How to make a vial last 3 months in the fridge?

[FatPanda]

I might have done something really dumb and could use some advice or reassurance.
I used to take semaglutide (both injections and a compounded version), but the compounded one I was getting stopped working and the lab was shut down for impurities, so I stopped taking it 8 months ago. This is my first time using something that isn’t already compounded or prepared, and I tried to order enough to get me through the first three months.

Because of cost, I only bought one vial of 60mg tirz with bacteriostatic water for mixing. I’m switching to tirz because I want to try something stronger than sema, and my doctor told me I need to either move to injections or consider surgery (I’m 5'5" and 270 lbs).
My plan, if using 1ml of bac water, was:
Month 1: 2.5mg (4 units) weekly
Month 2: 5mg (8 units) weekly
Month 3: 7.5mg weekly
That should use up the 60mg total. I was considering adding more bac water just to be safe if I’m sensitive.
Here’s my concern: storage! I didn't realize it had a shorter shelf life. I’m not sure how long the vial will stay stable after I reconstitute it. I know pens stay good for a few months in the fridge, and my previous compounded vials did too (per my doctor), but is this different with a reconstituted peptide? If I keep it refrigerated and handle it carefully, will it stay good for the full 3 months?
Any insight from people with experience would be hugely appreciated!

 

[bbrewer]

I don't think anybody can predict if it will last 3 months or not. 6 weeks is where I tend to draw the line, but that's not a rule. If it gets cloudy toss it. Always wipe the stopper. If I were in your situation I would put 1.5 months worth in a different vial and freeze it. One freeze thaw cycle will not degrade tirz enough to make any real difference.

 

[byefatlicia]

I would put that in the freezer and obtain a smaller one until titrating up. That's an awful long time. I know the reasoning for 60mg is cost per mg but once you start getting kits from CN, It'll save you tons over single vials and you can get the appropriate mg'd kit for your timeline.
I agree with you about using more Bac for 60mg

 

[latviantower]

Based on the tested ruggedness of the tirz peptide, unless it goes cloudy, you might experience a slight decrease in viability, but it would probably still be pretty good for 3 months. I supply my daughter with 30 mg vials and she’s on 2.5 mg dose, she says month 3 feels like week 1.

I would recon with 2.5 ml BAC for a 60 mg vial. That’s 24 mg/ml concentration. Given the typical 5-10% overfill, 10 units (0.1ml) will easily give you 2.5 mg. (My eyeballs aren’t calibrated enough to see 4 units accurately!)

 

[PopTart]

Based on your titration schedule, it’s actually 11 weeks of refrigeration if your first dose is drawn on the day of reconstitution.

As long as you practice good aseptic techniques, 11 weeks is not a problem.

 

[ZippityDooDah]

How to make a vial last 3 months in the fridge?

Leave it in the fridge for 3 months.

 

[randompersonrandom]

This is why I got a pen and plan to use it when I finish up my brello vials (they're 22mg and I'm currently on 4.4, so no worries about length of time.) I've got two 75mg vials from Olympia to use up after that, and it would probably be fine to just use them. But if I put it in a sterile cartridge and am not letting it be exposed to air in the vial, I feel more safey. (Safey is like truthy, in that it's not necessarily so but feels more so and makes you happier).

 

[indolent]

You're overthinking this.

In the grey community, many many people consider 3 months a reasonable time for refrigeration of tirzepatide. It neither degrades nor becomes less sterile. In fact, prominent compounding pharmacies routinely send out three months' worth at a time, with instructions to refrigerate.

Just always alcohol-swab before each time you puncture the vial.

If you really want to complicate your life, consider freezing between each use. That's an environment which is less friendly to microbial activity. Lab testing on tirzepatide has shown no meaningful degradation with repeated freezing, thawing, and refreezing. It will appear cloudy when frozen, but never when thawed. I've never heard of tirzepatide getting cloudy otherwise.