Let's talk GLP1's downfall - MUSCLE LOSS

[Eengineering]

Monoclonal antibodies are massively more difficult to produce than peptides or steroids.

It's not impossible - China produces plenty of monoclonal antibodies in general - but they're a lot more expensive and the production capacity is more limited in general. I wouldn't expect to see these in the grey market anytime soon

Would follistatin344 produce some of the same effects? From what I recall it is a myostatin inhibitor and I have seen it offered from some vendors.

 

[hexagonal]

Would follistatin344 produce some of the same effects? From what I recall it is a myostatin inhibitor and I have seen it offered from some vendors.

None of the current myostatin inhibitors work particularly well. Effect size is too small.

 

[keangkong]

One can certainly lose fat and build muscle but there are specific circumstances to doing that. Ones which I believe, from the way people are talking and the reason they're here, would apply to the majority of people here.

This somewhat of a deep dive into the topic but those special circumstances are covered in the first few minutes.

On the subject of resistance training. It's a must imo, not just for GLP1 users, for everyone who wants a long healthy life.

No need for special supplements, eat enough protein 0.6-1g/lb, 0.3g fat per lb, the rest carbs eaten before you train. Start with walking if that's where you are at, add bands, then body weight, then dumbbells or kettlebells, trian 1-2 reps to failure, push a set every so often to failure. Once you feel like you've made some progress then look at getting more serious about resistance training. There are so many various ways to train and implements one can use, it's almost limitless, don't sweat the details, just find what you enjoy and benefit from.

I'm not a bodybuilder by any means. But I am aware of Mike Isratael and know he knows what he's talking about. He's also funny.

 

[AndyPanda]

Trevogrumab and Garetsomab are in stage 2 human trials. Both drugs work by reducing the activity of myostatin and activin-a, both of which reduce and cap skeletal muscle growth. Thus, these new drugs UNCAP that growth.

At least in monkeys, when these two drugs were coupled with a GLP-1, there was massive fat loss coupled with muscle GROWTH, and this was despite a caloric deficit (and the fact that monkeys don't do resistance training). Might be available to the public by, say, 2027.

Anyone seen vendors carrying Trevogrumab yet?

 

[keangkong]

At least in monkeys, when these two drugs were coupled with a GLP-1, there was massive fat loss coupled with muscle GROWTH, and this was despite a caloric deficit (and the fact that monkeys don't do resistance training). Might be available to the public by, say, 2027. (Emphasis added.)

 

[hexagonal]

Anyone seen vendors carrying Trevogrumab yet?

Unlikely we'll see monoclonal antibody stuff with vendors anytime soon. China can produce them, but the facilities that can have enough legit work for pharma that they're not going to be funneling any to the grey or black market.

 

[indolent]

View attachment 8294

Thank you for the irrefutable documentary evidence that this outlandish claim is 1000% false.

Also, monkeys are funny.

 

[conzopiriani]

16 weeks.

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Oooo an ex of mine worked at genentech on protopin research in the 80s. I may have an old rollout promo t shirt laying around somewhere. Everyone knew it was the body builders who were going to be the most excited about it.

 

[Sandman1972]

I started lifting more than usual. High intensity and also some heavy lifts. Did that for 6 -8 months.
I liked the results but was tired- then I added Semorelin.
Wow. Huge difference. I do the troches bc I didn’t feel like injecting myself more than once a week.

 

[desinr-gal]

I bought Calcium HMB after seeing articles about how it has successfully prevented muscle loss in studies. Has anyone here tried it? I got a bag from bulk supplements, and have no clue how much or when to consume it. haha

 

[hexagonal]

I bought Calcium HMB after seeing articles about how it has successfully prevented muscle loss in studies. Has anyone here tried it? I got a bag from bulk supplements, and have no clue how much or when to consume it. haha

Usual dosing is about 3G a day. Some people recommend splitting doses or having it next to your workout, others think it's not particularly important.