MOTS-C ISRs

gothpeacock

gothpeacock

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I love what MOTS does for my energy and strength during lifting. What I don’t love is the itchy lumps it often leaves for days. 😭 I’ve tried MOTS from 3 different vendors at this point: QSC, TCI and PGB.
Q mots was the worst - burned immediately after pinning and the longest persisting lumps. TCI was the mildest for me with ISRs. Recently got some PGB stock and while the effects are great I’m back to dealing with lumps under the skin. Considering offlloading the kits I got and going back to TCI. 😭 does anyone else struggle with the ISRs from this specific pep?
 
How much are you diluting it? I mix so that 5mg is 50 units. That gives me an 'acceptable' burn using MOTS-C from QSC. I tried concentrating it to 5mg in 20 units. That was not fun.
 
gothpeacock said:
I love what MOTS does for my energy and strength during lifting. What I don’t love is the itchy lumps it often leaves for days. 😭 I’ve tried MOTS from 3 different vendors at this point: QSC, TCI and PGB.
Q mots was the worst - burned immediately after pinning and the longest persisting lumps. TCI was the mildest for me with ISRs. Recently got some PGB stock and while the effects are great I’m back to dealing with lumps under the skin. Considering offlloading the kits I got and going back to TCI. 😭 does anyone else struggle with the ISRs from this specific pep?
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I have pgb mots from December and I took get lumps.
 
ktg123 said:
How much are you diluting it? I mix so that 5mg is 50 units. That gives me an 'acceptable' burn using MOTS-C from QSC. I tried concentrating it to 5mg in 20 units. That was not fun.
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You make a fine point, maybe I should dilute it more - currently I add 1ml to a 10mg vial which makes my 5mg doses 50 units…i don’t love the idea of making the injection more units but if it prevents the lumps…
 
Ssa motsc seems good. I mix 0.5ml into 10mg and take the whole thing. It itches but doesn't leave a bump
 
I only add .5ml BAC to Cain's and no ISR's, even injecting the entire 10mg vial into the glute. I did notice ISR's when pinning 5mg of PGB's into my thighs but only lasted about an hour or so. I may switch back to PGB next week to see if I notice a difference.
 
When I injected 1ml I had horrible ISR every single time. Next vial I decreased it so my dose was with 0.25ml - I did it very slowly and had no stinging or ISR.
 
Using PGB Mots-C, 2 ml for 10 mg, so 50 units for 2.5 mg dose. It burns and itches for an hour or two and then goes away but leaves a visible bump for a few days. Diluting it more might help.
 
I also add some air to syringe and flick it so the air bubble is next to the plunger. I read somewhere that the ISR might be from the last drop or two when you withdraw the needle.

I pin again tomorrow and will dig some PGB out of the freezer to see if I get a different reaction than the Nexaph. I will also check the PH to see if it might be the reason for so many people reporting ISR's.
 
GimmeABreak said:
I also add some air to syringe and flick it so the air bubble is next to the plunger. I read somewhere that the ISR might be from the last drop or two when you withdraw the needle.

I pin again tomorrow and will dig some PGB out of the freezer to see if I get a different reaction than the Nexaph. I will also check the PH to see if it might be the reason for so many people reporting ISR's.
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Ph should be where for the mots? I have strips
 
Nikki nik said:
Ph should be where for the mots? I have strips
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I'm not really sure, but if I had to guess 4-6.5 would make for a fairly comfortable pin.

I forgot to test the PH when I reconstituted this morning and I did get a mild ISR pinning 10mg in the glute. Not too bad though, just a little itchy and a small bump under the skin. I'm thinking it will be better by tomorrow.
 
I just ordered from Nexaph. What dosing regiment are you all following? I'm looking to add it to the Tirz I'm taking (50 units @ 10/1).

Any recommendations?
 
Are you looking for a Mots-C Protocol or asking about mixing in vial?

GLP1s are recommended to not mix:
Here is a chart on mixing I have seen many times.
1743369520811.png
 
Protocol, but I've read several folks stacking Mots with tirz. The chart shows no stacking with GLP1s. Why would that be?
 
Peloma said:
Protocol, but I've read several folks stacking Mots with tirz. The chart shows no stacking with GLP1s. Why would that be?
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The chart is for mixing, not stacking using separate vials.

Many people add Mots-C while on tirz, just not in same vial.

There are many protocols, a common one I found is as follows, I have always heard use Hospira BAC water for reconstituting:

MOTS-c Protocol (6 Weeks)​


  • Dose: 5mg per injection
  • Frequency: 3 times per week (e.g., Monday, Wednesday, Friday)
  • Duration: 6 weeks
  • Administration: Subcutaneous (SQ) injection

Tapering Off​


  • Week 7: Reduce to 5mg twice per week
  • Week 8: Reduce to 5mg once per week
  • Break: After tapering, take a 4-6 week break before starting another cycle

Additional Notes:​


  • It is often used for mitochondrial support, metabolic function, and endurance.
  • Can be stacked with other peptides like SS-31 or GLP-1s for added effects.
  • Always reconstitute with sterile water and store properly in the refrigerator.
Click to expand...
 
Skidude said:
The chart is for mixing, not stacking using separate vials.

Many people add Mots-C while on tirz, just not in same vial.

There are many protocols, a common one I found is as follows, I have always heard use Hospira BAC water for reconstituting:
Click to expand...
I see where what I wrote seemed confusing. I want to keep myself at 50 units of as long as possible. Figured Mots would be a good addition.
 
Peloma said:
I see where what I wrote seemed confusing. I want to keep myself at 50 units of as long as possible. Figured Mots would be a good addition.
Click to expand...
I noticed you had the formula for 5mg, just thought you listed it for mixing. heh..
No big deal, chart might be useful for others.

There are many complimenting "stacks", you might check this Telegram out a ton of good data:
Stairway to Gray Telegram Site
 
Peloma said:
So the burn is a thing, eh?
Click to expand...
For some, they seem to experience ISR burn, I personally never have. If any at all it would be temporary at best. I did mix 10mg/1ml so had 2 doses in each vial, some say adding more BAC helps, others are concerned with PH. I might just be lucky or oblivious, a little sting goes away quickly on the occasion I had any at all.
 
I just remembered I had some MOTS-C from Verified Peptides. 10mg vial + 1mL bac water, did 5 mg/.5mL.
It stung a lot less than the GHK-Cu GLOW I did 9 units of, which I split into 3 separate injection sites. That shit still SMARTS every time.
 
Skidude said:
For some, they seem to experience ISR burn, I personally never have. If any at all it would be temporary at best. I did mix 10mg/1ml so had 2 doses in each vial, some say adding more BAC helps, others are concerned with PH. I might just be lucky or oblivious, a little sting goes away quickly on the occasion I had any at all.
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Curious: did you pin both doses in a day, or space them out? Either way (and I know it has been disproven, but), did you notice a degradation in effects on shot 2 when taken later?
 
Peloma said:
Curious: did you pin both doses in a day, or space them out? Either way (and I know it has been disproven, but), did you notice a degradation in effects on shot 2 when taken later?
Click to expand...
the 10/1 I was referring to was just reconstitute mix, some might mix 1.5ml BAC.
I use simple math when reconstituting, if i want 1/3 total pep, i triple my desired BAC. in this case I want 1/2 pep so I doubled Bac. IE: 10MG vial = 2 doses no matter how much bac i add. 2 ml would be 1 ml per dose. 1 ml is .5ml per dose, and so on.

My protocol was 5mg 3x per week. I think the effect was more underlying than obvious, but I will be doing another cycle soon. I also did the SS-31 for first 30 days and took TMG.

My next protocol is likely going to be SS-31 morning, Mots evening.
Quantifying effects is challenging as there are many factors, not the least of which is the Tirz fatigue.
I do feel like there are benefits, and from what I have read, many that are just not feels.
 
Skidude said:
the 10/1 I was referring to was just reconstitute mix, some might mix 1.5ml BAC.
I use simple math when reconstituting, if i want 1/3 total pep, i triple my desired BAC. in this case I want 1/2 pep so I doubled Bac. IE: 10MG vial = 2 doses no matter how much bac i add. 2 ml would be 1 ml per dose. 1 ml is .5ml per dose, and so on.

My protocol was 5mg 3x per week. I think the effect was more underlying than obvious, but I will be doing another cycle soon. I also did the SS-31 for first 30 days and took TMG.

My next protocol is likely going to be SS-31 morning, Mots evening.
Quantifying effects is challenging as there are many factors, not the least of which is the Tirz fatigue.
I do feel like there are benefits, and from what I have read, many that are just not feels.
Click to expand...
Do you think I shouldn't go straight to Mots-c? On Tirz now. Should I start with ss, then move on to mots?
 
Last edited:
Peloma said:
Do you think I shouldn't go straight to Mots-c? On Tirz now.
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I am not sure I understand the question. I used these for other reasons than Tirz so these are stacks/etc.

This is what my girlfriend (AKA ChatGPT) has to say about this:

Using MOTS-C While Taking Tirzepatide​


MOTS-C and Tirzepatide (GLP-1/GIP receptor agonist) can be used together, but some factors should be considered:


Potential Benefits of Combining MOTS-C and Tirzepatide:​


✅ Enhanced Fat Loss – Tirzepatide improves insulin sensitivity and reduces appetite, while MOTS-C enhances mitochondrial function and fat oxidation.
✅ Improved Energy & Metabolism – MOTS-C helps with cellular energy production, which may counteract any fatigue from GLP-1 agonists.
✅ Muscle Preservation – Tirzepatide can sometimes lead to lean mass loss, but MOTS-C supports muscle health and endurance.


Considerations & Precautions:​


⚠️ Potential Increased Insulin Sensitivity – Both compounds improve insulin sensitivity, so blood sugar levels should be monitored to prevent hypoglycemia.
⚠️ Fatigue & Nausea Risk – GLP-1 drugs can cause nausea, while MOTS-C may briefly lead to fatigue. Start with lower doses if needed.
⚠️ Dosing Timing – Some prefer using MOTS-C on non-Tirzepatide injection days to avoid overwhelming the system.


Suggested Dosing Strategy:​


  • Tirzepatide: As prescribed (usually weekly).
  • MOTS-C: 5 mg 3x per week for 4-6 weeks, then taper or take a break.
Click to expand...
 
Skidude said:
I am not sure I understand the question. I used these for other reasons than Tirz so these are stacks/etc.

This is what my girlfriend (AKA ChatGPT) has to say about this:
Click to expand...
Should ss preceed mots, or does it matter? I'm stacking with tirz.
 
So is the mots-c 3 x a week more for strength during workouts? I don't work out, I just want to combat the Tirz fatigue. Would once or twice weekly do that?
 
hotdog! said:
So is the mots-c 3 x a week more for strength during workouts? I don't work out, I just want to combat the Tirz fatigue. Would once or twice weekly do that?
Click to expand...
I use my Mots C for normal work days! 2.5 for 5 days a week
 
hotdog! said:
So is the mots-c 3 x a week more for strength during workouts? I don't work out, I just want to combat the Tirz fatigue. Would once or twice weekly do that?
Click to expand...
I've never pinned 5mg at once but I am this weekend in hopes of hitting the gym
 
I am interested in overall energy support. Would MOTS be the best in your opinion?
 
gothpeacock said:
For me they’re painful lumps that wouldn’t really show up in a photograph. They’re very uncomfortable and itchy.
Click to expand...

Mine weren't painful.... just a knot under my skin. Wouldn't show up in a picture either.
 
Mle2520 said:
I am interested in overall energy support. Would MOTS be the best in your opinion?
Click to expand...
Still wondering myself which peptides lead the pack regarding energy (or if there is just so much variation you might as well just start with whatever is cheaper 🙂)
 
Peloma said:
I start Monday. I shall report research findings... standby.
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I absolutely love mots c. I was researching 10mg every other day for a month. O top of the the cjc and ipa and tirz, my rs felt like freaking superman. Only isr lasted for 20 minutes and it was slight redness and burn. Cycling off now and will resume either in June or july
 
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