lewybodyfighter
I Just Joined!
Hello,
I am here to learn, but also on behalf of my mother, who has expressed interest in starting therapy with a GLP-1 agonist for weight loss and would like to know more, with the slight hope that the neuroprotective benefits that have been demonstrated in vitro, but also in humans correlatively, might translate to benefits to her. While there is no causal effect established, since she wants to use a GLP-1 agonist for medically-indicated weight loss anyway, I think it is reasonable to have some guarded hope that it may somewhat delay the progression of her Lewy body dementia, which is in an early stage.
My mother is still generally lucid and capable of making decisions. However, fluctuating cognition is a major feature of Lewy body dementia, so this is not always the case. It is important to me that she is always a part of the decision making process and I understand her wishes when she is fully cognitive.
I have a giant list of pharmaceutical drugs listed from those that are most correlated with an increased risk of Lewy body dementia and those that are most correlated with a lower risk, and everything in-between.
One of the drugs most correlated with a reduced risk of developing Lewy body dementia is exenatide, with an odds ratio (OR) of 0.56 [0.51-0.62]. This is a very strong correlation, and while it is not possible to draw causation from this information, drugs with very strong reduced odds ratio are the best I and my mother believe we can do right now.
Why exenatide? It cross the blood-brain-barrier (BBB) very well. Liraglutide also crosses the BBB somewhat, but is not associated with nearly as much benefit. Interestingly, semaglutide, which does not cross the BBB well, is associated with reduced risk of several dementias in some studies.
Unfortunately, I cannot find exenatide. I am in Canada, and it seems to have been discontinued here by the manufacturer, including all generics. I will discuss further with my mother, but it's looking like she wants to trial semaglutide.
If anyone is interested, I will keep this post updated with how things go with her GP, and if she starts therapy, if there are any cognitive benefits or noticable slowing of the disease process.
Thank you for reading,
lewybodyfighter
I am here to learn, but also on behalf of my mother, who has expressed interest in starting therapy with a GLP-1 agonist for weight loss and would like to know more, with the slight hope that the neuroprotective benefits that have been demonstrated in vitro, but also in humans correlatively, might translate to benefits to her. While there is no causal effect established, since she wants to use a GLP-1 agonist for medically-indicated weight loss anyway, I think it is reasonable to have some guarded hope that it may somewhat delay the progression of her Lewy body dementia, which is in an early stage.
My mother is still generally lucid and capable of making decisions. However, fluctuating cognition is a major feature of Lewy body dementia, so this is not always the case. It is important to me that she is always a part of the decision making process and I understand her wishes when she is fully cognitive.
I have a giant list of pharmaceutical drugs listed from those that are most correlated with an increased risk of Lewy body dementia and those that are most correlated with a lower risk, and everything in-between.
One of the drugs most correlated with a reduced risk of developing Lewy body dementia is exenatide, with an odds ratio (OR) of 0.56 [0.51-0.62]. This is a very strong correlation, and while it is not possible to draw causation from this information, drugs with very strong reduced odds ratio are the best I and my mother believe we can do right now.
Why exenatide? It cross the blood-brain-barrier (BBB) very well. Liraglutide also crosses the BBB somewhat, but is not associated with nearly as much benefit. Interestingly, semaglutide, which does not cross the BBB well, is associated with reduced risk of several dementias in some studies.
Unfortunately, I cannot find exenatide. I am in Canada, and it seems to have been discontinued here by the manufacturer, including all generics. I will discuss further with my mother, but it's looking like she wants to trial semaglutide.
If anyone is interested, I will keep this post updated with how things go with her GP, and if she starts therapy, if there are any cognitive benefits or noticable slowing of the disease process.
Thank you for reading,
lewybodyfighter
