Loss of Life's Pleasures

senglish510

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I have been taking Reta for a few months. I am on 5mg. These past few weeks, I am finding that I don't want to do anything I normally like to do. I don't find joy in any of my hobbies, food (expected), sex, socialization, spending time with my family, or anything else. I never want to leave my house, or even my couch.

My husband took my kids out of town last weekend and I had the house to myself. I stayed in my bedroom until 5pm, doing nothing but looking on my phone. I originally thought that my depression was just bad right now, even though this feels a bit different. After reading about anhedonia on Reta, I think that is exactly what is going on.

For anyone who has experienced this, did Wellbutrin or Auvelity help with the Anhedonia? Did anything else help to relieve it? Did going down in your dose help? I am desperate for this feeling to go away. I really don't want to live this way, but I also don't want to be fat anymore. Please help!
 
Yes, I had very bad anhedonia when I got up to ~4.5mg Reta/week. Fairly common side effect of Reta from what I've read. Never improved but fortunately hit my target and got off - feel much better on Tirz at maintenance.

I'm also prone to dopamine mood issues so it was kindof a double whammy.
 
Yes, I had this badly with Tirz and Wellbutrin made a significant improvement. The weekend would roll around and I would try to think of something, anything, that I wanted to do and there was just nothing. I'd end up sitting on the couch most of the day because I couldn't figure out what to do. There were zero sparks for anything.

Restarted Wellbutrin and saw improvement within about 5 days. I'm back to having interests and desire to do stuff now.
 
It's pretty common on higher doses of Reta. From what I've seen, a lot of people start struggling with this once they get above 3–4 mg/week, although some experience it sooner and others later.

For me, it was honestly just part of the process. I've also heard that people on Tirz seem to have an easier time with these kinds of symptoms, but that's obviously anecdotal.

That said, there could be other factors contributing as well, such as not eating enough calories, not getting enough carbs, or even dehydration. It might be worth looking at those things before assuming it's entirely the medication, even if its a common case
 
After I started Reta, I got really heavy into peptide research. It has become a bit of obsession. I thought it was just another reason to stay on my phone and continue cellphone addiction. Although, there has been a death in the family, and a lot of depressing type tasks that needed to be done thereafter. I don't want to concede that it has given me anhedonia, but it probably has contributed.
 
I got that awful apathy when I was taking Reta 4mg. 5mg for one week made it intolerable. I got my hormones tested to discover Testosterone was also in the crapper. Dropped to Reta 2mg and added Te and feel like myself again! Every day is better. For what it’s worth, i don’t have weight to lose (125lbs) . I’m just trying to change body comp, At least now I have more energy to lift heavy things.
 
Im struggling with this right now. Im adding mots-c to see if it gives me a little bit more energy.
 
I had it with tirz. It fades off, then comes back up if I go up in dose, then fades off again. Adding a small stack of Survo helped a lot. I didn't have it with reta at all.
 
It definitely comes in waves. Not sure the phone scrolling helps, but I get it. Can you set one or two small goals for each day, the night before, so you have something, a little bit to work towards? I keep a running list, and I NEVER want to do any of them. This week is 2 pantry shelves a day. I MADE myself, so hard to do, get at it last night and lo and behold my mood lifted and I actually already got a good start to my morning, today. Good luck. The struggle is real.
 
sixgallery said:
Yes, I had this badly with Tirz and Wellbutrin made a significant improvement. The weekend would roll around and I would try to think of something, anything, that I wanted to do and there was just nothing. I'd end up sitting on the couch most of the day because I couldn't figure out what to do. There were zero sparks for anything.

Restarted Wellbutrin and saw improvement within about 5 days. I'm back to having interests and desire to do stuff now.
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Thank you! This gives me hope. I am on day 3 of Wellbutrin, so hopefully I will feel a little better soon.
 
SoCalGirl said:
It definitely comes in waves. Not sure the phone scrolling helps, but I get it. Can you set one or two small goals for each day, the night before, so you have something, a little bit to work towards? I keep a running list, and I NEVER want to do any of them. This week is 2 pantry shelves a day. I MADE myself, so hard to do, get at it last night and lo and behold my mood lifted and I actually already got a good start to my morning, today. Good luck. The struggle is real.
Click to expand...
This is good advice until I can figure out how to fix this problem. I think I will try to do this. I also probably need to force myself to go outside and take walks. Fresh air and sunshine will probably help. Thanks for the recommendation🙂
 
So many people have felt this. Crazy. Im on high doses of reta and tirz, mentally no real effects i can pinpoint. But physically hoo boy definitely go through GI garbage. Id rather have the ahedonia.
 
Gr33dyOctopus said:
So many people have felt this. Crazy. Im on high doses of reta and tirz, mentally no real effects i can pinpoint. But physically hoo boy definitely go through GI garbage. Id rather have the ahedonia.
Click to expand...

We need a power ranking of side effect on these things.

Like I'd take diarrhea over constipation all day every day lol (and at times it was all day every day!)
 
Spork said:
We need a power ranking of side effect on these things.

Like I'd take diarrhea over constipation all day every day lol (and at times it was all day every day!)
Click to expand...
You know I'm rhe opposite. I've been dealing with diarrhea for about a month on and off and I think I'd like to swap. I'd really prefer we have none of rhe side effects!
 
i'm feeling the anhedonia too, on 4mg/week
 
Hi,

Felt the same, after titrating to 4mg/week I got this weird disconnection feeling of not wanting to talk that much with close people.

But strangely, never got the GI issues a lot of users have brought up.

I guess when we reach this stage it's good to titrate down for a few weeks to see how you react, this is not a mathon. 🙂
 
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