My Cagri Chronicle: ongoing updates on progress with cag starting October 2024

I used 50% AA, 50% bac
Dude, are you sure you are doing it right? I thought I read elsewhere in these forums that the minute you add AA the vial must be pinned and what's left is garbage (it loses potency in matter of minutes or hours?). Can greater minds in here chime in as I have no clue myself on these matters and science wasn't my favorite subject at school anyway LOL.
 
Dude, are you sure you are doing it right? I thought I read elsewhere in these forums that the minute you add AA the vial must be pinned and what's left is garbage (it loses potency in matter of minutes or hours?). Can greater minds in here chime in as I have no clue myself on these matters and science wasn't my favorite subject at school anyway LOL.
Me bad. Sorry. Used AA@0.6% .
 
Me bad. Sorry. Used AA@0.6% .
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
I haven't heard this
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
 
ok but how about what other people are saying- That once you mix AA into the vial it should be used immediately or it goes bad, meaning if you constitute a 5mg cagri with AA and BAC water, and you use 1mg cagri, the rest is useless and can't be used since it goes bad within max an hour or so?
People are often wrong. And moreso in a somewhat controversial topic like Cagri.
 
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
Here part of the discussion from another forum: So basically at a ph of higher than 4 supposedly (i have no proof of it) fibrils can be formed, but if you lower the ph with AA then the risk of fibrils (again supposedly) goes away, but the reconstituted cagri needs to be used ASAP or it loses effectiveness. I personally ignored such concern as people were all over the place with some claiming that the risk were very low, so I've been just constituting with BAC and using it within about 10 days. But I was wondering anyway if such claims were valid or not...
Don't they speak to the different pH levels (4 and 7.5) while subjecting Cagri to mechanical stress?

And they couldn't form any fibrils? Are you saying that this is incorrect and they didn't use the right equipment to test for formation of harmful molecules?
Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones fibrillate. Fibrils are a lot easier to detect than oligomers.

Two important points about those tests:

1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency.
2. Many of the amylin analogues did *not* fibrillate at pH 4.0 (not just cagrilintide).
 
Here part of the discussion from another forum: So basically at a ph of higher than 4 supposedly (i have no proof of it) fibrils can be formed, but if you lower the ph with AA then the risk of fibrils (again supposedly) goes away, but the reconstituted cagri needs to be used ASAP or it loses effectiveness. I personally ignored such concern as people were all over the place with some claiming that the risk were very low, so I've been just constituting with BAC and using it within about 10 days. But I was wondering anyway if such claims were valid or not...

Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones fibrillate. Fibrils are a lot easier to detect than oligomers.

Two important points about those tests:

1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency.
2. Many of the amylin analogues did *not* fibrillate at pH 4.0 (not just cagrilintide).
Humm. I've been using mine for 4 weeks/vial. Say more?
 
Humm. I've been using mine for 4 weeks/vial. Say more?
Me too, with plain bac water.

I don't think Novo would be proceeding with a substance as fragile and/or dangerous as some Internet virtual scientists speculate. They are even doing a small 18 wk study with both Sema and Cagri in the same chamber which is scheduled to conclude in April ('25). This timing and small size of the study could be an indicator of confidence in a singular delivery of both peptides. Novo over projected expected results with investors regarding CagriSema yet the result is a formidable competitor for tirzepatide (until Reta hits).
 
Say more?
I honestly don't know anything about it other than what I've read on some other forums in these boards, but some were saying there is a remote possibility of cagri that has a greater than PH of 4 when constituted can be problematic (may form fibrils which are dangerous supposedly) and to lower its ph people recommended using AA. However, they were saying that if you use AA then the vial needs to be used very soon (hours not days) or it loses it potency completely. But then there were some others saying the risk of fibrils is so remote that they would not be worried about it. But the consensus seemed to be it is best to use within a shorter period of time lets say within 20 days. Because I had no side effects I've actually been using a relatively high dose (2mg on days 1, 8 and 15 cause I bought the 5mg bottles that were testing 6mg +) and finishing the vial withing 15 days of constituting it with BAC. I actually bought AA but never bothered to use it since everyone was saying it destroys the potency unless used immediately. I intend to keep using it this way.
 
Me too, with plain bac water.

I don't think Novo would be proceeding with a substance as fragile and/or dangerous as some Internet virtual scientists speculate. They are even doing a small 18 wk study with both Sema and Cagri in the same chamber which is scheduled to conclude in April ('25). This timing and small size of the study could be an indicator of confidence in a singular delivery of both peptides. Novo over projected expected results with investors regarding CagriSema yet the result is a formidable competitor for tirzepatide (until Reta hits).
They were saying that NOVO already fixes the PH at 4 and at that level is not dangerous. Again, I literally have no idea as I have not researched much but people were saying these things and I decided to err in the side of caution to not use it long after constituting it (I would not go over 30 days as an example, even though I've been using mine within 15).
 
I haven't heard this
It is all over in another forum on these boards on Cagri. Personally, I have zero knowledge other than what I read on these boards. Here:

 
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
Not according to what people were saying (Personally have no clue. as I have not researched the subject enough). Basically they were saying cagri ph should be about 4 or there is a risk of fibrils being created, and to lower the ph people recommended using AA. However, they said that once you introduce AA into the vial it is a case of "you use it, or lose it" within hours as the potency of it is degraded very fast. Personally, can't say either way as I have no knowledge other than what I read on those boards. As mentioned earlier I decided to use normal BAC but to not prolong too much using the vial (wouldn't go over 30 days, been using mine within 15)
 
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However, they said that once you introduce AA into the vial it is a case of "you use it, or lose it" within hours as the potency of it is degraded very fast. Personally, can't say either way as I have no knowledge other than what I read on those boards. As mentioned earlier I decided to use normal BAC but to not prolong too much using the vial (wouldn't go over 30 days, been using mine within 15)
Thanks for sharing what you know - I did a little searching and from what I can find a dilute AA will not degrade peptides within hours. Sounds like it takes a strong acid (or base) and high temps to be a problem. Having said that, I'm pretty lax with my cagri (not using AA at all, and rolling with a vial for a month while only visually checking to ensure it's still crystal clear) and should probably tighten things up so thank you for the reminder. I'm only using 0.2mg/wk and it's difficult to throw away the rest of the 5mg vial - I need a kit of Cagri 1. :giggle:
 
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
 
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
Alarmingly, I'm 100% with you. We ride at dawn... skinny and demented. Onward!
 
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
Sometimes I don't know whether it's a 😲 or 🤣!

🤷🏻‍♂️
 

Cagrilintide in stock on PGB get some before I buy it all!!!​

5mg kit for $115 isn't bad. cag pricing is all over the place man. I have supposedly bought a kit of 10mg for $70 but it's a different "vendor" and i'm cognizant that it's possibly i scam. i won't share details here for now until i find out one way or the other.

but in the meantime it seems like $115 for 5mg is pretty ok, and i guess it's tested already?
 

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