ME/CFS: Did peptides help?

[SoreTodayStrongTomor]

Hi everyone,

I have ME/CFS with PEM and have been reading about mitochondrial problems and energy issues in ME/CFS.

I know these are not proven treatments, but I wanted to ask if anyone has tried:

• SS-31
• MOTS-c
• Thymosin alpha-1

Did any of them help with:

• PEM / crashes after activity?
• Better exercise tolerance or less crashing?
• Delayed PEM, not just everyday fatigue?

Did anyone have side effects or get worse?
Also, did these only help after treating things like POTS, dysautonomia, sleep problems, or MCAS?

I’m trying to understand real experiences and separate them from online hype.

Thanks.

 

[cujet]

I have a form of CF. But it's not the typical one 'ya read about online.
ME:
62M former athlete
Hashimoto's thyroid failure
Secondary Adrenal Insufficency (severe and life threatening)
Mixed Connective Tissue Disease (RNP antibodies, it's akin to Lupus)
Possible Myasthenia Gravis (muscles non responsive)
I don't have the classic pain symptoms of CFS. Nothing hurts.

NO, the bottom line is that SS31, MOTS-C, BPC157 TB5/400, GHK-Cu and Retatrutide have not helped my severe fatigue, exercise intolerance and subsequent week long crashes after energy expenditure. I've just experienced more than a month of fatigue so severe I can't keep my eyes open. I fall asleep constantly and wife wakes me up. Dog checks for signs of life. It's abject torture. So the peptides I've tried are no cure, no significant help with the fatigue and maybe it is time to try other peptides.

HOWEVER, Retatrutide has been a godsend in other ways. Epic weight loss, incredible inflammation reduction and stronger metabolism, which means I can eat without worry, and fuel my activities a bit better. The required starvation before my Reta use left me with insufficient calories to perform work.

SS31 and MOTS-C do not provide any feeling of relief for me. But again, there is a change there. When I walk the dog around the block I can if needed jog a very short distance home. Takes massive effort, but I've not been able to do that in years. Wiped out afterwards, but I can do it.

I continue to search for solutions. But my health remains in slow decline.

 

[BrightCandle]

ME/CFS and Long Covid sufferer.

Retatrutide so far has been of some relief, gives me a bit more energy. Can't speak to the others I haven't tried them yet.