I did the NAD+ with the full MITO mix: ss-31/MOTSc/NAD+
I did 100 mg MWF
for the term: see below
View attachment 19222
I did take TMG to replenish Methyl
Practical Recommendations for NAD+ & TMG Supplementation
- Timing and Dosage
Based on current knowledge, TMG’s role as a long-acting methyl donor means it can be taken at any time of the day. There’s no evidence to suggest that TMG must be taken at the same time as NAD+. A typical dosage is 1,000mg of TMG daily, which should be more than enough to support methylation needs. However, for individuals who find daily TMG supplementation burdensome, taking it only on the days they use their NAD+ patch is also a viable option.
- Daily vs. Occasional Supplementation
While some patients prefer to take TMG daily, others opt to only take it when using their NAD+ patches. Both methods are acceptable, and individual responses can vary based on personal methylation capacity.
- Methylation Testing
Unfortunately, there aren’t yet precise tests to measure methylation efficiency or NAD+ metabolism in a way that would inform personalized TMG dosing. However, genetic testing for MTHFR mutations and measuring homocysteine levels can provide insight into your methylation capacity.
The Takeaway
While the precise timing and the amount of TMG patients should use with NAD+ are not set in stone, our approach is based on what seems to work for most people: either take TMG daily or on the days when you use NAD+ supplements, especially if you have known methylation issues. You can easily find TMG supplements at online retailers or most vitamin and supplement shops.
At Sellers website, we’ll continue to monitor the latest research and provide updated guidance as more is understood about the interplay between NAD+ and methyl donors like TMG.
Taking
Trimethylglycine (TMG) alongside
NAD+ precursors (like NMN or NR) helps replenish methyl groups, which are depleted during the metabolic process of raising NAD+ levels. This combination supports optimal
methylation, crucial for DNA repair, detoxification, and preventing high homocysteine, often taken together in a 1:1 ratio.
Key Aspects of Combining TMG with NAD+ Boosters:
- Why Combine Them: NAD+ boosters help energy production but can drain the body’s methyl group supply. TMG is a "methyl donor," restoring these groups to keep methylation pathways open.
- Optimal Ratio & Dosage: Experts, including Dr. David Sinclair, often recommend a 1:1 ratio of TMG to NMN/NR, commonly around
View attachment 19219When to Take: TMG can be taken in the morning, often with food to maximize absorption and prevent stomach discomfort.
View attachment 19221
of TMG daily.
- Synergy: While NMN/NR directly raises NAD+, TMG ensures the metabolic process does not cause long-term depletion of methyl groups, supporting, overall, cellular health.
- Benefits: Potential benefits include sustained energy, improved cardiovascular health, and better methylation, with significant improvements often reported after 3-6 months.
