MK-0616 there’s a possibility that this may be available soon from china. It’s a pcks9 inhibitor. Science nerds please chime in.

[jg1979]

This peptide may be available soon! Does anyone know what the dosage would be? 40mg daily? Or less if pinning it? Any info would be much appreciated!

 

[FartfulCodger]

This would be really great. Let's hope it works!

From the phase 2b writeup: "Participants were assigned randomly (1:1:1:1:1 ratio) to MK-0616 (6, 12, 18, or 30 mg once daily) or matching placebo."

See https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018

 

[Jfrick11]

Does anyone know what the dosage would be? 40mg daily? Or less if pinning it?

It's a PCSK9 inhibitor and you wouldn't pin it. This is the oral version of the injectable that's already available. The injectable is crazy expensive, so this would be a huge win for both convenience and cost.
In phase 2 studies they tested these dosages: 6, 12, 18, or 30 mg once daily. All showed clinically meaningful reductions of LDL-C and ApoB w/ >55% placebo-adjusted reduction observed at doses of 12 mg and higher. MK-0616 was well tolerated and there were no overall trends in AEs across treatment groups
They're in phase 3 now, targeting a 20mg dose.