Is titrating up too fast unsafe?

Builderman

Builderman

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What are the risks of titrating up too fast on reta? I’m a big guy with super severe craving. My first week I pinned 1mg. Second week I did 2mg. Aside from one day feeling more full than normal, I have not had any real effects - good or bad.

What risks am I running if I were too inject 3mg for my third shot? Am I being too impatient and just need to give the drug time to work?
 
I’m sure others more qualified will weigh in - but I see risk of the side effects hitting harder. Fatigue, nausea some stomach cramping even with bowel motility.
Personally started slow at 0.5 - then 1 for a couple weeks, split over 2 doses. Must have taken 8 weeks to get up to 3mg weekly total. I never had any side effects but wasn’t in a rush.
Choice to split was to avoid or mitigate chance of side effects and take it slower. Worked for me and still does do I’ve kept at this.
 
Fwiw, I've had a telehealth "weight loss coach" for Tirz suggest taking an intro dose for 4 weeks, tracking your weight, and if no results in that time, move up to the next dosing size. Continue that process until you see results, and only move up the dose when progress stalls for two weeks straight.

I'm sure others have different methods, but that has worked well for me (and can't see why it would be different for reta)
 
woundcarping said:
Starting out below trial dosing with your description is the definition of retarded.

If you have no GLP experience I’d use some caution.


Frequent small doses are better than weekly big bumps you have to ride out for longer.
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What do you mean starting below trial dosing? From my understand trials started at either 1mg or 2mg. Which is where I am.
 
Don't worry about the carp. If I was to get some mystery shit in the mail, that was supposed to be X (in your case reta). 1mg in .5ml bac, would be(and was) my initial/trial jab. If it didn't fuck me up in three or four days, I'd continue but on a plan. See/search reta trials, as mentioned above.
 
I bumped up too fast and had a week of barely going to the bathroom. Was very touchy and nervous situation. Because what i read said over 3 days see a doctor. Went to the doc and doc said as long as your intestines are moving food and youre able to fart you should be fine. Meanwhile dudes on here not pooping for 10 days! Trying to pass a log the size of the burg khalifa. God help them. Tldr be careful broseph
 
You need to study a bit on the half life of Reta and the blood concentration of sequential dosing over time. The way you're doing the ramp up nearly guarantees you'll overshoot your particular tolerance and experience a bout of whatever side effects you're prone to. My advice would be to just follow the tried and true 4 weeks between dosage increases. But if you really want to rush it, the safer way is to shorten the duration between doses, using small bump up doses, not jump the dose every week.

Play around with the blood concentration app at glp1plotter.com to see what I'm talking about.
 
I'll be increasing until there are symptoms in the RS.

Week 1: 2mg
Week 2: 2mg
Week 3: 4mg
Week 4: 4mg

Planned
Week 5: 6mg
Week 6: 6mg
Week 7: 6mg
Week 8: 8mg
Week 9: 8mg
Week 10: 8mg
Week 11: 8mg
Week 12: 8mg
Week 13: 10mg
Week 14: 10mg
Week 15: 12mg & continue indefinitely

1781303849389.webp
 
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dolph said:
I'll be increasing until there are symptoms in the RS.

Week 1: 2mg
Week 2: 2mg
Week 3: 4mg
Week 4: 4mg

Planned
Week 5: 6mg
Week 6: 6mg
Week 7: 6mg
Week 8: 8mg
Week 9: 8mg
Week 10: 8mg
Week 11: 8mg
Week 12: 8mg
Week 13: 10mg
Week 14: 10mg
Week 15: 12mg & continue indefinitely
Click to expand...
I’ve read 12mg really isn’t event necessary. I’d be interested to hear your experience from 10mg and up once you hit those levels
 
Stay at 2mg for a month, then go up to 4 if you like.

I started at 1mg every 3 days, and after a month I went up to 2mg every 3 days (4.66mg per week).

I've been on this dose for about 7 weeks now and I actually just had to reduce my dose because I can barely eat.

Side effects were never a big problem. I started at 0.5mg and quickly "titrated" up to the starting dose over the span of 7 days.
 
dolph said:
I'll be increasing until there are symptoms in the RS.

Week 1: 2mg
Week 2: 2mg
Week 3: 4mg
Week 4: 4mg

Planned
Week 5: 6mg
Week 6: 6mg
Week 7: 6mg
Week 8: 8mg
Week 9: 8mg
Week 10: 8mg
Week 11: 8mg
Week 12: 8mg
Week 13: 10mg
Week 14: 10mg
Week 15: 12mg & continue indefinitely

View attachment 27283
Click to expand...
Reality is going to hit you like a train unless you're like 600lbs.
 
Builderman said:
What are the risks of titrating up too fast on reta? I’m a big guy with super severe craving. My first week I pinned 1mg. Second week I did 2mg. Aside from one day feeling more full than normal, I have not had any real effects - good or bad.

What risks am I running if I were too inject 3mg for my third shot? Am I being too impatient and just need to give the drug time to work?
Click to expand...
If you're going to ramp more quickly, definitely "microdose" and use a 3day or longer schedule. Use a GLP1 blood level tracker to understand how much is in your system, but understand that the effects/"feelz" will take 24-72hr to peak. That means both appetite suppression (and glycogen metabolism) along with side effects like burping, HR increase, constipation, diarrhea, nausea, allodynia, anhedonia and sudden death will take time to appear. Don't take more until you know you're past your effects peak or you risk a hospital visit!

Personally other than the very first dose, I would never titrate faster than ~10% per dose, which is about the error in your knowledge of whats in the syringe anyway!

For example the fastest you might dose would be:
1 2mg
4 1mg
7 1.1mg
10 1.2mg
13 1.3mg
17 1.4mg
20 1.5mg
23 1.7mg
26 1.8mg
29 2mg ... 2.2...2.4...2.6...2.9...3.2...3.5...3.9...4.3...
Note that each week you're doing just about what the standard titration schedule is: 2 in the first week after 1st dose and 4mg starting the 5th week of titration. However, you're keeping your peak lower than standard while raising your minimum level faster. STOP and wait 3 extra days if you have ANY significant symptoms other than appetite suppression, or if you're unable to get >1000cal 20gr fiber and 80gr of protein on any day. Then go back no higher than the previous dose when symptoms subside. Keep your peak blood levels below that for at least another week or even 2. It's a marathon not a sprint (even if it is a bit of a race). If you're not feeling anything 6-9weeks (and 30mg) in, I'd start to wonder about what you actually have in the vial.
 
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dolph said:
I'll report back my findings. 6mg starts next Monday.
Click to expand...
Please tag me. I am very interested to see how long you can keep this going. You've heard of front loading, now get ready for backfilling!
 
It's not THAT different from the original trial data.

  • Weeks 1-4: 2 mg once weekly
  • Weeks 5-8: 4 mg once weekly
  • Weeks 9-12: 8 mg once weekly
  • Weeks 13 onward: 12 mg once weekly

I'll hit the 12mg ceiling 2 weeks later in week 15.
I'm hitting 4mg faster and adding 6mg to smooth the 8mg transition.
 
dolph said:
It's not THAT different from the original trial data.

  • Weeks 1-4: 2 mg once weekly
  • Weeks 5-8: 4 mg once weekly
  • Weeks 9-12: 8 mg once weekly
  • Weeks 13 onward: 12 mg once weekly

I'll hit the 12mg ceiling 2 weeks later in week 15.
I'm hitting 4mg faster and adding 6mg to smooth the 8mg transition.
Click to expand...
Will you keep going up even if you feel like you don't need to? I think the difference between trial data and reality is that we can find our own sweet spot
 
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