I have Afib with RVR. What has been your experience been with increased heartrate from Reta?

Mine is similar, I haven’t seen anything indicating this is a problem, have you?
I'm a girl, they just said it's anxiety. 🤷‍♀️ It's just below concerning level, so I think it's withing normal bounds.
 
people can take nebividol to tamp it down.
Note that I have zero medical training but Primum Non Nocere is a doctor and posted a multi-post writeup on this topic on The Roundtable. This a paraphrase from his post.

The glucagon-like-effect of Reta is what raises your heart rate. Nebivolol is a beta blocker which is a different channel. Glucagon is one of the meds that can be used in the ER to treat overdoses of beta and calcium channel blockers. While these meds can lower your baseline heart rate the glucagon-like-effect of Reta could actually counteract these meds from lowering you heart rate.

I know someone is going to ask for references so here you go: (he always provides them)

Glucagon mode of actionhttps://www.vumc.org/poison-control...why-do-we-give-glucagon-beta-blocker-overdose

BB and CCB toxicity and treatment optionshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767195/


 
yea, that's why i say it tamps it down. doesn't aleviate.

i take a full 20 mg nebivolol.
Damn!

I was on 2.5mg 2x and my BP was borderline low (90/60) so I couldn't really increase my dosage. A month or two ago I switched to metoprolol 25mg 2x and I am experimenting with substituting 20mg of propranolol for my morning dose every few days. The propranolol works great and better than the other two, but I don't think I want to switch to it 100% because of the side effects and I think its pretty hard on the liver.

I make the changes and let my cardiologist and electrophysiologist know when I have appointments with them. They are both like, "whatever works".
 
so i wonder and believe that heart rate has to go up to get energy burning and fat burning effect.

so if i take reta and a bunch of beta blockers what's the advantage of reta?
 
so i wonder and believe that heart rate has to go up to get energy burning and fat burning effect.

so if i take reta and a bunch of beta blockers what's the advantage of reta?
I don't know for sure, but I don't think is how it works.

If your heart rate sitting on the couch is 60 and mine is 90, I don't think I am burning more calories than you (other than the minuscule amount of calories burned by my heart muscles to incrementally beat more than yours).
 
if my heart rate goes from 60 to 90 i think i have to be burning more energy.

can't break the laws of physics. captin.

but maybe its not that much. a good subject to research further.
 
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Has anyone that had this the jump in RHR on R3ta stayed the course and had your RHR come back down over time? I ask because mine jumped from upper 60s to 120 over the first few hours and has gradually come down to 105 over a few weeks. If I give up on R3ta, I am going to T1rz which hasn't had the RHR side effect but doesn't have the added GCG agonist that R3ta does. I would rather stay the course if at all possible
 
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Has anyone that had this the jump in RHR on R3ta stayed the course and had your RHR come back down over time? I ask because mine jumped from upper 60s to 120 over the first few hours and has gradually come down to 105 over a few weeks. If I give up on R3ta, I am going to T1rz which hasn't had the RHR side effect but doesn't have the added GCG agonist that R3ta does. I would rather stay the course if at all possible
This is the biggest increase in RHR that I have heard about. Being consistently over 100bpm RHR would concern me. Make sure you are staying in sinus rhythm. Don't want to stroke out due to afib.
 
This is the biggest increase in RHR that I have heard about. Being consistently over 100bpm RHR would concern me. Make sure you are staying in sinus rhythm. Don't want to stroke out due to afib.
Absolutely on top of that and watching. This is more of a flutter. Stable rhythm and steady, but faster than normal. I'm about to call it and switch over to T1rz thaat doesnt have the cardiac side effect issues
 
Please report back on your survodutide experience please. I’m reading it acts like Reta minus increased heart rate. Curious to hear from those that have tried it.😉
I saw a suggestion on another discussion to do the Tirz, which has a light GLP-1 and a strong GIP , but no GCG agonist. Then add on a small dose of Survo which has a strong GLP-1, no GIP, and a good GCG, and no RHR side effects. Interesting.
 
I saw a suggestion on another discussion to do the Tirz, which has a light GLP-1 and a strong GIP , but no GCG agonist. Then add on a small dose of Survo which has a strong GLP-1, no GIP, and a good GCG, and no RHR side effects. Interesting.
I had atrial flutter before a cardiac ablation back in May, started Tirz in late-July it raised my HR about 10bpm on average. In Feb, I did a slow swap from Tirz to Reta and just went to 5mg reta and last small dose of Tirz was three weeks ago. My non-RHR seems to be 5-10bpm higher this week. Mid-80's to mid-90's most of the day and RHR is up a couple of BPM. I am going to drop back to 4mg to see if I can get it to go back down. I am now in maintenance so I have the flexibility to play with the dose.
 
I saw a suggestion on another discussion to do the Tirz, which has a light GLP-1 and a strong GIP , but no GCG agonist. Then add on a small dose of Survo which has a strong GLP-1, no GIP, and a good GCG, and no RHR side effects. Interesting.
This is what I’d do if looking to add to Tirz. Or small dose of Sema.
 
I wasn't concerned initially concerned about Reta & increased heart rate but now I'm wondering. I plan on starting my Reta soon, but kind of concerned since my RHR is average between 86-90. I may have to re- evaluate.
 
I have afib w/rvr and my heart rate has not increased at all.
I should explain a bit. Got the first episode in July 2017. Had an ablation in October that year. Was already taking propranolol 160 for migraines and anxiety. Then in November of 2021, had a second attack. The cardiologist started me on flecainide and I’ve been good since. My Heart rate doesn’t seem to react much to drugs tho- I had to wait to take propranolol, was titrated up because my resting heart rate has always been in the 50’s. Well, aside from the episodes of afib before the ablation and in November ‘21. I just checked my heart rate and I lied. It’s now low 60’s apparently. 63. But yeah, my heart rate didn’t jump that much.
 

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