Just appetite suppression, or something more like with GLP-1s?

[jafarrr61020]

I have read that elora has more appetite suppression than our current big 3 (sema, tirz, reta) and I've been looking for explicit info about whether that's the only effect that leads to weight loss, or does it have other metabolism effects that also contribute, like glp-1s do?
I'm a tirz user who's had some success but side effects have kept me at medium doses despite averaging only 0.5 lb loss a week overall, lower now in month eight. I'm excited about elora particularly because of its HR reduction side effect, as my main tirz side effect is a big boost in HR that makes sleep and exercise tough. However, further appetite suppression isn't something I need, and I'm looking forward to learning more about elora's mechanism of action. Has anyone seen this addressed in the literature? I'd love a link, thank you!

 

[Scorpio73]

I have read that elora has more appetite suppression than our current big 3 (sema, tirz, reta) and I've been looking for explicit info about whether that's the only effect that leads to weight loss, or does it have other metabolism effects that also contribute, like glp-1s do?
I'm a tirz user who's had some success but side effects have kept me at medium doses despite averaging only 0.5 lb loss a week overall, lower now in month eight. I'm excited about elora particularly because of its HR reduction side effect, as my main tirz side effect is a big boost in HR that makes sleep and exercise tough. However, further appetite suppression isn't something I need, and I'm looking forward to learning more about elora's mechanism of action. Has anyone seen this addressed in the literature? I'd love a link, thank you!

Based on everything that's publicly available...hardly much so far, appetite suppression appears to be the primary driver of the weight loss. I haven't seen any published evidence that elora independently increases energy expenditure or has the broad metabolic effects we see with GLP-1 agonists.

The reductions in heart rate and blood pressure are definitely interesting, but those don't necessarily translate into increased metabolismin fact, they could suggest the opposite.

 

[jafarrr61020]

The reductions in heart rate and blood pressure are definitely interesting, but those don't necessarily translate into increased metabolismin fact, they could suggest the opposite.

I had the same thought, it's counterintuitive at best. It'll be interesting to see what develops; seems like we'll be hearing a LOT more about it since the incredible trial results