safely, and maybe even make a few friends along the way.

My mom and step-dad may be losing their coverage for tirz also and so I'll be doing research for them as well because they're definitely not internet savvy enough to follow the breadcrumbs.

I placed my first order for reta last night (from a non-grey vendor, I'm still learning the lingo, but a US-based peptide company, i.e. reseller) to see if I like it before moving to ordering grey.

Happy to be here! Thanks to all who came before and shared their knowledge. 🙂

Welcome! I an new to the forum as well. Been on GLP1 for 10 months and lost 30-35 lbs depending on the day. I am researching peptides and have been interested in the tesamorelin. The biggest thing holding me back is the amount I would have to use every month and the corresponding price of it. I am currently researching small amounts of reta and cagrilintide from a US based company to see if I felt it was worth the investment for me. I plan to expand my search and see if I can find better pricing.

 

[Calm Logic]

Regarding pricing, 67 cents per mg is a good price for reta. For tirz, 34 cents. Not familiar with cagri pricing.

 

[NoMoreFatPants]

Regarding pricing, 67 cents per mg is a good price for reta. For tirz, 34 cents. Not familiar with cagri pricing.

After weeks of researching, I am close to making my first order. I am trying to figure out crypto right now. Got a fancy wallet to transfer into and such. Then I got distracted by posts about tariffs just now. This forum is a wealth of information.

 

[zanny-kanny]

Be careful with cagri. Indications are that it is not safe in its current formulation.
Cagrilintide and amyloid fibrils

 

[Calm Logic]

It makes sense to use it up sooner than later, if degradation is an issue:

I also checked the ph and it was about 5-6 which explains why you did a mix, but the issue is that ph is a 'thing' throughout the manufacturing process not just at end stage so mixing down doesn't (to my understanding) 'cure' poor manufacturing process. My approach instead is to use a vial for WAY less than 4 weeks, I generally discard after 3 weeks to potentially limit degradation but I might be in the land of perception here. Overall I take some comfort that they apparently tested 27 variants of amylin agents and settled on cagrilintide for the very reason of stability.

Regarding fibrils:

Research Grade Cagrilintide !

Sharing for further discussion and research. Has anyone here experienced the symptoms described in the article? https://onthepen.substack.com/p/its-not-just-powder-and-water-the

glp1forum.com

Fibril stories are based on old studies derived from pramlintide. Cagri is a modified version (read N14E and V17R mutations, etc) to mitigate that concern and, other improvements (C-20) to provide a long-acting version so you pin only once a week. I am not a medical professional, but I read studies, not postings from bloggers trying to get traffic. Kicking a dead horse.

 

[MsGizmo]

I placed my first order for reta last night (from a non-grey vendor, I'm still learning the lingo, but a US-based peptide company, i.e. reseller) to see if I like it before moving to ordering grey.

Someone correct me if I'm wrong .. but I'm pretty sure there are no non-grey venders of reta.

 

[zanny-kanny]

Reta is not released yet. Probably will be in 2026. So all reta is research grade and thus grey when purchased for non research purposes.

 

[zanny-kanny]

It makes sense to use it up sooner than later, if degradation is an issue:



Regarding fibrils:

Research Grade Cagrilintide !

Sharing for further discussion and research. Has anyone here experienced the symptoms described in the article? https://onthepen.substack.com/p/its-not-just-powder-and-water-the

glp1forum.com

I've read all the discussions here about the safety of cagri. The fact that Novo Nordisk
separates it in their dual chamber CagriSema preparation to preserve the 4.0 ph speaks volumes. Better to be safe than sorry.

 

[Calm Logic]

I don't plan to use cagri at all. I had enough fatigue from higher doses of tirz.

 

[zanny-kanny]

I injected one dose before I read the articles regarding amyloid fibril formation and ditched the rest. Too bad, it really worked on lowering blood glucose levels. Once they perfect their formula it will indeed be a worthy peptide for use with insulin resistance.

 

[Calm Logic]

The addition of cagri didn't seem to help blood sugar for @nonyabizznez:

I used Cagri with both and I find it effective extending my suppression on days 5/6. Cagri seemingly has no effect on my glucose.

Similarly:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01163-7/abstract

The mean change in HbA1c with CagriSema was greater versus cagrilintide, but not versus semaglutide.

 

[zanny-kanny]

I wore a Stelo (an over the counter continuous blood glucose monitor) when I pinned it and my blood glucose level dropped almost immediately and was long lasting. It did better than Reta on keeping my blood glucose level, which was surprising to me. I think Tesa counteracts Reta too much (Tesa increases blood sugar level more than Reta can lower it).

 

[Calm Logic]

Any fatigue?

 

[zanny-kanny]

Yes. I was already fatigued from taking the Reta and the Tesa (an increase to 2mg Tesa brought on insomnia, so I decreased back to 1.5mg, which is less sleep disruptive in me), but I noticed even greater fatigue when I pinned the cagri. I was hoping to replace reta with cagri (for blood sugar control), not to use them together, so I was disappointed with this result.

 

[MoonWillow]

As for visceral targeting peptides you need to research tesamorelin. It was developed specifically to eliminate this type of fat (its brand name is Egrifta). It specifically targets visceral in HIV patients, but visceral is visceral no matter who carries it around. I lost a bunch of weight with reta but not the visceral so I added tesa 2 months ago (in addition to the reta) and have lost 22 lbs. It doesn't target subcutaneous fat just visceral, so it is your go-to for this type of fat loss. My dosage protocol is 1.5mg tesa nightly fasting, no days off.

I have tesa ready to go but I am hesitating because of the water retention possibility. Any advice there?

Hi all,

Just getting around to my intro post. I've been on tirz for 18 months, down 40 lbs but kind of stalled and truly sick of the side effects. I also am tired of the 17000 hoops I have to jump through to keep my insurance covering it even though I know I'm one of the lucky few.

Welcome to the community!!!

 

[zanny-kanny]

I have tesa ready to go but I am hesitating because of the water retention possibility. Any advice there?

Welcome to the community!!!

I believe it does but it's not a huge problem if you watch your salt consumption. There is a lot of salt hidden in many prepared products so you have to be vigilant.

I use my wedding ring as a surefire indicator of when I'm retaining water and most days I do not have a problem, it is only when I eat something with a good deal of salt, like bacon, ham or chicken tenders.

 

[MoonWillow]

I believe it does but it's not a huge problem if you watch your salt consumption. There is a lot of salt hidden in many prepared products so you have to be vigilant.

I use my wedding ring as a surefire indicator of when I'm retaining water and most days I do not have a problem, it is only when I eat something with a good deal of salt, like bacon, ham or chicken tenders.

Thank you!!

 

[nonyabizznez]

I've read all the discussions here about the safety of cagri. The fact that Novo Nordisk
separates it in their dual chamber CagriSema preparation to preserve the 4.0 ph speaks volumes. Better to be safe than sorry.

Same dude:

Novo Nordisk Eyes Manufacturing Edge with Single-Chamber CagriSema in New Phase 1 Trial

Novo Nordisk is taking its combination obesity treatment CagriSema into uncharted territory, kicking off a Phase 1 trial that could significantly shift the trajectory of its manufacturing strategy. The trial, quietly launched on December 2, explores a single-chamber formulation of CagriSema, a...

www.onthepen.com

I don't want to get into the fibrils and oligomers debate. All unapproved peptides are a personal choice and can be our generation's asbestos.

I've been taking Cagri for 10 months for possibly extended suppression on my 5mg Tirz that got me beyond goal. It's good to know that you get immediate glucose control although it having no impact on mine pretty much demonstrates why it'll most likely never be released as a stand alone drug.

It would be interesting to know how long the Cagri helped control your glucose (?) Although the reason for 7 day dosing schedules with Sema and Tirz is another can of worms it can be argued 7 days is the duration of dependable glucose control. At least that's what my glucose readings indicate (92 avg afternoon fasting glucose tapers up a bit day 6).

 

[FlowerFairy]

Yes. I was already fatigued from taking the Reta and the Tesa (an increase to 2mg Tesa brought on insomnia, so I decreased back to 1.5mg, which is less sleep disruptive in me), but I noticed even greater fatigue when I pinned the cagri. I was hoping to replace reta with cagri (for blood sugar control), not to use them together, so I was disappointed with this result.

Huh. One of the biggest reasons I switched to Reta was the crushing Tirz fatigue. I’ve been much less fatigued on Reta only.