Looking specifically for people who switched from high dose Tirz to high dose Reta

[Not_Your_Dad]

I'm a high dose Tirz veteran as well. For me, I tolerated Tirz well through 7.5mg; after that, I felt like I got hit by a train for the first three days after my Tirz pin. I couldn't eat or drink anything, and not in a good "oh my appetite is suppressed and I'm feeling good" way, but in a "well I haven't eaten or drank anything in 16 hours, surely this 8oz of water won't make me nauseous, but it somehow does" way. In stark contrast to my wife, who is on 15 mg Tirz and is doing phenomenally well.

Prior to Reta I added in CJC1295/Ipa twice daily, and Tesamorelin in the evening, to hopefully try and address some lingering visceral fat. These seem to increase my appetite, as expected, but it's generally not an issue.

When I started Reta, I went with a 2 mg pin 4 days after my Tirz pin. I just passed my 4th week on Reta, and have been titrating up quickly, 2 weeks with 2 mg, next 2 weeks with 4 mg, and this coming week I'll go to 6 mg. I've had no negative effects that I can see from the Reta, and I am so much more comfortable and happy on the lower dose of Tirz. I went from 12.5 mg down to 5 mg, and I'll be dropping to probably 2.5 mg for the next couple of weeks as I ramp Reta up.

My plan is to get on Reta exclusively and let the Tirz wash out over 5 or 6 weeks. I plan to be on Reta 10 mg by that point. If I'm dealing with any lingering hunger issues (my cycle with the GH secretagogues should be wrapped by then), I'll probably add Sema to the mix, based on the many positive experiences of people here with Sema and Reta.

In short, I have nothing negative to report by taking a more aggressive titration schedule with Reta while rapidly dropping the Tirz.

 

[Jeffreyml]

I started on Wegovy about 3-4 years ago when it was just coming out, started low and titrated up to max dose. I was Switched to TrIz (Mounjaro) once it came out since Wegovy wasn't working. Insurance stopped covering Triz so I was switched back over to Wegovy. After a year again of titrating down and back up, Triz was covered again and have been on it for about 2 years 15 mg No Changes, weight seemed to just hover and not drop. Switched to Reta on 11/27/25 and slowly titrated up while titrating down from 15mg Triz to 2.5 and Reta from 2 to 8mg. Over the past 4 years i followed the 7 day pin recommended with Triz medicine, switched to alternating pins now with a 5-6 day overlap and all of a sudden, weight has finally started to drop and food noise is gone. Barely can eat and have zero appetite. So as of today, I'm down 20lbs and averaging 3lbs per week. This sight has been huge helping with research, support and info. Also note that my Endo correctly diagnosed and found a 3.7cm tumor on my adrenal gland (Cushing's Disease) that was pushing excess cortisol into my body for 5-10 years. Had that removed about 2 years ago. This along with Reta have been a life changer for me. Nothing had worked prior,not Wegovy, Not Triz (Mounjaro), Only 8mg Reta and 2.5mg Triz is doing the job.

So happy i found this sight and all the information it provides.

Thanks