Mitochondria Repair

[swimmer]

Next week I will be finishing a cycle of tesamorilin/ipmorelin which I am very happy with. My next journey might be to repair my mitochondria. I am in my early 60s so my guess is my mitochondria are in rough shape. I have a ton of questions about this subject. I am on high dose tirz (maintenance) and I am at my target weight. I work out every day. Swimming, hiking, weight lifting. I might be in the best shape I have every been. I have mots-c from sry, ss31 is on the way from Jeep. I recently learned I need to start nad+ first. I will order that soon. I also have 5‐amino 1mq if needed. My questions are:

how do I know my mitochondria need repair?
What can I expect when they are repaired or optomized?
Will my swim times improve?
Will I get stronger?
Do I need more than NAD+, SS31 and mots-c?
What should a cycle look like?

I would love to hear your thoughts and hear about your experiences.

 

[Rockybalboa]

I recomend that you visit https://youtube.com/@jaycampbell333?si=hX9A4Hpggn6bXIYA

He knows it all

 

[Mr. Blonde]

Jay Campbell is knowledgeable, but I always get the shady used car salesman vibes from him. Not saying that he would sell you the modern equivalent of a Flintstones car, its just the vibes I think he gives off.

But other than that, I listened to him in the last and learned at least a few positive things.

 

[SummerX]

Hey, I will be testing this protocol on myself for my mom once my SS-31 and NAD+ arrive:

 

[randompersonrandom]

I started this same protocol last week (the one @SummerX posted). Most of me thinks it's probably snake oil, and all I knew about mitochondria last week is that it's the powerhouse of the cell, but it just looks so magic and I'm bored. I'm only at the NAD part; I did 25mg the first time, then tried the 50mg the second time, seeing if I had any side-effects, and did not. Last night, I did the whole 100mg because I really should be supervised by an adult and am not. I swear to God I felt something on that one; wide-awake for the first time in weeks. I had a lovely three-mile walk. Prolly placebo and I'm going to quit screwing around and do the protocol as directed from here on out.

 

[tendency]

Next week I will be finishing a cycle of tesamorilin/ipmorelin which I am very happy with. My next journey might be to repair my mitochondria. I am in my early 60s so my guess is my mitochondria are in rough shape. I have a ton of questions about this subject. I am on high dose tirz (maintenance) and I am at my target weight. I work out every day. Swimming, hiking, weight lifting. I might be in the best shape I have every been. I have mots-c from sry, ss31 is on the way from Jeep. I recently learned I need to start nad+ first. I will order that soon. I also have 5‐amino 1mq if needed. My questions are:

how do I know my mitochondria need repair?
What can I expect when they are repaired or optomized?
Will my swim times improve?
Will I get stronger?
Do I need more than NAD+, SS31 and mots-c?
What should a cycle look like?

I would love to hear your thoughts and hear about your experiences.

Well, not sure where you are in the world or what your financial situation is like however you might be interested in booking an appointment at Dr. William Seeds' clinic in Beverly Hills: https://redoxmedicalgroup.com/ . In my book, you can't do much better than this doctor.

 

[Such1943]

I’m planning to run a modified version of the SS-31/MOTS-C/NAD+ cycle that was attached, using up the kits I have: SS-31 (10 mg), MOTS-C (10 mg), and NAD+ (500 mg). I’m a bit short on SS-31 and debating whether to grab another kit. I wish they offered 20 mg vials. I’ll be starting this early next year.

I’m 45 and could use the mitochondrial support. I definitely need an energy boost. TRT has helped with overall energy, but the Reta and calorie deficit effect it. Following this thread to hear from others who’ve run a similar cycle.

	SS-31 (3.57mg daily)	Mots-C (3.33mg/5mg M/W/F)	NAD+
Week 1			50​	25mg M/Thu
Week 2			50​	25mg M/Thu
Week 3			100​	50mg M/Thu
Week 4			100​	50mg M/Thu
Week 5	25​		200​	100m M/Thu
Week 6	25​		200​	100mg M/Thu
Week 7	25​		200​	100mg M/Thu
Week 8	25​	10​	200​	100mg M/Thu
Week 9		15​	300​	150mg M/Thu
Week 10		15​	300​	150mg M/Thu
Week 11		15​	300​	150mg M/Thu
Week 12		15​	300​	150mg M/Thu
Week 13		15​	300​	150mg M/Thu
Week 14		15​	400​	200mg M/Thu
Week 15			400​	200mg M/Thu
Week 16			400​	200mg M/Thu
Week 17			400​	200mg M/Thu
Week 18			400​	200mg M/Thu
Week 19			400​	200mg M/Thu

 

[yeddie]

A couple of weeks ago I decided to try out that protocol that SummerX posted. Went to order from Jeep and they were out of NAD+ and MOTS-C. Then I remembered that Mix was running a special on NAD+, but right on queue Ham posted that the stock in their US warehouse ran out. Ah well, I'll be able to get started eventually...

 

[miss-sanne]

Reta's glukagon part does stimulate new mitochondriae and boost performance.
I don't remember where I read it though. ;-)

 

[miss-sanne]

Next week I will be finishing a cycle of tesamorilin/ipmorelin which I am very happy with. My next journey might be to repair my mitochondria. I am in my early 60s so my guess is my mitochondria are in rough shape. I have a ton of questions about this subject. I am on high dose tirz (maintenance) and I am at my target weight. I work out every day. Swimming, hiking, weight lifting. I might be in the best shape I have every been. I have mots-c from sry, ss31 is on the way from Jeep. I recently learned I need to start nad+ first. I will order that soon. I also have 5‐amino 1mq if needed. My questions are:

how do I know my mitochondria need repair?
What can I expect when they are repaired or optomized?
Will my swim times improve?
Will I get stronger?
Do I need more than NAD+, SS31 and mots-c?
What should a cycle look like?

I would love to hear your thoughts and hear about your experiences.

AI found it for me :

• Mitochondrial biogenesis: Glucagon activates pathways like PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), which is a master regulator of new mitochondria.
• Higher energy turnover: More mitochondria = higher oxidative capacity = greater fat burning and thermogenesis.

 

[clayd]

Next week I will be finishing a cycle of tesamorilin/ipmorelin which I am very happy with. My next journey might be to repair my mitochondria. I am in my early 60s so my guess is my mitochondria are in rough shape. I have a ton of questions about this subject. I am on high dose tirz (maintenance) and I am at my target weight. I work out every day. Swimming, hiking, weight lifting. I might be in the best shape I have every been. I have mots-c from sry, ss31 is on the way from Jeep. I recently learned I need to start nad+ first. I will order that soon. I also have 5‐amino 1mq if needed. My questions are:

how do I know my mitochondria need repair?
What can I expect when they are repaired or optomized?
Will my swim times improve?
Will I get stronger?
Do I need more than NAD+, SS31 and mots-c?
What should a cycle look like?

I would love to hear your thoughts and hear about your experiences.

i did a bit of ss-31 and mots-c, i did feel a bit of a slight energy boost on mots. i take a nad precursor capsule daily. can't tell any difference.

i think the real answer here is to find a lab that will do a mitochondria function test. maybe do a before and after your course.

 

[Rockybalboa]

Jay Campbell is knowledgeable, but I always get the shady used car salesman vibes from him. Not saying that he would sell you the modern equivalent of a Flintstones car, its just the vibes I think he gives off.

But other than that, I listened to him in the last and learned at least a few positive things.

I listen to many others aswell becasue it’s like life in general. You need to collect information broadly and make your own conclusions.
whats boring is that no one on YouTube actually can leave any real useful information. If they do they suddenly disapapear from there.

 

[ZippityDooDah]

I recomend that you visit https://youtube.com/@jaycampbell333?si=hX9A4Hpggn6bXIYA

He knows it all

Well, not sure where you are in the world or what your financial situation is like however you might be interested in booking an appointment at Dr. William Seeds' clinic in Beverly Hills: https://redoxmedicalgroup.com/ . In my book, you can't do much better than this doctor.

 

[PopTart]

I’m a bit short on SS-31 and debating whether to grab another kit. I wish they offered 20 mg vials.

Another common size is 50mg. Uther has it in 30mg and 50mg.

 

[PopTart]

I am in my early 60s so my guess is my mitochondria are in rough shape.

I’m the same age as you. I’m on week 4 of the posted pdf. I did a cycle earlier this year. Mitochondria's depletes as we age so a cycle would likely benefit you, although, you may or may not experience any ‘feels’.

SS-31 provides a very noticeable increase in alertness for me. I don’t feel anything from NAD other than an initial ‘rush’ when dosing. I wasn’t in the gym when I ran the mots so I wasn’t able to check for increased exercise endurance that others have experienced.

Not everyone will illicit a physical response from each pep but that doesn’t mean they aren’t gaining a benefit. Older people tend to feel more than younger.

I plan to coordinate my mots dosing with my exercise schedule this time around to see if there’s a gain in performance.

 

[Mr. Blonde]

Haha, this thread is great. I was trying to give a diplomatic answer earlier. I like what I'm reading!

Also, Hunter Williams may be knowledgeable but ugh does he sound like a douche canoe.

 

[AndyPanda]

Anyone have faith in, or experience with NAD+ patches?

 

[Think]

Anyone have faith in, or experience with NAD+ patches?

They definitely work, but the effect is much weaker than parenteral administration

 

[tendency]

What makes you say this?

 

[hexagonal]

What makes you say this?

Minimal to no solid science behind their claims. We just have basically no studies supporting most of what they say this stuff does. We'll see mechanistic studies in animals held up as a reason (but look at how that turned out for AOD), some reported anecdotes, etc., but most of the effects they talk about are the sort of thing that is very placebo susceptible.

Meanwhile they have significant financial incentive to sell you on the idea this stuff does a lot. Books, affiliations with peptide companies and clinics, etc.

I'd take their claims with a grain of salt.

 

[tendency]

Minimal to no solid science behind their claims. We just have basically no studies supporting most of what they say this stuff does. We'll see mechanistic studies in animals held up as a reason (but look at how that turned out for AOD), some reported anecdotes, etc., but most of the effects they talk about are the sort of thing that is very placebo susceptible.

Meanwhile they have significant financial incentive to sell you on the idea this stuff does a lot. Books, affiliations with peptide companies and clinics, etc.

I'd take their claims with a grain of salt.

Yes, agree and this is all mostly accurate, IMO. However, none of this equates to Seeds being a quack.

He's got a very impressive clinical track record and certainly know the peptide field, far better I would hazard, than almost anyone on this site, lol.

Having said that, yes, I've found he misspeaks in his knowledge and sometimes will argue both sides of a subject and he certainly has his agenda - he is in Beverly Hills after all! But, there's also alot of gold in what he says as well. I would not simply dismiss his knowledge base as quackery. That's my .02 cents, anyhow.

 

[desinr-gal]

Minimal to no solid science behind their claims. We just have basically no studies supporting most of what they say this stuff does. We'll see mechanistic studies in animals held up as a reason (but look at how that turned out for AOD), some reported anecdotes, etc., but most of the effects they talk about are the sort of thing that is very placebo susceptible.

Meanwhile they have significant financial incentive to sell you on the idea this stuff does a lot. Books, affiliations with peptide companies and clinics, etc.

I'd take their claims with a grain of salt.

They have their own online shop of these same peptides and other things. They claim these are made in a US Factory!

 

[desinr-gal]

Now I did start out by following their cheat sheet, on my micro-dosing journey. But I had also watched numerous doctors also advocating this, and it has worked. I have been quite happy doing very low doses. But some of the things I have heard them say have caused concern. Hunter has done really clear videos painstakingly explaining things for people and I like that. But JC seems to be "off in the poppies" as my mom would say. And they have both said things that are disparaging toward those who arent physically fit. So that isnt cool.

 

[Nathanologist]

Jay Campbell’s a marketer with a DO, not a published researcher—lots of hype, little evidence. Dr. Seeds is a legit MD, but his peptide claims run faster than the science. Credentials don’t turn speculation into proof. In the end, it’s a choice: do you want your curiosity tickled, or do you want to stick with verifiable science? I don’t spend my money on whispers and wind, so I personally choose to follow the science best I can. I always start with “Who are they and how do they know what they claim to know?” Plenty of people profit off our hope and bias. If you start chasing “optimization” without a real problem, you’ll always find a predator ready to sell you one. Fear is always over priced.

There nothing wrong with admitting that your bored but curious (like @randompersonrandom kudos) but I always get a little cagey when the journey starts with uncertainty and FOMO. It’s like good’ol Abe Lincoln always told me, “You can’t trust everything you find on the internet.”

 

[Mr. Blonde]

Jay Campbell’s a marketer with a DO, not a published researcher—lots of hype, little evidence. Dr. Seeds is a legit MD, but his peptide claims run faster than the science. Credentials don’t turn speculation into proof. In the end, it’s a choice: do you want your curiosity tickled, or do you want to stick with verifiable science? I don’t spend my money on whispers and wind, so I personally choose to follow the science best I can. I always start with “Who are they and how do they know what they claim to know?” Plenty of people profit off our hope and bias. If you start chasing “optimization” without a real problem, you’ll always find a predator ready to sell you one. Fear is always over priced.

There nothing wrong with admitting that your bored but curious (like @randompersonrandom kudos) but I always get a little cagey when the journey starts with uncertainty and FOMO. It’s like good’ol Abe Lincoln always told me, “You can’t trust everything you find on the internet.”

Well said. I'm more of an Oscar Wilde man myself.

" I can resist anything except temptation "

 

[randompersonrandom]

There nothing wrong with admitting that your bored but curious (like @randompersonrandom kudos) but I always get a little cagey when the journey starts with uncertainty and FOMO.

oh yeah, make no mistake--I am in full blown midlife perimenopausal mid-life crisis freakout. It's low key and low stakes; I'm happily divorced, I never want for a lover or a friend (separately or in the same person), I have a rich, lovely life and nothing that is passing away is the sort of thing that would leave me with regrets. But I am definitely slightly out of my mind right now, walking around in my high school body, looking gorgeous AND older and trying to keep myself from feeling like those are mutually exclusive, grappling with what it means to me be a middle aged woman and living with the intensity of my emotions just turned WAY up.

It's got me slamming random peptides that promise to optimize my mitochondria. I don't actually really believe that's necessary, but it's certainly entertaining. I AM gonna stop after this, though, and go back to just Klow and Tirzepatide. And my tiny dose of Survo. And maybe epitalon. Shut up.