How much Mots-c is anyone who is on it taking? And, how frequently are you injecting?

JoonyO said:
5mg MWF morning. Second week. I get a LITTLE itchiness (10-15 minutes?) and slightly red ISR. Nothing that really bothers me much. I can't say it's been detrimental to my 2 hour cardio morning sessions every day.
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wow 2 hours, that is impressive. To me at least!
 
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randompersonrandom said:
I'm trying to wait two full weeks before I call it in a for-certain way, because I'm trying to wait out possible placebo effect, but I feel BETTER. Not as awake as I felt before I started Tirzepatide (end of July), but MUCH more awake than I have been lately. I do it right before work, so I'm awake through the workday, and have been working out again.
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That great news.
 
desinr-gal said:
That great news.
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yes--I'm really happy so far. I have high hopes for the MOTS-C, because I'm pretty bored of having ANY fatigue. I'd tolerate it for the rest of my life if it came to that, I can breathe when I'm sleeping again, I look and feel hot, and I'm out of my mind with happiness; if that comes with being tired, so be it. But I sure would like a magic shot to cure that.
 
I’m on the mots-c part of the S-31, mots-c, NAD+ protocol. I have 40mg (4ml saline) in a nasal spray bottle and do two shots up each nostril before I go running every morning. I had the nasal from a previous research study. It seemed to work well and I fully confident that I wouldn’t have a reaction to the injection, so I just kept making more spray and it seems to work as I feel effects. My A1c has fallen significantly and I am able to run a little faster than normal. I am going to have my fasting insulin and fasting glucose levels tested after I finish the protocol, in order to calculate my HOMA-IR (Homeostatic Model Assessment for Insulin Resistance).
 
I had been looking into doing the NAD+/SS-31/MOTS-C protocol, and have been reading other threads about it, but no one in those threads has mentioned anything about taking Betaine with their NAD+. Not sure if I am allowed to mention a specific website in here, but this is a quote from that site warning about depleting the "methyl pool", and needing to take betaine to prevent serious problems resulting from that depletion: 1777196539875.webp
 
Stayinalive said:
I had been looking into doing the NAD+/SS-31/MOTS-C protocol, and have been reading other threads about it, but no one in those threads has mentioned anything about taking Betaine with their NAD+. Not sure if I am allowed to mention a specific website in here, but this is a quote from that site warning about depleting the "methyl pool", and needing to take betaine to prevent serious problems resulting from that depletion: View attachment 21212
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Nice find. Can't wait to drop the word Homocysteine in a conversation with a NAD+ worshipper.
 
Anecdotally, I’ve seen some tidbits here and there espousing the pairing of NAD+ with glutathione - glutathione being a very strong antioxidant.
 
Wife and I love mots as part of our morning/ preworkout stack. We decided to run it in conjunction with our workout plan 4 on / 1 off. I am on 3mg and she is on 2mg for that dosing protocol
 
Stayinalive said:
I had been looking into doing the NAD+/SS-31/MOTS-C protocol, and have been reading other threads about it, but no one in those threads has mentioned anything about taking Betaine with their NAD+. Not sure if I am allowed to mention a specific website in here, but this is a quote from that site warning about depleting the "methyl pool", and needing to take betaine to prevent serious problems resulting from that depletion: View attachment 21212
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I thought it was common knowledge you need to stack TMG (Trimethylglycine/Betaine Anhydrous) or another Methyl donor with NAD. Sounds like it may not be, so keep spreading the word.
 
FNG33 said:
I thought it was common knowledge you need to stack TMG (Trimethylglycine/Betaine Anhydrous) or another Methyl donor with NAD. Sounds like it may not be, so keep spreading the word.
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It's not mentioned in the protocol, and I downloaded the original document. Seems like that would be an important thing to mention, since it can lead to heart issues.
 
chewonmysac said:
Nice find. Can't wait to drop the word Homocysteine in a conversation with a NAD+ worshipper.
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I think it may be slightly more important to mention the heart issues and the betaine. And FNG33 brought up Trimethylglycine/Betaine Anhydrous, so now I need to look into what that's all about. Going to try posting the link to the article, hopefully it won't get me in trouble. https://jaycampbell.com/anti-aging/nad-the-most-hyped-up-anti-aging-compound-of-2022/ Apologies if this link isn't allowed, but the information seems important.
 

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FNG33 said:
I thought it was common knowledge you need to stack TMG (Trimethylglycine/Betaine Anhydrous) or another Methyl donor with NAD. Sounds like it may not be, so keep spreading the word.
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Is betaine the same thing as trimethylglycine?
 
Stayinalive said:
I had been looking into doing the NAD+/SS-31/MOTS-C protocol, and have been reading other threads about it, but no one in those threads has mentioned anything about taking Betaine with their NAD+. Not sure if I am allowed to mention a specific website in here, but this is a quote from that site warning about depleting the "methyl pool", and needing to take betaine to prevent serious problems resulting from that depletion: View attachment 21212
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I'm glad I saw this! I'll be starting nad+ as soon as it comes in and I had never heard of this. You will be sending me down the research rabbit hole!
 
Alex Kikel goes deep here. Starting does are smaller (300mcg.)
View: https://www.youtube.com/watch?v=zFzp_jGfISI

Tons of various protocols.
I'm tinkering here.
My mito health was good based on markers avail in my blood work.
I'm 2mg. Felt like superman at work one day. Clean energy. Nothing others.
I have the materials to run SS31, NAD, Mots-c protocol.

Seems SLU-PP-332 plays a role in the Mito package.
 
Mr. Blonde said:
To preface, I never did ss31. I was blasting 10mg of mots c 3x per week. Did this for 4-6 weeks. I didn't really feel anything enough for me to do another cycle.

Maybe the ss31 beforehand does make a huge difference like they say.
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What benefits did you see from Mots c?
 
Unfortunately for me they were very negligible. Guess I'm already optimized! Haha, jk.

But your experience could be better than mine. Good luck!
 
Rickcaps said:
What benefits did you see from Mots c?
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Most people see an increase in clean energy not the short jittery effect of pre workout.

The benefits of MOTS-c include:
 
Stayinalive said:
I had been looking into doing the NAD+/SS-31/MOTS-C protocol, and have been reading other threads about it, but no one in those threads has mentioned anything about taking Betaine with their NAD+. Not sure if I am allowed to mention a specific website in here, but this is a quote from that site warning about depleting the "methyl pool", and needing to take betaine to prevent serious problems resulting from that depletion: View attachment 21212
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I agree it's good to take a methyl donor supplement when dosing NAD+ however I'd be wary of the above explanation. I don't think the details of how exactly NAD+ metabolism works have been understood by science at this point.
 
1 mg an hour before my workout. Roughly 4-5x per week
 
Has anyone found something that can alleviate the bloating and GI discomfort from taking Betaine Anhydrous or Trimethylglycine (TMG). I took a single dose yesterday, and my gut still feels distended and bloated. Doesn't seem to be gas related.
 
tendency said:
I agree it's good to take a methyl donor supplement when dosing NAD+ however I'd be wary of the above explanation. I don't think the details of how exactly NAD+ metabolism works have been understood by science at this point.
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So if you have started taking the NAD+, and ur adding TMG, hopefully, you are not also taking any other methylators. I take Methylene blue, but not at any serious dose, I take a half a drop a day, but it is a methylator. So they say, too much of a good thing... well, this is no exception. If ur taking Methylene Blue, then u may need to cut back on your TMG. I don't know how much, but some. And u may want to check some of your other supplements, some B vitamins are methylated, I take a methylated B-12. Just thought I'd let u know, could be important.
 
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