If you were a newb... would you start with Tirz or Reta first?

[TooBigtoFail]

Tirz again. Is price a concern? How much weight? Not everyone reacts the same. Don't buy 5-10mg vials. Go higher content 30 or 50mg. Buy one kit (10 vials) and stretch each vial for 6-8 weeks. Should be good for almost one year. Never tried Sema. 38 weeks on Tirz. 60# gone. 0 exercise. Stacking Cagri and Reta.

 

[Ted R]

Sema did nothing for me except give me constipation. Tirz was good but made some foods taste funny (coffee didn’t taste right, steak was meh, tomatos didn’t taste right). Because of all the odd effects on stuff I love, I lived on protein shakes and vitamin/mineral supplements. They didn’t taste great, but nothing tasted good anyway. Then I learned about Reta. Oh lawd I can enjoy coffee again. My ribeye tastes good again. My salads- fabulous! ….except I still have to make myself eat. Nothing sounds good right now. It’s great when I break down and make it, but I just.. don’t wanna bother.. unless it’s coffee. I love my coffee.
But to answer your question? Reta. If it doesn’t kick your tail heart rate wise, it would be my choice. And start on a bowel regimen before you think you have a problem, ok?

Reta was definitely my first choice, and still would be, but things don't always work out like you hoped. The Tirz/Survo stack is my just work around that gives me most benefits of the Reta regimen, and with the bowels, drink those 8 glasses of water a day. Makes a huge difference.

 

[FlowerFairy]

Reta was definitely my first choice, and still would be, but things don't always work out like you hoped. The Tirz/Survo stack is my just work around that gives me most benefits of the Reta regimen, and with the bowels, drink those 8 glasses of water a day. Makes a huge difference.

Yeah I feel fortunate that I can use it. So sorry that it affected you that way!

 

[grades]

I’d look at it the same way I’d look at dosage increases. Start with what’s considered the weakest or lightest, and go from there.

 

[hexagonal]

My RHR is average 80s. That is scary to have that high a jump..

Most people won't have it jump that high, thankfully. Some people do, though, so I'd recommend starting low and slow and increasing gradually.

My RHR is on the high side in general, sits in the 90s with everything I'm taking.

 

[onepotatotwopotato]

I'd start with tirz. Seems effective enough with more research behind it, you'll find a lot more information online about it, drs know more about it (if you need help) and it's reasonably priced these days

 

[janedoe]

Yep. It wasn't fun. One thing I was recommended to try with the Tirz after a few weeks was add 1mg of Survo 3 days after every Tirz. Adds more GLP-1 and Glucagon which makes it work a lot like Reta without the cardiac side effect and helps with the food noise. Absolutely happy with that so far. Problem is, one-size-fits-all doesn't work well in this research effort.

I'm currently at 15mg tirz, at a stall. Stack cagri .125 to get to goal. I have reta in the freezer. I won't stack 2 GLP1s, so I have to determine how I'll try reta in maintenance. Thanks

 

[janedoe]

Not everyone will have that jump. Had one at first but resolved over time.

Ah. Ok... good to know.

 

[keangkong]

I recommend starting with tirzepatide. From the stage 2 trials, it looks like reta will be safe and effective. However, the stage 3 trials are far more thorough.

 

[hexagonal]

I recommend starting with tirzepatide. From the stage 2 trials, it looks like reta will be safe and effective. However, the stage 3 trials are far more thorough.

They extended the reta stage 3 trials past the original end date - presumably to get more data on how much weight is actually lost - but they would have stopped the trials if they had encountered any significant health risks, no? Like we saw with azalaprag?

 

[zpped]

They extended the reta stage 3 trials past the original end date - presumably to get more data on how much weight is actually lost - but they would have stopped the trials if they had encountered any significant health risks, no? Like we saw with azalaprag?

Correct. The stage 3 trials have been a huge success. They transitioned everyone from the placebo onto reta already.

 

[Nmc110662]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

Tirzepatide

 

[LetsMakeMayhem]

I’d look at it the same way I’d look at dosage increases. Start with what’s considered the weakest or lightest, and go from there.

Well, ironically enough I was lucky to catch 30mg Tirz on presale, so I went with that. I imagine it will last me a WHILE.

 

[beefsteak]

I'd start with reta and then tirz for maintenance once I reach goal weight.

Currently 7 months into tirz, 7mg, and starting reta soon. Losing about 6-8lb/month. I feel like transition to reta is going to be a pain in the ass.

 

[dogmom]

reta

 

[keangkong]

They extended the reta stage 3 trials past the original end date - presumably to get more data on how much weight is actually lost - but they would have stopped the trials if they had encountered any significant health risks, no? Like we saw with azalaprag?

I agree that Eli Lilly extending the trials suggests good results in the stage 3 trials so far. Still we are talking about studies that have not yet completed.

 

[m100568]

**Not Asking for Medical Advice**
**Asking for personal perspectives only**

Hi All,
For those that have been on the weight loss journey with GLP-1s, if you had to start over all over again would you go with Triz or Reta as your first GLP?

Personally, I am thinking about starting Triz first and then moving on to Reta at a later time. Someone told me to "keep my options open" in case my progress stalls on one peptide so that I have still have other options. I know each of our bodies are different and we may not have the same experience on the same peptides, but just trying to figure out a great starting point.

Additionally, how you do feel about me stacking Amino 5 1 MQ while starting my first GLP? This was some information that was told to me by multiple people (as to avoid losing muscle mass, though I am exercising and doing cardio already).

Keep in mind, I've been a fata*s my whole life, even as a child. My metabolism is just garbage and needs some help. I've lost over 60lbs+ on diet changes and cardio alone, but I haven't been able to get the rest of this off. Thanks in advance for your insight

Just my personal opinion. . . Reta at low doses doesn't have as good appetite suppression. But, I love the active fat burning. I would, and have, stacked Tirz and Reta. Reports are that when you hit 6mg of Reta and above the appetite suppression kicks in and you can transition fully to Reta. I took a different route that worked for me, but I'm just experimenting. I went all the way up to 15mg on Tirz and slowly titrated up to 5mg on Reta. The appetite suppression was so strong I could only stand it for 2 weeks. I then started titrating down on Tirz and up on Reta. I'm currently at 12mg Reta and 4mg Tirz. Honestly, I think I could stop the Tirz, but I have so much of it that I am continuing to use it in small amounts. I may drop the Tirz to 2mg in the near future if the Reta continues to give me strong appetite suppression. By the way, the only real side effects I had was when I went from 5mg Tirz to 7.5mg Tirz (massive fatigue for 2 days), and when I jumped from 1mg Reta to 3mg Reta (diarrhea for a week).

 

[FlowerFairy]

Just my personal opinion. . . Reta at low doses doesn't have as good appetite suppression. But, I love the active fat burning. I would, and have, stacked Tirz and Reta. Reports are that when you hit 6mg of Reta and above the appetite suppression kicks in and you can transition fully to Reta. I took a different route that worked for me, but I'm just experimenting. I went all the way up to 15mg on Tirz and slowly titrated up to 5mg on Reta. The appetite suppression was so strong I could only stand it for 2 weeks. I then started titrating down on Tirz and up on Reta. I'm currently at 12mg Reta and 4mg Tirz. Honestly, I think I could stop the Tirz, but I have so much of it that I am continuing to use it in small amounts. I may drop the Tirz to 2mg in the near future if the Reta continues to give me strong appetite suppression. By the way, the only real side effects I had was when I went from 5mg Tirz to 7.5mg Tirz (massive fatigue for 2 days), and when I jumped from 1mg Reta to 3mg Reta (diarrhea for a week).

I’m only at 6 mg Reta and I have no food noise. I was stacking Tirz and Reta to start- 2reta w/4 Tirz- transitioned to Reta 4, then 6 when I ran out of Tirz. But I’m one person.