How soon did you start feeling effects after first dose?

lil ghost

lil ghost

GLP-1 Apprentice
Member Since
Mar 24, 2026
Posts
37
Likes Received
106
Location
Midwest
idk if it's a placebo effect or if I'm just a quick responder, but I'm already feeling a complete lack of appetite less than 24 hours after my first pin of tirz. I even started on a low dose (2mg) since I'm on the lower end of the "healthy" BMI range. I could be deluding myself into thinking that I'm not hungry, but it legitimately feels like I'm full despite not eating much today.

This is the very first time I've tried any kind of peptide, so I don't have any personal reference points to compare with my current experience. I'm just curious if anyone else has felt effects kick in right away or if I'm delusional and/or an anomaly.
 
I reacted rather quick to Reta, considering I was in a bad mindset before my first injection thinking nothing would work, next day I was locked in, eating healthy, keeping to the same diet I am currently with no temptations for sugar, my dad on the other hand took 2-3 weeks for the food noise to disappear, strange how we all act so different even from the same vial
 
My being able to tell starts approximately 24 hrs after a dose and peaks by 48 hrs after a dose.
 
I feel it very fast. Within an hour or two. It will be more intense if you do it in your stomach. You should really feel it the next day 🙂 but once it starts building you’ll feel it all the time even when you need to dose usually
 
With tirz, I can set a clock to the explosive diarrhea and projectile vomiting at the 36 hour mark after a first dose after a break, or upping my dose. but i do start feeling the suppression by the time i wake up (i take my shot right before bed)
 
I keep seeing posts from people starting GLP's on low doses who are not very overweight, who seem to get quick or significant responses on low doses. It make me wonder if it is more likely to do this in those who are less overweight, than those who have more weight to lose and presumably more severe metabolic and hormonal abnormalities - more insulin and leptin resistance etc. After losing 70kg and having side effects from low dose ozempic , I managed to crank the dose of tirzepatide to 15mg over a month and was still a bit hungry. ( using small frequent doses to reduce risks of catastrophic side effects )
 
lessthanhalf said:
I keep seeing posts from people starting GLP's on low doses who are not very overweight, who seem to get quick or significant responses on low doses. It make me wonder if it is more likely to do this in those who are less overweight, than those who have more weight to lose and presumably more severe metabolic and hormonal abnormalities - more insulin and leptin resistance etc. After losing 70kg and having side effects from low dose ozempic , I managed to crank the dose of tirzepatide to 15mg over a month and was still a bit hungry. ( using small frequent doses to reduce risks of catastrophic side effects )
Click to expand...
Thanks for sharing LTH. I’ve been disappointed I wasn’t getting the same wondrous Miracle Drug Experience ™. I’m early in the schedule, but I haven’t felt shit. Same appetite and everything
 
day after, i felt like every piece of food was descending in a huge lump LMFAO. i felt fuller quicker. i didn’t care about food as much. it was great!!! i have crazy food noise normally
 
I felt it the next day. I was on lunch break at work. I could only eat half of my lunch because I was full. I do remember being a little weirdly disappointed, somewhat confused, too. I have been over eating all these years and figured that maybe this how normal people eat. I'm used to small meals now after 3.5 months. Sometimes I have to force some meals to get my protein in for that day. Don't be in a rush to increase dosage...my opinion.
 
When I started Ozempic about a year after losing about 70kg, that was the first thing I noticed, feeling too full to finish eating a fairly small amount of food, not sure I had ever actually experienced that before then.
 
lil ghost said:
idk if it's a placebo effect or if I'm just a quick responder, but I'm already feeling a complete lack of appetite less than 24 hours after my first pin of tirz. I even started on a low dose (2mg) since I'm on the lower end of the "healthy" BMI range. I could be deluding myself into thinking that I'm not hungry, but it legitimately feels like I'm full despite not eating much today.

This is the very first time I've tried any kind of peptide, so I don't have any personal reference points to compare with my current experience. I'm just curious if anyone else has felt effects kick in right away or if I'm delusional and/or an anomaly.
Click to expand...
Pinned my first 2mg dose of R. At first…nothing. Thought it might be bunk.

By days 2–3 though, I started noticing a shift. Not really hungry, not really full, just… neutral. Eating felt controlled, like I could stop when I actually needed to.

Then the next two mornings I woke up around 4am with headaches (never happens to me), even though I was hydrated and on top of electrolytes.

So yeah, seems like it is working… just not how I expected 😅

Appreciate posts like this; helpful to hear what others experience early on.

Good luck!

Danger1212
 
I started on a low dose for the very first time last week and literally almost immediately, like within a half hour, I felt the effects. It was like a fog (of constant food noise!!) suddenly cleared. The rest of the day I found sticking to my calorie deficit stupidly easy.. I later grabbed a pre-planned snack and forgot to finish it halfway through. That NEVER happens. Then had a take it or leave it attitude about dinner later. Is this how effortlessly thin people go through life!? Amazing stuff.

Alas with the low starting dose, the food noise and genuine actual hunger started ramping back up after a few days. I'm really looking forward to eventually titrating up to whatever dose will work throughout the whole week.
 
cloratheshadow said:
I feel it very fast. Within an hour or two. It will be more intense if you do it in your stomach. You should really feel it the next day 🙂 but once it starts building you’ll feel it all the time even when you need to dose usually
Click to expand...
I don’t pin in my stomach. It hurts more and I prefer less pain. I pin in my outer thighs and feel it just as quickly as when I pinned in my stomach. And I’m more comfortable.
 
After the first shot I could swear it was instant for me, I was 1.5 hr before usual breakfast time when I had the shot and I ate breaffast only after 3 hrs just because it was already 11 AM, I wasn't hungry.

After the second shot it was not until the 2nd day that I felt full effect.

3rd shot coming this Wednesday, we'll see.
 
I have only been on the 2.5mg dose for the past month. I pin midday and feel it by late afternoon early evening, enough to reduce hunger signaling. But by the next day/morning, that's when it's always the most noticeable. So yeah, from the first few hours through the first 24 hours is when I have always most noticed it. And as others have mentioned, it only increases as it compounds with subsequent doses.
 
I started over a year ago with 2.5mg. I could feel it within minutes. Yes, it's a weird feeling, if you've thought about food for 60 years. At the current 19.5mg, it comes on a little slower. One of the first @ 15mg, I caught a little buzz. I still don't know what happened?
 
lil ghost said:
idk if it's a placebo effect or if I'm just a quick responder, but I'm already feeling a complete lack of appetite less than 24 hours after my first pin of tirz. I even started on a low dose (2mg) since I'm on the lower end of the "healthy" BMI range. I could be deluding myself into thinking that I'm not hungry, but it legitimately feels like I'm full despite not eating much today.

This is the very first time I've tried any kind of peptide, so I don't have any personal reference points to compare with my current experience. I'm just curious if anyone else has felt effects kick in right away or if I'm delusional and/or an anomaly.
Click to expand...
It was within 1 day for me. It was also my first peptide of any kind. Idk if I'm a super responder or not. I've been on it for 9 weeks and lost 23 lbs, starting 207, current 184. I'm 5'7" female with an athletic build so I've only got maybe 20 more lbs before I'll be looking really good. I just took my 2nd dose of 7.5mg. I skipped a week of 2.5mg at the beginning.
 
Felt my first 2.5mg dose like within 1 hour, which was weird. After 3rd and 4th pin it took several hours to feel it, and the next day it was full on.
Interestingly, I'm on the 4th day after my 4th pin and felt my stomach rumbling today in the morning for the first time since the beginning of administering Tirz. Yesterday afternoon and evening I was also a little hungrier. All this when was almost sure I was a super responder 😀
btw my BMI was "only" 26.5 when I started, currently at 25.
 
My first 3 pins, I had a reaction to Tirz, at about 18-20 hrs after the shot. 3mg starting dose. A gag-like reflex, I remember standing at the sink, spitting every 10 sec or so, as I couldn't even swallow the saliva in my mouth, which was flowing copiously during the event. Almost puked that first day. 2nd and 3rd pins were more like an upset stomach, like in knots.

I planned my pins from that point forward, to give me time during my workday to deal with it. But after the 3rd pin, it was gone.
 
I was 358 lbs when I started in February at 2.5mg. Took it last thing before bed, woke up, and had to force myself to eat that day and the next day. Felt it full force for over 48 hours straight and some for 6 days. That lasted the first few weeks. Now down 25ish later and a 7.5mg dose, I don't feel it until day 3 or 4 and it only lasts a day or two.
 
I took my first dose of Tirz at 7am. Never eat breakfast. Always ate lunch and started snacking throughout the day and dinner/night.

Realized at 8pm I hadn’t touched any food and don’t have a desire to. I super responded to Tirz. Switched to Reta 6 months later. Still don’t think I respond to it but still at a very low dose. Time will tell. Will probably go back to Tirz.
 
Very quick for me, a couple of hours. Next day could barely eat. In fact started having huel shakes for lunch for first month just to get in some calories and a balanced meal. Couldnt eat much for dinner either and that was at 2.5mg. I stayed on 2.5 for months.
 
thorien said:
Very quick for me, a couple of hours. Next day could barely eat. In fact started having huel shakes for lunch for first month just to get in some calories and a balanced meal. Couldnt eat much for dinner either and that was at 2.5mg. I stayed on 2.5 for months.
Click to expand...
I've also been relying on protein shakes just to get nutrients in. Also, it's crazy how little I think about food now! I used to be such a mindless snacker lol
 
DoctaDave said:
I took my first dose of Tirz at 7am. Never eat breakfast. Always ate lunch and started snacking throughout the day and dinner/night.

Realized at 8pm I hadn’t touched any food and don’t have a desire to. I super responded to Tirz. Switched to Reta 6 months later. Still don’t think I respond to it but still at a very low dose. Time will tell. Will probably go back to Tirz.
Click to expand...
I considered reta, but I read that it could increase heart rate, which freaked me out a little. What made you want to make the switch from tirz to reta in the first place?
 
Started with branded tirz. Effect was noticeable after a few hours.
But in the first week it only worked for 3-4 days. Now after 10+ weeks it last's all week on 3.5mg
 
You must log in or register to reply here.

Trending Topics

Latest Posts

Forum Statistics

Threads
17,724
Posts
184,047
Members
59,548
Newest
Jeffie4k
Back
Top Bottom