I miss the nausea

[SlimReaper]

So I don't know if I screwed up but I was titrating up like almost every week, from 2.5mg tirzapetide to 15mg. Its taken me under 3 months to get to 15mg. The lower doses were absolutely amazing, I was eating once every 2 days. Ever since like 12mg, there's no more nausea. The nausea was preventing me from eating but with it gone, the tirzapetide just doesn't feel as strong anymore. I also seem to be hungrier more often. I have heard of people experiencing this as well but only after being on it for about a year. Not sure what I should do, maybe take a break? Its the T60 from amopure/amolist.

 

[Superfluous]

I don't think eating once every 2 days is actually healthy. If you're coming from a heavy weight/obese position you'll end up with flabby skin issues if you lose too quick. if you're coming from an 'overweight' position you'll lose muscle and generally weaken your body.

Anyway yes as I've become more used to this drug there are frequent times when the 'food noise' comes back - but even then when I eat (or drink fluids) I become fuller faster. And I believe this is the key to longevity on this stuff - you still eat, but just less on average.

 

[normal]

That seems a little bit borderline eating disorder-ish to want to be legitimately so nauseous for days that you dont want to eat, but you do you. You may be the first person who actually wanted that side effect lmao

Do you mean food aversion or straight nausea?

 

[lrossetto0722]

So I don't know if I screwed up but I was titrating up like almost every week, from 2.5mg tirzapetide to 15mg. Its taken me under 3 months to get to 15mg. The lower doses were absolutely amazing, I was eating once every 2 days. Ever since like 12mg, there's no more nausea. The nausea was preventing me from eating but with it gone, the tirzapetide just doesn't feel as strong anymore. I also seem to be hungrier more often. I have heard of people experiencing this as well but only after being on it for about a year. Not sure what I should do, maybe take a break? Its the T60 from amopure/amolist.

You wanna be nauseous? I got some cagrisema you can have!! 😆

 

[Goreandglitter]

I’m glad your eating disorder clearing up…. This was super unhealthy.

 

[SlimReaper]

That seems a little bit borderline eating disorder-ish to want to be legitimately so nauseous for days that you dont want to eat, but you do you. You may be the first person who actually wanted that side effect lmao

Do you mean food aversion or straight nausea?

Yeah I think I'm just saying the wrong thing. Its more so the food aversion / slowing digestion. I feel like I can eat as much / as often as if I'm not on tirzapetide. I will feel terrible after doing so, but before on the lower doses of tirz it wouldn't let me do that at all.

Example I ate an entire bag of tortilla chips with salsa on 12.5mg of tirz, which would never have happened on the earlier doses.

Also I will say I've been plateu'd for about a month now at 255, from 290.

 

[normal]

Yeah I think I'm just saying the wrong thing. Its more so the food aversion / slowing digestion. I feel like I can eat as much / as often as if I'm not on tirzapetide. I will feel terrible after doing so, but before on the lower doses of tirz it wouldn't let me do that at all.

Example I ate an entire bag of tortilla chips with salsa on 12.5mg of tirz, which would never have happened on the earlier doses.

Why did you blast all the way up to almost max dose at 4x the regular dosing schedule if you were getting the effects and weight loss you wanted at lower doses?

 

[SlimReaper]

Why did you blast all the way up to almost max dose at 4x the regular dosing schedule if you were getting the effects and weight loss you wanted at lower doses?

Yeah I just followed the logic of more = better. I tried looking for reports of anything negative and I didn't see people mention that it could result in less efficacy. I was getting good results with almost no negative sides besides the nausea. Probably a mistake tbh.

 

[Dee X]

Example I ate an entire bag of tortilla chips with salsa on 12.5mg of tirz, which would never have happened on the earlier doses.

Also I will say I've been plateu'd for about a month now at 255, from 290.

Might have something with you eating an entire bag of tortilla chips with salsa.

 

[Valerie]

Yeah I think I'm just saying the wrong thing. Its more so the food aversion / slowing digestion. I feel like I can eat as much / as often as if I'm not on tirzapetide. I will feel terrible after doing so, but before on the lower doses of tirz it wouldn't let me do that at all.

Example I ate an entire bag of tortilla chips with salsa on 12.5mg of tirz, which would never have happened on the earlier doses.

Also I will say I've been plateu'd for about a month now at 255, from 290.

It sounds like it was easier for you when you felt too sick to eat. Now with some healthy food noise you're going back to poor eating habits rather than choosing better options? Do you mean you feel guilty or physically ill or both after the chips? I can't eat chips on tirz; my stomach can't take it.

Perhaps consider a nutritionist to learn some delicious food options that satiates you and allows you lose wt, and perhaps some talk therapy to get to the root of the issue. I agree with the other comments ; eating every two days isn't healthy or sustainable.

 

[cldfront]

I have heard that if you take a 4-6 week break you can reset the receptors. I'd pause for 4 weeks and then start again at 2.5mg and make sure you give it a full week before increasing in .2mg steps at the most. The other people who have experience this at a year have taken a full year to titrate up to 15mg, unfortunately.

 

[keangkong]

People who took 15 mg of tirzepatide lost the most weight. That continued to be true even after more than 3 years of taking tirzepatide. I'm hesitant about the resetting of receptors theory to get better weight loss.

 

[cldfront]

People who took 15 mg of tirzepatide lost the most weight. That continued to be true even after more than 3 years of taking tirzepatide. I'm hesitant about the resetting of receptors theory to get better weight loss.

Yeah, my thoughts are purely speculation - have not tried/experienced taking a break, however a quick google search will say that if you stop taking it for some reason you need to start with 2.5mg again instead of picking up where you left off.
Just something to consider!

 

[SlimReaper]

People who took 15 mg of tirzepatide lost the most weight. That continued to be true even after more than 3 years of taking tirzepatide. I'm hesitant about the resetting of receptors theory to get better weight loss.

Well I just took a new shot from a fresh vial today, 15mg. Thinking about food makes me want to throw up so I'm wondering if maybe I just had a bad vial. I was on that vial for 3 weeks, threw it away 1 week early. I'll keep this thread posted if anything changes but it seems the food aversion is back. Thanks everyone.

Also I forgot to mention but I don't store my tirz in the freezer, its only a 8 month batch. From what I've read that is not enough to degrade stored at room temp in a cool dark dry place. That was another thing that was worrying me, if I had killed my tirz.

 

[geoguy78]

Sounds to me like you rushed so fast to get from Point A to Point B that you didn't get to enjoy the trip. You should have spent a minimum of four weeks on each dosing step. It takes about five weeks for the level of tirzepatide in your body to reach peak levels at any specific dose. Ive spent 6+ weeks at dosage steps and I'm going up in 0.5mg increments right now. The way you went about this, you've probably lost a fraction of weight compared to what you would have lost by the time you reached 15mg the right way, at month six or later. Instead you've absolutely saturated your GLP-1 and GIP receptors, and who knows what you've done to your metabolism. And now that you rushed to the finish line so fast, you've basically got zero options, or at least zero good options. What's next? Start stacking reta so fast you have a heart attack? You need to take a step back and use your head here. Me personally I'd stop cold turkey for a receptor reset and try again the right way. Chances are you'll gain a bunch of weight back though. Also, extreme nausea isn't how these meds are intended to work

 

[keangkong]

Well I just took a new shot from a fresh vial today, 15mg. Thinking about food makes me want to throw up so I'm wondering if maybe I just had a bad vial. I was on that vial for 3 weeks, threw it away 1 week early. I'll keep this thread posted if anything changes but it seems the food aversion is back. Thanks everyone.

Also I forgot to mention but I don't store my tirz in the freezer, it’s only a 8 month batch. From what I've read that is not enough to degrade stored at room temp in a cool dark dry place. That was another thing that was worrying me, if I had killed my tirz.

Being nauseous is often a sign you’re taking too much torz.

 

[Dee X]

Being nauseous is often a sign you’re taking too much torz.

And / or eating things (or quantities) you shouldn't be eating.

What's your daily caloric intake, @SlimReaper? What does your overall daily diet look like?

 

[zpped]

You need psychological help before you continue trying to manage your own medication. You very clearly have something else going on and are going to hurt yourself if you don't stop.

 

[SlimReaper]

And / or eating things (or quantities) you shouldn't be eating.

What's your daily caloric intake, @SlimReaper? What does your overall daily diet look like?

Chicken and rice mainly. Maybe a meatloaf with a side of corn. Every other day. So maybe 800-1000 calories a day on average.

Sounds to me like you rushed so fast to get from Point A to Point B that you didn't get to enjoy the trip. You should have spent a minimum of four weeks on each dosing step. It takes about five weeks for the level of tirzepatide in your body to reach peak levels at any specific dose. Ive spent 6+ weeks at dosage steps and I'm going up in 0.5mg increments right now. The way you went about this, you've probably lost a fraction of weight compared to what you would have lost by the time you reached 15mg the right way, at month six or later. Instead you've absolutely saturated your GLP-1 and GIP receptors, and who knows what you've done to your metabolism. And now that you rushed to the finish line so fast, you've basically got zero options, or at least zero good options. What's next? Start stacking reta so fast you have a heart attack? You need to take a step back and use your head here. Me personally I'd stop cold turkey for a receptor reset and try again the right way. Chances are you'll gain a bunch of weight back though. Also, extreme nausea isn't how these meds are intended to work

I understand some concern but this is a bit of an extreme. I never titrated up without feeling well adjusted to the dose. I'm just like the rest of yall in the sense that I can eat small portions before feeling full and only sometimes nauseous. Again, its taken 3 months to get to 15mg, whereas normally it would take 6.

 

[normal]

I haven't felt nauseous since my 2nd day of tirz and am on like week 27 or something, at 15mg every 6 days, about 80lbs down. Feeling nauseous before or after eating sounds absolutely miserable. I don't think you're experiencing the same thing we all are. I think you're getting blasted by a side effect most people intend to avoid at all costs from blazing up too fast, and have mentally turned that side effect into a goal for the meds to achieve. You literally said in your first post the nausea was so great, you would only eat once every two days. And you were chasing feeling nauseous. That's a brewing eating disorder my man, denial is okay but take a mental note and come back to this at some point.

The title of this post is "i miss the nausea".

Again, take a mental note and come back to this post later.

You can experience all of your goals without feeling like you want to puke and starving yourself for days on end. Fasting is normal. 800 (let's be real, maybe) calories every two days because you feel so nauseous you can't eat isn't normal.

Do i think the tirz gonna hurt you? I'm not a dr lol but I doubt it. Do I think it's causing you borderline an eating disorder? Yeah. Is that going to hurt you? Long term, possibly if it doesn't get under control or escalates. Does my opinion matter? Not really.

 

[YoYoFat]

Well I just took a new shot from a fresh vial today, 15mg. Thinking about food makes me want to throw up so I'm wondering if maybe I just had a bad vial. I was on that vial for 3 weeks, threw it away 1 week early. I'll keep this thread posted if anything changes but it seems the food aversion is back. Thanks everyone.

Also I forgot to mention but I don't store my tirz in the freezer, its only a 8 month batch. From what I've read that is not enough to degrade stored at room temp in a cool dark dry place. That was another thing that was worrying me, if I had killed my tirz.

Were you using a 60mg vial?

 

[geoguy78]

I understand some concern but this is a bit of an extreme. I never titrated up without feeling well adjusted to the dose. I'm just like the rest of yall in the sense that I can eat small portions before feeling full and only sometimes nauseous. Again, its taken 3 months to get to 15mg, whereas normally it would take 6.

Dude, you titrated up every week! How you felt doesn't matter, the levels of peptide in your body never stabilized and the peptide never got a real chance to do its job

 

[Lullabytreehugger]

I have heard that if you take a 4-6 week break you can reset the receptors. I'd pause for 4 weeks and then start again at 2.5mg and make sure you give it a full week before increasing in .2mg steps at the most. The other people who have experience this at a year have taken a full year to titrate up to 15mg, unfortunately.

Too long. When I had horrible sides with sema at a dose of 1.5mg once a week. I have never had diarrhoea and vomiting at the same time. It was really bad. I cut sema out completely for 2 weeks. Had zero chemicals in me. But guess what? I dropped 3kgs?! Like what?! Then I felt weird without sema so I reintroduced it with micro dose of 0.15mgs. No further weight loss occurred after readminstration …

 

[mopo89]

Sounds to me like you rushed so fast to get from Point A to Point B that you didn't get to enjoy the trip. You should have spent a minimum of four weeks on each dosing step. It takes about five weeks for the level of tirzepatide in your body to reach peak levels at any specific dose. Ive spent 6+ weeks at dosage steps and I'm going up in 0.5mg increments right now. The way you went about this, you've probably lost a fraction of weight compared to what you would have lost by the time you reached 15mg the right way, at month six or later. Instead you've absolutely saturated your GLP-1 and GIP receptors, and who knows what you've done to your metabolism. And now that you rushed to the finish line so fast, you've basically got zero options, or at least zero good options. What's next? Start stacking reta so fast you have a heart attack? You need to take a step back and use your head here. Me personally I'd stop cold turkey for a receptor reset and try again the right way. Chances are you'll gain a bunch of weight back though. Also, extreme nausea isn't how these meds are intended to work

Agreed. We're not supposed to feel nauseous all the time. That sounds like a miserable existence!

While I think GLP1s are a great tool in helping with overeating and other food disorders, they're not a cure. You should be using GLP1s in conjunction with other tools (therapy, etc) to get to the root of your habits and be able to change them. Otherwise, GLP1s are really just a bandaid and not a solution.

 

[keangkong]

Agreed. We're not supposed to feel nauseous all the time. That sounds like a miserable existence!

While I think GLP1s are a great tool in helping with overeating and other food disorders, they're not a cure. You should be using GLP1s in conjunction with other tools (therapy, etc) to get to the root of your habits and be able to change them. Otherwise, GLP1s are really just a bandaid and not a solution.

If GLP-1s are a Band-Aid, they're an extremely powerful Band-Aid.

 

[SlimReaper]

Were you using a 60mg vial?

That's right

 

[Superchicken1]

Taking breaks and restarting has clinically shown that the last effective dose typically no longer works. You still are supposed to start at the beginner doses and titrate up though. Something to keep in mind if you take a break.

 

[cldfront]

Taking breaks and restarting has clinically shown that the last effective dose typically no longer works. You still are supposed to start at the beginner doses and titrate up though. Something to keep in mind if you take a break.

Can you site this "clinically shown" information?

 

[maryannesk]

So I don't know if I screwed up but I was titrating up like almost every week, from 2.5mg tirzapetide to 15mg. Its taken me under 3 months to get to 15mg. The lower doses were absolutely amazing, I was eating once every 2 days. Ever since like 12mg, there's no more nausea. The nausea was preventing me from eating but with it gone, the tirzapetide just doesn't feel as strong anymore. I also seem to be hungrier more often. I have heard of people experiencing this as well but only after being on it for about a year. Not sure what I should do, maybe take a break? Its the T60 from amopure/amolist.

I haven't had good luck with Amopure. I bought it November. No food aversion at all. No weight loss. I don't think it's a good source.

 

[geoguy78]

I haven't had good luck with Amopure. I bought it November. No food aversion at all. No weight loss. I don't think it's a good source.

The 40+ pounds I've lost since September from Amopure T30 say otherwise

 

[zpped]

I haven't had good luck with Amopure. I bought it November. No food aversion at all. No weight loss. I don't think it's a good source.

What did the test say? You tested it, Right?

 

[geoguy78]

What did the test say? You tested it, Right?

We live in a vibes-based reality these days

 

[Windingroads06]

I have had an unintentional, forced wash out. I was stopped on 10mg due to insurance and I had not found alternative sources. I regained 10# that it took me 3 months to lose once I had restarted.
When I restarted, I started at 5mg and advanced 2.5mg every four weeks until I reached 10mg. I have no plans to go higher until I have plateaued for at least two months on 10.

My loss has been slow but steady.

 

[keangkong]

I don't miss the nausea, which, by the way, I rarely experienced. I don't miss the constipation at all, even though after several months it finally disappeared. I don't miss the diarrhea. I also don't miss the chills, which are just as severe if not more severe as earlier.

 

[mlke6]

Agreed. We're not supposed to feel nauseous all the time. That sounds like a miserable existence!

While I think GLP1s are a great tool in helping with overeating and other food disorders, they're not a cure. You should be using GLP1s in conjunction with other tools (therapy, etc) to get to the root of your habits and be able to change them. Otherwise, GLP1s are really just a bandaid and not a solution.

same with people who need blood pressure meds? Insulin?

 

[chmuse]

same with people who need blood pressure meds? Insulin?

Depends on why you need the meds- and there are a wide variety of reasons to take them. If you have type 2 diabetes, if you change your diet, you require less insulin. If you have high blood pressure, they may tell you cut down on salt. Suggesting that is good medicine.

There ARE purely physical reasons for needing them- PCOS, poor metabolism, some people are missing the biological cues to stop eating. But I doubt there's a single person here who couldn't benefit from therapy and learning to make healthier choices. And we're all on a modern diet, we would all benefit from cutting out processed foods.

There is a very good chance we will all be on these medications for life, just like a diabetic. But suggesting to rely solely on a medication that often loses efficacy over time is just a bad idea. The OP is literally about missing the nausea- the medication is already working differently for them. Not learning healthy habits to go along with the medication is most likely just a band aid, and when the medication stops giving you those side effects, what will you do if you're still used to eating a big mac every day? You'll end up eating the entire thing like you used to instead of the half you could handle in the early days of glp1 usage, and now you have to change your habits without the benefit of a medication that makes that manageable.

Medications are rarely the only thing you're supposed to do for a medical issue. Diet and lifestyle changes are almost always suggested in conjunction.

Edited to hopefully come across less bitchy.

 

[SCDC1]

So I don't know if I screwed up but I was titrating up like almost every week, from 2.5mg tirzapetide to 15mg. Its taken me under 3 months to get to 15mg. The lower doses were absolutely amazing, I was eating once every 2 days. Ever since like 12mg, there's no more nausea. The nausea was preventing me from eating but with it gone, the tirzapetide just doesn't feel as strong anymore. I also seem to be hungrier more often. I have heard of people experiencing this as well but only after being on it for about a year. Not sure what I should do, maybe take a break? Its the T60 from amopure/amolist.

You need to eat healthy and often. You will eventually cause permanent organ damage by starving your body. If you want to eat only once every few days, you need to see your Dr.. That's a big problem.

 

[normal]

The 40+ pounds I've lost since September from Amopure T30 say otherwise

Same. I'm down 40 from Strive compounded, and 60+ more gone from Amo T30.

 

[chmuse]

That's a lot... And I agree. I think the point @mlke6

Thank you 🥲😅 I need to learn to be concise.

 

[nonyabizznez]

Thank you 🥲😅 I need to learn to be concise.

I hadn't finished but can't delete because you quoted it 🤬

 

[nonyabizznez]

What I meant to say in agreement with @mlke6:

Piling years of Oprah weight loss shows, Weight Watchers, Nutrisystem, therapy and gym commercials and guilt about your relationship with your mother doesn't change this fact:
Some who are obese can take a GLP-1 and get to a healthy BMI. No gym, no rehab, no therapy, no diet. And provided they continue with their GLP-1 they can maintain it. Just as one manages diabetes, high blood pressure etc obesity can be managed.

If the above ain't true than I don't exist cuz I wrote the book on it... And it's one sentence long... "I take a weekly shot"... That's it! 😁

 

[Windingroads06]

... Not learning healthy habits to go along with the medication ....

Is dumb

....medications are rarely the only thing you're supposed to do for a medical issue. Diet and lifestyle changes are almost always suggested in conjunction.

Absolutely this!!!

While I have been told this is a lifetime of medication, I am taking steps to be better without medication.

Any doctor worth their salt should advise you to consult with a nutritionist or a dietician and begin a regimen of physical activity, assuming you are healthy enough to do so.

Medication alone won't fix our problems.

 

[chmuse]

Is dumb

Absolutely this!!!

While I have been told this is a lifetime of medication, I am taking steps to be better without medication.

Any doctor worth their salt should advise you to consult with a nutritionist or a dietician and begin a regimen of physical activity, assuming you are healthy enough to do so.

Medication alone won't fix our problems.

That entire comment really could have been truncated to two sentences 😂😂 In my defense it was 7 am so I was rambling.

What I meant to say in agreement with @mlke6:

Piling years of Oprah weight loss shows, Weight Watchers, Nutrisystem, therapy and gym commercials and guilt about your relationship with your mother doesn't change this fact:
Some who are obese can take a GLP-1 and get to a healthy BMI. No gym, no rehab, no therapy, no diet. And provided they continue with their GLP-1 they can maintain it. Just as one manages diabetes, high blood pressure etc obesity can be managed.

If the above ain't true than I don't exist cuz I wrote the book on it... And it's one sentence long... "I take a weekly shot"... That's it! 😁

Yes! For some people it will work like that. But this thread is specifically about someone relying on a negative side effect like some sort of pavlovian self training. It's unhealthy, OP does need to get to the root of why they need to feel nausea to lose weight. I think that was @mopo89 point, and responding to her comment to ask about freaking insulin like it's the same situation is missing the point being made.

 

[nonyabizznez]

That entire comment really could have been truncated to two sentences 😂😂 In my defense it was 7 am so I was rambling.

Yes! For some people it will work like that. But this thread is specifically about...

Oh...so now we can only respond to the specific thread topic? Lemme fix it:

If the above ain't true than I don't exist cuz I wrote the book on it... And it's one sentence long... "I take a weekly shot"... That's it! 😁 And if ya miss the nausea take more!

 

[chmuse]

Oh...so now we can only respond to the specific thread topic? Lemme fix it:

If the above ain't true than I don't exist cuz I wrote the book on it... And it's one sentence long... "I take a weekly shot"... That's it! 😁 And if ya miss the nausea take more!

Point taken, I'm being a little bitchy today. 😬 I'll tap out.

 

[nonyabizznez]

Point taken, I'm being a little bitchy today. 😬 I'll tap out.

No worries 🥰... Sometimes problems have simple solutions. I think it's pretty obvious that not having nausea is not the OP's problem.

Now let's see if Taylor Swift grabs the mic like Kanye and takes over for Kendrick Lamar 🎤🏈

 

[Windingroads06]

Point taken, I'm being a little bitchy today. 😬 I'll tap out.

I've had to do that some.

 

[chmuse]

No worries 🥰... Sometimes problems have simple solutions. I think it's pretty obvious that not having nausea is not the OP's problem.

Now let's see if Taylor Swift grabs the mic like Kanye and takes over for Kendrick Lamar 🎤

So.... Did she? 😂

 

[hotdog!]

I read the poor girl got booed when the camera put her on screen. I never understood either extreme on this girl, but especially the haters because it seems so rooted in misogyny. Like, if she and her music are so lame, why expend so much energy on hating her? It's like kicking a little girl who made millions singing songs about puppies. I might think it's lame but why not just roll my eyes and keep walking.

 

[chmuse]

I read the poor girl got booed when the camera put her on screen. I never understood either extreme on this girl, but especially the haters because it seems so rooted in misogyny. Like, if she and her music are so lame, why expend so much energy on hating her? It's like kicking a little girl who made millions singing songs about puppies. I might think it's lame but why not just roll my eyes and keep walking.

Exactly! She's writing pop music, not trying to run for the oval office.

Oh...so now we can only respond to the specific thread topic? Lemme fix it:

If the above ain't true than I don't exist cuz I wrote the book on it... And it's one sentence long... "I take a weekly shot"... That's it! 😁 And if ya miss the nausea take more!

I must be in a better mood today, I'm derailing threads again.