Higher dose for higher weight

cloratheshadow

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Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.
 
Keep it simple, increase your Tirz.

Tirz primarily works by reducing consumption with less hunger and food noise. You’ve got plenty of runway left.
I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!
 
I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.
 
I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.
Im definitely very dialed in with nutrition. Lowish carb, Whole Foods, no liquid calories, around 1700 cals a day (2300 is maintainance) tons of lean protein. I am still losing a tiny amount but it’s been really hard to maintain a calorie deficit. I feel like the Tirz wears off completely after a couple days and I’m back to tons of food noise and hunger.
 
I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!

I’ve not heard any credible accounts of people blowing out receptors, including people taking 20+mg/week, some stacking with Sema for more GLP exposure.

I started split dosing my third week on Tirz, moved to Reta and kept splitting. Food noise returning on day 4-5 was my initial reason for splitting.
 
Man I hear you big boy. I'm hungry as fuck too. Don't forget that you can always take more. You just can't always take less.

It took 2 weeks for the appetite suppression to start working properly for me. I started at 0.5mg reta and kept blasting until I hit 2mg for the week, then I dosed 1mg every 3 days. Now I'm up to 2mg every 3 days and considering stacking cagri or tirz as well.

Make sure you aren't dosing once a week. Split your dose in half and dose every three days. Alternate the reta with the tirz. Give it some time to work, but don't be afraid to blast some more if you need the appetite suppression. I sometimes do a little 0.5-1mg touchup between doses.
 
Since your diet is good, sounds like it may be time to bump and/or split. The argument against splitting is that you may be more likely to build up a tolerance if the levels in your system are more constant vs the up and down of a weekly dose. Its theoretical, but it also makes sense. Personally, I would be in the bump the dose slightly camp over the split camp, but both are valid options.
 
Man I hear you big boy. I'm hungry as fuck too. Don't forget that you can always take more. You just can't always take less.

It took 2 weeks for the appetite suppression to start working properly for me. I started at 0.5mg reta and kept blasting until I hit 2mg for the week, then I dosed 1mg every 3 days. Now I'm up to 2mg every 3 days and considering stacking cagri or tirz as well.

Make sure you aren't dosing once a week. Split your dose in half and dose every three days. Alternate the reta with the tirz. Give it some time to work, but don't be afraid to blast some more if you need the appetite suppression. I sometimes do a little 0.5-1mg touchup between doses.
I’m a big lady excuse me.. 🤣🤣🤣🤣
 
Since your diet is good, sounds like it may be time to bump and/or split. The argument against splitting is that you may be more likely to build up a tolerance if the levels in your system are more constant vs the up and down of a weekly dose. Its theoretical, but it also makes sense. Personally, I would be in the bump the dose slightly camp over the split camp, but both are valid options.
I was splitting it but noticed better suppression every 5/6 days instead of 3! But adding a touch of Reta hopefully will help more
 
Make sure you aren't dosing once a week. Split your dose in half and dose every three days.
I was listening to a podcast with a doctor the other day, where he said it's much better to dose once a week, cause we give time for the body to flush some of the peptide out and resensitize the receptors, which results in being able to use the peptide for a longer time on lower doses more effectively. Can't remember which doc that was, though it sounds interesting and kind of logical to me. Have you noticed any difference going once a week vs. every 3-4 days?
 
Big un is hilarious 🤣🤣🤣 I can’t help it I’m like a dog — food motivated
Food noise was my thing, rarely hungry, always down to eat.


My goal will have me losing ~33-35% of my starting weight on GLP or ~38-40% of my ATH weight back in 2018.

With 12mg/weekly of Reta, only 24% lost 35% or more. My dose is currently 16mg/week to tip the scales in my favor.

1777139303320.webp
 
I was listening to a podcast with a doctor the other day, where he said it's much better to dose once a week, cause we give time for the body to flush some of the peptide out and resensitize the receptors, which results in being able to use the peptide for a longer time on lower doses more effectively.
I've heard the same bit of wisdom passed around. I can't say if it's true or not, though it doesn't sound right to me.

I can't compare the two because I've never gone more than 5 days without a dose. The hunger is too much lol. I absolutely love eating. Hell the other day I dosed my 2mg early trying to get out of eating some brownies I made for my dad. Next day I was sick as a dog from having so much GLP in my system and I still ate a brownie the size of my head. Then pigged out after bed too.

I think I need cagri LOL
 
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I just get nervous because I hear about blowing out your receptors and people not feeling it anymore but honestly I already don’t so…my body definitely is telling me to increase. I am still losing a tiny amount but that’s from exercise and really struggling to eat in a calorie deficit. I will increase and hopefully that helps!
GLP1s and potential sensor desensitization is a misconception, at tested dosages. They've been proven to not to have that issue because they work systemically and don't focus on any single set of receptors, like many peptides do. So feel free to titrate up slowly until you feel like it's working.
 
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I was listening to a podcast with a doctor the other day
GLP1s and potential sensor desensitization is a misconception, at tested dosages.
Seems like every piece of information that comes from a podcast, content creator, or blog is false. Everybody is cashing in on the GLP craze trying to get clicks. Everybody has an affiliate link. I'd bet money that doctor on that podcast is selling peptides and wellness supplements.

The other day, my stepmom shared a video of someone talking about Reta and he was fabricating studies for his content. Literally, she commented for more information, and he sent her a PDF of a fake study with fabricated results claiming benefits to taking 0.25mg of reta for anti aging. Littered throughout were, you guessed it, affiliate links.

Don't trust anything that doesn't come from some random guy on this forum speaking with absolute confidence.
 
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I’ve not heard any credible accounts of people blowing out receptors, including people taking 20+mg/week, some stacking with Sema for more GLP exposure.

I started split dosing my third week on Tirz, moved to Reta and kept splitting. Food noise returning on day 4-5 was my initial reason for splitting.
yeah, I think that is instragram influencers conflating running cycles of reta and testosterone. I see "influencers" talking about desensitizing sensors and cycling, those people already have low body fat and are trying to get shredded. Most of us are trying to get a healthy body weight and the studies are based on longer timeframes
not cycling.
 
Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.
You may not be getting the glucagon agonism intensity at that low of a dose of reta. I am at 8 mgs but am considering some added triz or sema for hunger. Reta doesnt seem to curb my hunger that well but im still slowly losing fat. Maybe look into flip flopping your triz and reta stack.
 
You may not be getting the glucagon agonism intensity at that low of a dose of reta. I am at 8 mgs but am considering some added triz or sema for hunger. Reta doesnt seem to curb my hunger that well but im still slowly losing fat. Maybe look into flip flopping your triz and reta stack.

GCGR is dose dependent, as best I can tell. My theory is/was/has been to titrate Reta as quickly as sides allow, otherwise it might as well be taking Tirz if not for the GCGR... this is assuming the goal is losing the big'n status.
 
GCGR is dose dependent, as best I can tell. My theory is/was/has been to titrate Reta as quickly as sides allow, otherwise it might as well be taking Tirz if not for the GCGR... this is assuming the goal is losing the big'n status.
100% agree, thats my thought process as well. I am obviously no dr, just some random internet poster but I feel like the poster is probably just wasting/getting no effect from the reta.
 
Im definitely very dialed in with nutrition. Lowish carb, Whole Foods, no liquid calories, around 1700 cals a day (2300 is maintainance) tons of lean protein. I am still losing a tiny amount but it’s been really hard to maintain a calorie deficit. I feel like the Tirz wears off completely after a couple days and I’m back to tons of food noise and hunger.
I don't know enough about you to really advise.
But I will say, 1700 cals a day would definitely be too high for me to lose any significant amount per week, regardless of quality of food. I've been shooting for 1200 cals a day and high protein content and haven't hit a stall yet. I'll freely admit though, the food noise is almost none existent for me on 5mg Tirz. so there are some days I don't hit my target of 1200 calories.
I recently added 1mg of Reta mid week as my goal is to up Reta for maintenance, and drop Tirz to a microdose.
65lbs lost, 61 yr old female, Tirz since Dec 1st.
 
I don't know enough about you to really advise.
But I will say, 1700 cals a day would definitely be too high for me to lose any significant amount per week, regardless of quality of food. I've been shooting for 1200 cals a day and high protein content and haven't hit a stall yet. I'll freely admit though, the food noise is almost none existent for me on 5mg Tirz. so there are some days I don't hit my target of 1200 calories.
I recently added 1mg of Reta mid week as my goal is to up Reta for maintenance, and drop Tirz to a microdose.
65lbs lost, 61 yr old female, Tirz since Dec 1st.
I weigh 260 so 1200 is extremely low for me. I do not want to lose muscle if I can help it. If I ate 1200 a day that would be over 1000 calorie deficit for me 🙁 but congrats on that weight loss dude!!
 
Been stalled at least 2-3 weeks with decent hunger. I’ve titrated up slowly faster than recommended but I’ve read the more you have to lose more likely the higher dose you need. I have another 75 lbs to lose after losing 60 naturally and 20 with Tirz. I’m also stacking a bit of Reta. So 5mg Tirz 1 mg Reta. Would it be stupid to continue titrating? I’m only on week 7 but I just don’t feel it like I did the first month.
Week 7 is still early in the journey. I had to remember that Glp-1s aren’t magic pills but more like aids to support lifestyle changes. After going to 7.5 at week 9 I experienced more weight loss.
 
Given you are trying to lose 60+75 lbs , you are almost certainly going to need to eventually up the doses to standard maximum doses of 15mg tirz or what ever the equivalent is if mixing it with reta, or even possibly higher if that does not get you to your goal, it does not mean you need to rush to get there. The main reason to not increase doses is side effects, I have not seen you say you are getting any. And the fact that you are hungry is a strong indicator that the dose you are on is not causing a lot of gastrointestinal side effects and you can increase doses with low risks of side effects. Trying to achieve massive weight loss on low doses is not realistic in most cases.
The only other thing you need to consider is that you have already lost 60 lbs, this does make a lot of difference to how you might respond to the medication , and to energy expenditure . That degree of weight loss will be enough to reduce energy expenditure a fair bit, and increase hunger ,so you current doses may just be enough to keep you at a new lower weight but not enough to keep losing weight. Would really need to know age , height , activity levels and how long you have been losing weight for to make any guesses as to how much of an effect this might have. But if the calculations on your current calorie deficit were based on your start weight , you might find they are no longer accurate. I know my energy expenditure dropped by half from 145kg to 75kg, and weight loss dropped from 6kg per month to 0 kg per month on exactly the same calorie input.
 
Seems like every piece of information that comes from a podcast, content creator, or blog is false. Everybody is cashing in on the GLP craze trying to get clicks. Everybody has an affiliate link. I'd bet money that doctor on that podcast is selling peptides and wellness supplements.
I know, I know. 🙂 The only thing I trust is hard scientific evidence 🙂 Need to do more research on this. I do realize that horse-sense is often far from reality, but I thought it was interesting and wanted to compare it to the actual experiences of ppl here.
 
I know, I know. 🙂 The only thing I trust is hard scientific evidence 🙂
I trust that least of all. Hard scientific evidence sent me to the hospital for a week after I got that second pfizer shot. No sir I will stick to circumstantial anecdote based evidence from overconfident forum goers.
 
I think the 5:1 Tirz:Reta ratio is probably pretty sound overall. A stall for a couple weeks is going to happen so I wouldn't suggest moving based on that. You are on a low dose, so bumping it is reasonable, but I wouldn ask first, is your diet dialed in? Are you getting a good amount of protien and enough calories? Ideally, 1g per lb of protien and around a 500-700 tops deficit. If you are hungry and you are not doing this, or you don't know if you are doing this, its probably a diet issue, not a med issue. If you can fix the issue with a diet adjustment, that is always the better option, if not, I would say bump it.
Sleep too. Sufficient sleep matters.
 

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