If you were a newb... would you start with Tirz or Reta first?

[zpped]

They extended the reta stage 3 trials past the original end date - presumably to get more data on how much weight is actually lost - but they would have stopped the trials if they had encountered any significant health risks, no? Like we saw with azalaprag?

Correct. The stage 3 trials have been a huge success. They transitioned everyone from the placebo onto reta already.

 

[Nmc110662]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

Tirzepatide

 

[LetsMakeMayhem]

I’d look at it the same way I’d look at dosage increases. Start with what’s considered the weakest or lightest, and go from there.

Well, ironically enough I was lucky to catch 30mg Tirz on presale, so I went with that. I imagine it will last me a WHILE.

 

[beefsteak]

I'd start with reta and then tirz for maintenance once I reach goal weight.

Currently 7 months into tirz, 7mg, and starting reta soon. Losing about 6-8lb/month. I feel like transition to reta is going to be a pain in the ass.

 

[dogmom]

reta

 

[keangkong]

They extended the reta stage 3 trials past the original end date - presumably to get more data on how much weight is actually lost - but they would have stopped the trials if they had encountered any significant health risks, no? Like we saw with azalaprag?

I agree that Eli Lilly extending the trials suggests good results in the stage 3 trials so far. Still we are talking about studies that have not yet completed.

 

[m100568]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

Just my personal opinion. . . Reta at low doses doesn't have as good appetite suppression. But, I love the active fat burning. I would, and have, stacked Tirz and Reta. Reports are that when you hit 6mg of Reta and above the appetite suppression kicks in and you can transition fully to Reta. I took a different route that worked for me, but I'm just experimenting. I went all the way up to 15mg on Tirz and slowly titrated up to 5mg on Reta. The appetite suppression was so strong I could only stand it for 2 weeks. I then started titrating down on Tirz and up on Reta. I'm currently at 12mg Reta and 4mg Tirz. Honestly, I think I could stop the Tirz, but I have so much of it that I am continuing to use it in small amounts. I may drop the Tirz to 2mg in the near future if the Reta continues to give me strong appetite suppression. By the way, the only real side effects I had was when I went from 5mg Tirz to 7.5mg Tirz (massive fatigue for 2 days), and when I jumped from 1mg Reta to 3mg Reta (diarrhea for a week).

 

[FlowerFairy]

Just my personal opinion. . . Reta at low doses doesn't have as good appetite suppression. But, I love the active fat burning. I would, and have, stacked Tirz and Reta. Reports are that when you hit 6mg of Reta and above the appetite suppression kicks in and you can transition fully to Reta. I took a different route that worked for me, but I'm just experimenting. I went all the way up to 15mg on Tirz and slowly titrated up to 5mg on Reta. The appetite suppression was so strong I could only stand it for 2 weeks. I then started titrating down on Tirz and up on Reta. I'm currently at 12mg Reta and 4mg Tirz. Honestly, I think I could stop the Tirz, but I have so much of it that I am continuing to use it in small amounts. I may drop the Tirz to 2mg in the near future if the Reta continues to give me strong appetite suppression. By the way, the only real side effects I had was when I went from 5mg Tirz to 7.5mg Tirz (massive fatigue for 2 days), and when I jumped from 1mg Reta to 3mg Reta (diarrhea for a week).

I’m only at 6 mg Reta and I have no food noise. I was stacking Tirz and Reta to start- 2reta w/4 Tirz- transitioned to Reta 4, then 6 when I ran out of Tirz. But I’m one person.

 

[Edboy]

Started reta 2 months ago. Worse sides was sulfur burps, and skin tingles; subsided by week 6.

 

[Wellwell]

I'm currently at 15mg tirz, at a stall. Stack cagri .125 to get to goal. I have reta in the freezer. I won't stack 2 GLP1s, so I have to determine how I'll try reta in maintenance. Thanks

What reason are you against stacking two glp? I've seen some are against it but have not seen a reason why.

 

[catdog]

What reason are you against stacking two glp? I've seen some are against it but have not seen a reason why.

I have read some say that the efficacy of one GLP is decreased by another - to be honest though, not sure how true or sensible that is given that the same receptors are being targeted, but who knows. No research has been published on the subject. Just anec data.

 

[hexagonal]

What reason are you against stacking two glp? I've seen some are against it but have not seen a reason why.

Quite simply:

We have no idea what the outcome is outside of anecdotal reports. No studies are researching what happens, we have no human clinical trial data around it, etc. We know that stacking multiple types of the same drug is often a bad thing. The receptor agonism is balanced in a specific way with the formulation of the drugs in general. Is it safe short term? Long term? What side effects are there?

Lots of people seem to be doing it just fine, so maybe it is fine. But maybe it isn't.

 

[janedoe]

What reason are you against stacking two glp? I've seen some are against it but have not seen a reason why.

As others pointed out, No studies indicate either way. My research leads me to my own research use. I, personally, anecdotally, don't want to over load receptors, with the same chemical, from 2 items. It may be moot, or not, but that's what my conclusion is, for me. Many research the opposite, and that is good for them. There's no way to tell. Grey research is diffrent for everyone. 👍