Red40
GLP-1 Novice
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So I’m just curious, I’m on Reta & think I also want to start Tirz. Is anyone stacking them together, if so what’s your weekly schedule look like?
Is anyone doing a Reta + Tirz?
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GLP-1 Novice
Killswitch97
GLP-1 Novice
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I want to know the same. Reta doesn’t stop much food noise for me
VVoices
Recently Joined
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Why stack a peptide that targets receptors: GLP-1 + GIP + Glucagon with another peptide that targets the GLP-1 + GIP receptors? 🤔
Sounds like a great way to increase side-effects, just increase your reta.
Sounds like a great way to increase side-effects, just increase your reta.
CNCCurrency
GLP-1 Specialist
Killswitch97
GLP-1 Novice
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How much of each?reta every 3 days, on the 6th day I add tirz with the reta
RubbaDubba1
GLP-1 Enthusiast
Who isn't??? I'm off the sauce right now, as I have surgery next week. But I've stacked it when I was losing weight and on maintenance. I just did about a 1mg of each on maintenance and felt, like I got something from each one. Easy to maintain my weight, didn't crave much at all and I did each shot 72 hours apart.
CNCCurrency
GLP-1 Specialist
I have been on it over six months. Reta 8 mg split in 2 doses and 6 mg tirz on the 6th day
ThatNextGril
GLP-1 Enthusiast
Monday is reta 5mg, and Thurs is Tirz 8mg. I'll switch that up again at the end of the month.
jjplantgeek
GLP-1 Novice
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I started Tirz in October, titrating over time to 7.5mg. During the Black Friday promotions I bought a 60mg kit of Reta, but hadn't done anything with it at the time. In late January I decided to finally resconstitute a vial with the plan to slowly titrate up the Reta and down the Tirz. So far I have only titrated down to 6mg of Tirz, and have been at 6mg or Reta for several weeks. I feel this is a sweet spot, my fat continues to melt off and my muscle is maintaining (DEXA verified). I'll probably finish this 60mg vial and reevaluate, I may honestly be close to maintenance by that time.
lessthanhalf
GLP-1 Specialist
I am on 15.75mg of tirz plus 5mg of reta. Was still a bit hungry on 15mg of tirz but had very few side effects, so rather than switch and risk messing that up, added a bit of reta which helped. Trying to maintain 54% weight loss.
I don't see a lot of point in being on both unless you are at maximum doses of one, and even then you might be better just on a higher dose of the one you are on. The higher gip agonism of tirz might have advantages to counteract nausea from reta. If side effects are not an issue higher doses probably make more sense or adding in cagri.
I don't see a lot of point in being on both unless you are at maximum doses of one, and even then you might be better just on a higher dose of the one you are on. The higher gip agonism of tirz might have advantages to counteract nausea from reta. If side effects are not an issue higher doses probably make more sense or adding in cagri.
Gr33dyOctopus
GLP-1 Enthusiast
I also stack, recently have titrated down, cause I picked it back up after a 3 week hiatus and Hoooboy I couldnt eat for awhile. Im 95+ pounds down and haven't actually been hungry in months, I want food but not hungry for it.
Stacking 6mg tirz and 5 reta, 3 days apart and thats enough the pounds are just melting off, and I can still get fruit veggies and some protein in.
Stacking 6mg tirz and 5 reta, 3 days apart and thats enough the pounds are just melting off, and I can still get fruit veggies and some protein in.
lessthanhalf
GLP-1 Specialist
I can understand mixing a bit of both in people who have been on them separately to try to balance out hunger suppression and side effects. They are similar but not identical, but it is going to take a fair while to get a feel for the different effects, and probably impossible to work out if you take them both together without taking them separately first. It seems really common to mix low doses of reta and tirz and I always found it hard to work out why people would do that.
Still confused about everyone saying reta causes less appetite suppression than tirz, the effects of increased metabolic rate from reta do not seem to be high enough to explain more weight loss if people were actually eating more.
Still confused about everyone saying reta causes less appetite suppression than tirz, the effects of increased metabolic rate from reta do not seem to be high enough to explain more weight loss if people were actually eating more.
brah389
GLP-1 Apprentice
How long do you think you'll be off for surgery? I've been searching this topic as there isn't any real solid conversations on it and my surgeon said he would love to prescribe me monjourno but he won't because there isnt data on how this will effect soft tissue/bone growth. Any insight is appreciated!
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Griffwisha
GLP-1 Novice
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Me! I was doing Reta 2mg on day one, then Tirz 2mg on day 4. Reta makes me eat so much and increased my cravings for sweets. I now do Reta 2mg and maybe every other week a little Tirz for appetite suppressant and inflammation control. I tried Cag, but it didn’t work for me.
lessthanhalf
GLP-1 Specialist
There are a large number of studies being done investigating the effects of GLP medication use before surgery and their effects on post operative complications and healing. Results are not always positive but in general post operative complications are less likely overall, sometimes to quite a significant degree. Would need to know what sort of surgery to look it up or just go to google scholar and look up glp-1 and the procedure or just surgery.
brah389
GLP-1 Apprentice
Thanks less than half. You hit the nail on the head about specifics. I did find some results on GLP-1's. Shoot, my wife's doctor suspend her Ozempic 2 weeks prior and 2 weeks after her surgery but that was for a gall bladder and she takes it for diabetes. I suffered a compound fracture in my right leg just above the ankle. Tibia shattered and pooped 4 inches out of me leg, fibula snapped and I sheared my tibial nerve. I was 6'7" and 275lbs and lived in the gym 5-6 days a week and swam, stair climbed often. This happened in June 2025 and was non weight bearing for 16 weeks. Im now 340 lbs and had another surgery yesterday to install a larger bolt in my leg and bone graft for a non-union and non-weight bearing again for 8-12 weeks. But, I do have access to scholary articles through a university that you suggested. Im motivated to get in there and find out so I can get in there and get this weight off but not stop the healing process. I appreciate you! Attached photos from first surgery...when I do things, I do them big!
Attachments
Was on Tirz 15mg, now on reta 1mg every three days. Want to add Tirz back in, because so far, no positive or negative effects on Reta alone, except eating a whole bag of chips in the days between pins.😣
RubbaDubba1
GLP-1 Enthusiast
Suuuuure gotta call me out, jk. This is my 3rd surgery since being on a GLP-1, I wish I had a fancy MD type degree answer for you. But we all know in general what a GLP-1 does to us, to help us lose weight, control sugars and what it can potentially do for some of the good side effects. I could be out of commission for 3 weeks to 3 months, They need to fix a few things in my shoulder and then I get to turn around and do the other one which is even worse. YAY!
I think (therefore I don't know) your Surgeons concern would be, lack of protein, calcium, etc vitals nutrients that your body might lack if your on a GLP-1. There are people on GLP-1's getting F'n scurvy because of a lack of Vitamin C. Since you would most likely be eating a lot less and if there isn't a sufficient change in your diet and or supplementation along with taking a GLP-1. This is what I venture, they're worried about for soft tissue and bone growth. There may not be appreciable data, for some time on something like this in particular. I imagine, the same worries would be if they started to put teenagers on something like this, before they are full grown as well.
If you had to make an argument, to your surgeon to get the Tirz. I would do some researching on well documented, peer reviewed "current" research about the Tirz. That hopefully implies more benefits, to being on it vs off of it in your situation and that Surgeons particular field, if it exists. Present a plan of action or layout how you personally plan to avoid any shortcomings of this happening, if not come out that much better for it. Don't lie, but mention diet, exercise, supplementation, trainer, nutritionist to get'em on board. What it does for inflammation, help to keep the weight off, anything you can do to put another trainer in your corner for the fight. You generally don't get much time for appointments nowadays, if you think it may take a hot minute. You can schedule a long appointment, to give you a few more minutes, just going to cost you more $$$. Good luck Champ!
My ENT and my neurosurgeon had me stop my Reta 2 weeks before surgery and not to restart for at least 2 weeks after the surgery. Didn't need it however as was on a very restrictive diet in hospital and lost 8lbs in the week I was in the ICU. It was hell however as was also on a severe fluid restricted diet ( think 4oz oral fluid/day !). Even after going home had fluid restriction of 8oz (including water in foods such as fruit) for 2 weeks. Learned that a cup of grapes has 2 oz of fluid. not fun but did loose more weight
brah389
GLP-1 Apprentice
I appreciate the kind words rubbadubba but you made from very strong points. I dont mind waiting a little bit but not another 3-4 months along with the last 8 months since my accident of not starting weight loss. I wish you luck on your shoulders, ive had labrum tears reapirs in both of mine and its no walk in the park. And thanks for giving it straight, need more of that! Good luck!
lessthanhalf
GLP-1 Specialist
I just had another quick look at some of the studies, and there are a lot and they are still pretty contradictory. There is one study showing higher rates of non union after surgery to fix lower leg fractures in people taking GLP's, a surprisingly good fit for your problem, so I guess that is good enough to justify not taking them around and after the fracture until it has started healing up. But several large studies show significantly reduced rates of complications and later readmissions after elective surgeries like knee replacements, and especially hernia repairs. And there are many studies showing better outcomes in diabetics on GLP's for many different surgeries. And people are less likely to get addicted to painkillers after bariatric surgery and probably every other type of surgery if on GLP's.
It definitely sounds like the sort of thing you would need to listen to the surgeon's opinion on, even if they are not up with the latest research it is generally better not to annoy your surgeon.
The fracture sounds totally gruesome with the bone sticking out 4 inches!. Definitely a thank god for modern medicine problem to have, even if it is taking a while to get sorted out.
woundcarping
GLP-1 Specialist
You went from 15mg of Tirz to ~2mg of Reta…. Have you considered upping your Reta dose? It makes no sense going from a “max” dose to less than a “starting” dose and having any expectations of efficacy.
lessthanhalf
GLP-1 Specialist
In response to the above post and attcbf
You should be able to go straight to at least 5 or 6 mg of reta from 15mg of tirz, and that is being very careful. There are no guidelines anywhere for swapping from tirz to reta but 15mg of tirz is probably about equivalent to 8 to 10mg of reta in terms of gastrointestinal side effects, which is the most common issue.
If you have already lost a decent amount of weight you are going to be super hungry after stopping 15mg of tirz and going to a tiny dose of reta.
Assuming you do not have heart disease or diabetes you should be able to just use 6mg of reta and see if you get side effects, you would have to be very unlucky to get worse side effects than you got from 15mg of tirz, but it is not impossible.
If you are patient then doing it very slowly and carefully is the safest way and the way to get least side effects, but if you are worried about binging and putting on 10kg in a few weeks, then go straight to 6mg , if no side effects add an extra 2mg after 2 or 3 days , if still no side effects, do that again and you are up to 10mg in a week with fairly low risk of unexpected and prolonged side effects. You might need to stay on twice a week doses and give your body time once you get to 10mg but if you are ok with that dose you can gradually shift it back to once a week. I am only suggesting this option as you already tolerated 15mg of tirz ok. Doing this if you have never taken GLP's before could be extremely unpleasant. And this assumes you did not have lots of side effects on 15mg of tirz.
The weekly dose is just the sum of the doses over a week, just make sure that adds up to less than 10 or 12mg.
If you want to be more careful just go to 6mg and bump it up to 8mg after 2-4 weeks, and the same after that, till you get to 12mg , it really just depends on side effects, if you have none , then small dose increases are very unlikely to be a problem.
The only side effects that are more likely with reta than tirz are increased heart rate and skin sensory symptoms
You should be able to go straight to at least 5 or 6 mg of reta from 15mg of tirz, and that is being very careful. There are no guidelines anywhere for swapping from tirz to reta but 15mg of tirz is probably about equivalent to 8 to 10mg of reta in terms of gastrointestinal side effects, which is the most common issue.
If you have already lost a decent amount of weight you are going to be super hungry after stopping 15mg of tirz and going to a tiny dose of reta.
Assuming you do not have heart disease or diabetes you should be able to just use 6mg of reta and see if you get side effects, you would have to be very unlucky to get worse side effects than you got from 15mg of tirz, but it is not impossible.
If you are patient then doing it very slowly and carefully is the safest way and the way to get least side effects, but if you are worried about binging and putting on 10kg in a few weeks, then go straight to 6mg , if no side effects add an extra 2mg after 2 or 3 days , if still no side effects, do that again and you are up to 10mg in a week with fairly low risk of unexpected and prolonged side effects. You might need to stay on twice a week doses and give your body time once you get to 10mg but if you are ok with that dose you can gradually shift it back to once a week. I am only suggesting this option as you already tolerated 15mg of tirz ok. Doing this if you have never taken GLP's before could be extremely unpleasant. And this assumes you did not have lots of side effects on 15mg of tirz.
The weekly dose is just the sum of the doses over a week, just make sure that adds up to less than 10 or 12mg.
If you want to be more careful just go to 6mg and bump it up to 8mg after 2-4 weeks, and the same after that, till you get to 12mg , it really just depends on side effects, if you have none , then small dose increases are very unlikely to be a problem.
The only side effects that are more likely with reta than tirz are increased heart rate and skin sensory symptoms
woundcarping
GLP-1 Specialist
You can also frequently (ie daily) dose smaller increments as you work up so if there’s adverse sides you don’t have to wait as long for the overage to clear. I took 7mg my first week going that route. That was two months ago, taking 8-10mg/week now, split dosing, no adverse sides along the way.
Thank you lessthanhalf for the very thoughtful response. I lost 80 lbs with Tirz (zepbound) in about a year. Absolutely no side effects on the Tirz. But my insurance decided that I was now good to go, BMI under 30, and denied my doctor's reauthorization request (the evils of insurance companies is for another day). Spouse started micro-dosing Reta, and I thought with the little that we have, I should at least try it until our order comes in. [That was probably TMI, but figure I am a newbie and providing a better intro is not a bad idea.]
I ordered both Reta and Tirz and am not sure if I should do each, every other day, or just stick with a larger dose of Reta. Your post and woundcarping's have given me much to think about.
actually closer to 3mg/wk over a 2 week span (side rant, it would a whole lot easier to calculate dosing if the number of days in a week wasn't a prime number). But I understand your point. And, so far have only seen an increase in carb eating at that dose. Unfortunately, I am waiting for an order to be delivered, so cannot increase at the moment.
JuneBug1956
GLP-1 Apprentice
If you are on Peppy’s or Discord you could ask this question on Roundtable. I think it probably hasn’t been studied very well but the big concern might be loss of appetite, weight loss ( your goal) and poorer nutrition. That can affect bone healing. Possibly if you worked along side a nutritionist might mitigate the nutritional loss. I suspect it hasn’t been robustly studied on healing fractures.
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