My Cagri Chronicle: ongoing updates on progress with cag starting October 2024

nonyabizznez said:
Me too, with plain bac water.

I don't think Novo would be proceeding with a substance as fragile and/or dangerous as some Internet virtual scientists speculate. They are even doing a small 18 wk study with both Sema and Cagri in the same chamber which is scheduled to conclude in April ('25). This timing and small size of the study could be an indicator of confidence in a singular delivery of both peptides. Novo over projected expected results with investors regarding CagriSema yet the result is a formidable competitor for tirzepatide (until Reta hits).
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They were saying that NOVO already fixes the PH at 4 and at that level is not dangerous. Again, I literally have no idea as I have not researched much but people were saying these things and I decided to err in the side of caution to not use it long after constituting it (I would not go over 30 days as an example, even though I've been using mine within 15).
 
clayd said:
I haven't heard this
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It is all over in another forum on these boards on Cagri. Personally, I have zero knowledge other than what I read on these boards. Here:

S

Thread 'In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)'

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)​

“A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort.”​

So begins Novo Nordisk’s excellent design study of cagrilintide.[1] In the very first sentence, the creators of cagrilintide lay out their challenge: formulating an amylin analog that doesn’t form amyloid fibrils.

Human amylin is a hormone that's released after eating along with insulin within the pancreas and helps regulate...
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scarywood75 said:
It's when you use pure BAC that it degrades faster (not that fast tho) because it's most stable in a acidic pH solution.
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Not according to what people were saying (Personally have no clue. as I have not researched the subject enough). Basically they were saying cagri ph should be about 4 or there is a risk of fibrils being created, and to lower the ph people recommended using AA. However, they said that once you introduce AA into the vial it is a case of "you use it, or lose it" within hours as the potency of it is degraded very fast. Personally, can't say either way as I have no knowledge other than what I read on those boards. As mentioned earlier I decided to use normal BAC but to not prolong too much using the vial (wouldn't go over 30 days, been using mine within 15)
 
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Fisherman2356 said:
However, they said that once you introduce AA into the vial it is a case of "you use it, or lose it" within hours as the potency of it is degraded very fast. Personally, can't say either way as I have no knowledge other than what I read on those boards. As mentioned earlier I decided to use normal BAC but to not prolong too much using the vial (wouldn't go over 30 days, been using mine within 15)
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Thanks for sharing what you know - I did a little searching and from what I can find a dilute AA will not degrade peptides within hours. Sounds like it takes a strong acid (or base) and high temps to be a problem. Having said that, I'm pretty lax with my cagri (not using AA at all, and rolling with a vial for a month while only visually checking to ensure it's still crystal clear) and should probably tighten things up so thank you for the reminder. I'm only using 0.2mg/wk and it's difficult to throw away the rest of the 5mg vial - I need a kit of Cagri 1. 😊
 
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
 
chmuse said:
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
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Alarmingly, I'm 100% with you. We ride at dawn... skinny and demented. Onward!
 
chmuse said:
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
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Sometimes I don't know whether it's a 😲 or 🤣!

🤷🏻‍♂️
 
Super Trips said:

Cagrilintide in stock on PGB get some before I buy it all!!!​

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5mg kit for $115 isn't bad. cag pricing is all over the place man. I have supposedly bought a kit of 10mg for $70 but it's a different "vendor" and i'm cognizant that it's possibly i scam. i won't share details here for now until i find out one way or the other.

but in the meantime it seems like $115 for 5mg is pretty ok, and i guess it's tested already?
 
clayd said:
5mg kit for $115 isn't bad. cag pricing is all over the place man. I have supposedly bought a kit of 10mg for $70 but it's a different "vendor" and i'm cognizant that it's possibly i scam. i won't share details here for now until i find out one way or the other.

but in the meantime it seems like $115 for 5mg is pretty ok, and i guess it's tested already?
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PGB is pretty good I bought 5 kits so I will PH test and human consume when i get them and post it.
 
clayd said:
5mg kit for $115 isn't bad. cag pricing is all over the place man. I have supposedly bought a kit of 10mg for $70 but it's a different "vendor" and i'm cognizant that it's possibly i scam. i won't share details here for now until i find out one way or the other.

but in the meantime it seems like $115 for 5mg is pretty ok, and i guess it's tested already?
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clayd said:
but trips, it says right on the pgb website said human use is strictly prohibited
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Never was good at following the rules LOL
 
clayd said:
5mg kit for $115 isn't bad. cag pricing is all over the place man. I have supposedly bought a kit of 10mg for $70 but it's a different "vendor" and i'm cognizant that it's possibly i scam. i won't share details here for now until i find out one way or the other.

but in the meantime it seems like $115 for 5mg is pretty ok, and i guess it's tested already?
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I don't think i ever seen cagri prices that low. Not even close.
 
Update: hit my February goal weight today with 10 days to spare! My March goal is another 5 pounds, and that is also my original final goal weight, but I will have to revise that down a bit. 41 days to drop 5 pounds, I can do that!

Adding cagri 1mg to tirz 15mg doesn't seem to give me as much feelz anymore so it might be time to increase the cag
 
clayd said:
Update: hit my February goal weight today with 10 days to spare! My March goal is another 5 pounds, and that is also my original final goal weight, but I will have to revise that down a bit. 41 days to drop 5 pounds, I can do that!

Adding cagri 1mg to tirz 15mg doesn't seem to give me as much feelz anymore so it might be time to increase the cag
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i'm at 1.5 -2mg every few days no problems still get a little tired here but worth the food noise reduction.
 
Doing the itty bitty .0415 dose every seven days, with a second dose same size day after. (Will try doing .8 so I can pin once a week w my next dose, but I was chicken about side effects. Probably more used to it now.) Zero side effects now. Honestly not feeling much different other than maybe less hungry a little? I'm not eating less. But I'm seeing the results on the scale. Current goal is increase cagri and not sema until I get to a 1:1 ratio like the clinical trial.
 
cldfront said:
I'm only using 0.2mg/wk
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This is insulting to cagri 😂. Do at least 1mg dude, 0.2mg is nothing. I started (accidentally) with 4mg and never done less than 2mg at once lol. I'm surprised people are getting any effect at such low doses, but obviously if it works for you keep it that way. As weird as it sounds not only, I don't have any side effects (other than appetite suppression) but cagri seems to fight the fatigue I get from Tirze. So far Cagri is my favorite of all peps I've used (about 15 of them)
 
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Fisherman2356 said:
This is insulting to cagri. Do at least 1mg dude, 0.2mg is nothing. I started (accidentally) with 4mg and never done less than 2mg at once lol. I'm surprised people are getting any effect at such low doses, but obviously if it works for you keep it that way. As weird as it sounds not only, I don't have any side effects (other than appetite suppression) but cagri seems to fight the fatigue I get from Tirze. So far Cagri is my favorite of all peps I've used (about 15 of them)
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Having pride in just how fucked up your hormones and receptors are is one of the weirdest flexes I have seen.
 
chmuse said:
I diluted the fuck out of mine with nothing but bac and will probably use it until the vial is dead since it's in a pen which should have less contamination 🙃

All y'all worried about dementia. At least we'll be SKINNY dementia patients- nurses appreciate that. And skinny old people go faster- they have no protective fat. So we won't even have to be in the skilled nursing facility for long!
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All these folks talmbout dementia with cagri oligomers appear to think the brain is the only place where amyloid deposits. IF the hysteria was that valid, you would have deposits of ologomers protofilaments bla bla bla depositing in the heart structurally damaging it. Folks would die from heart failure before they lost their minds.
Pharma's worry is not largely about Alzheimer's (there may be some future worry)
The primary concern was with the deposits causing local irritation which would lead to unsightly marks (imagine puck-marks for every cagri injection over a lifetime) and also the fact that this greatly reduces efficacy of the meds.
 
Deeubee said:
All these folks talmbout dementia with cagri oligomers appear to think the brain is the only place where amyloid deposits. IF the hysteria was that valid, you would have deposits of ologomers protofilaments bla bla bla depositing in the heart structurally damaging it. Folks would die from heart failure before they lost their minds.
Pharma's worry is not largely about Alzheimer's (there may be some future worry)
The primary concern was with the deposits causing local irritation which would lead to unsightly marks (imagine puck-marks for every cagri injection over a lifetime) and also the fact that this greatly reduces efficacy of the meds.
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I just pinned 3 times this morning am i ok then???
 
Deeubee said:
Don't know about pinning 3 times a day though.. Would be more concerned with side effects 😀
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serious question. I pin myself about 7-10 times daily depending what peps I'm doing that day. Basically, I am pinning each pep by itself. my question is - Is it ok if I combine 4 or 5 peptides in one syringe/one shot(so i only pin once or twice daily), or peptides should not be mixed with one another? I would still keep Tirze and cagri separate but they are weekly anyway.
 
Fisherman2356 said:
serious question. I pin myself about 7-10 times daily depending what peps I'm doing that day. Basically, I am pinning each pep by itself. my question is - Is it ok if I combine 4 or 5 peptides in one syringe/one shot(so i only pin once or twice daily), or peptides should not be mixed with one another? I would still keep Tirze and cagri separate but they are weekly anyway.
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Depends on the peps. There's a chart floating around somewhere. In general though, never mix glp-1's with anything else.
 
Super Trips said:
for me i did a whole 5mg in like 3 weeks or less i was dosing everyday till i felt it then every 3 days or when i needed it i would dose. so i started at .25 and nothing so the next day .25 then i was good for 3 days then i upped it to .5 and im at .75 about to go to 1mg
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wow, I am going to try this. I am only at 0.625 on my 4th week and still not feeling anything. I have been afraid to go up too quickly but at this rate, I think I will try it.
 
jas0441 said:
wow, I am going to try this. I am only at 0.625 on my 4th week and still not feeling anything. I have been afraid to go up too quickly but at this rate, I think I will try it.
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I would try and if you start going to high like 1.5 or 2mg every 3-4 days rotate to Survo or Maz and see if that helps
 
jas0441 said:
wow, I am going to try this. I am only at 0.625 on my 4th week and still not feeling anything. I have been afraid to go up too quickly but at this rate, I think I will try it.
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no appetite suppression at .625? are you sure you got a good batch? so many people say 0.25 or 0.5 knocked them on their ass (it did for me, although yeah i did have to move up relatively more quickly compared to tirz)
 
Fisherman2356 said:
serious question. I pin myself about 7-10 times daily depending what peps I'm doing that day. Basically, I am pinning each pep by itself. my question is - Is it ok if I combine 4 or 5 peptides in one syringe/one shot(so i only pin once or twice daily), or peptides should not be mixed with one another? I would still keep Tirze and cagri separate but they are weekly anyway.
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have you considered the idea you might be a freak lol

the best kind of anon to be on a forum like this. just balls to the wall, all day every day.
 
Super Trips said:
I guess so i tested it at 4.5 and 5.5
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this is interesting, does caine advertise that it's ph buffered? that could be a huge selling point. @Cain_SPC is your cagri ph buffered on purpose?

i just did a new vial recon of my sry cag and i'm going to do a little ph strip on it to see (straight bac)
 
Deeubee said:
All these folks talmbout dementia with cagri oligomers appear to think the brain is the only place where amyloid deposits. IF the hysteria was that valid, you would have deposits of ologomers protofilaments bla bla bla depositing in the heart structurally damaging it. Folks would die from heart failure before they lost their minds.
Pharma's worry is not largely about Alzheimer's (there may be some future worry)
The primary concern was with the deposits causing local irritation which would lead to unsightly marks (imagine puck-marks for every cagri injection over a lifetime) and also the fact that this greatly reduces efficacy of the meds.
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i do have a suspicion cagri might never make it to market, not because it's unsafe, but because it just doesn't perform well enough compared to all the other weight loss drugs in the pipe and maybe because the side effect profile is too high.

i do suspect its ideal use is as an enhancement to a glp1/gipr agonist though, if they deem it safe enough i hope it finds its way to market
 
clayd said:
this is interesting, does caine advertise that it's ph buffered? that could be a huge selling point. @Cain_SPC is your cagri ph buffered on purpose?

i just did a new vial recon of my sry cag and i'm going to do a little ph strip on it to see (straight bac)
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Back in September/October sometime on his TG channel, Cain referenced their Cagri had no buffer.
 
clayd said:
this is interesting, does caine advertise that it's ph buffered? that could be a huge selling point. @Cain_SPC is your cagri ph buffered on purpose?

i just did a new vial recon of my sry cag and i'm going to do a little ph strip on it to see (straight bac)
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sry cag + bac water showed essentially neutral ph on the test strip, no color change.
 
scarywood75 said:
I found a vegan replacement to gelatine when I tried mixing bpc-157 and Tirz together 🤣
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1000012532.jpg



Found it
Agar agar is probably cheaper than your poor peps
 
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