My libido on first dose of Tirzepatide 10mg blunted hard

[andreigl]

I remember way back on the first dose of 2.5mg - yep, my libido was gone on the first 36 hours of the very first injection of Tirzepatide. But throughout the 14 weeks of my weight loss journey, I have been able to combat the loss and even regain and made my libido stronger with 1. Regular 3x per week strength training, 2. daily 5,000iu Vitamin D3 and Magnesium Glycinate 500mg, 3. 1gm of NMN and 2gm of TMG (betaine) on the day, 4. Kisspeptin-10 200mcg shot 7 hours before sex.

These things I did and the supplements I took made me even better than when I was a teenager (the smoking and drinking probably dulled it back then).

Now? Four days in, I feel like a eunuch. Any tips?

 

[andreigl]

Some of my libido came back after 6 days and a half. Pinned 8.75mg instead of 10mg and then 20 hours later, fatigue came back but not as strong as 10mg's. Also, there is still some feeling in my groin (at least not dead like last week).

I guess all the stuff I did can't overcome the strength of Tirzepatide.

 

[Rolltide61]

I remember way back on the first dose of 2.5mg - yep, my libido was gone on the first 36 hours of the very first injection of Tirzepatide. But throughout the 14 weeks of my weight loss journey, I have been able to combat the loss and even regain and made my libido stronger with 1. Regular 3x per week strength training, 2. daily 5,000iu Vitamin D3 and Magnesium Glycinate 500mg, 3. 1gm of NMN and 2gm of TMG (betaine) on the day, 4. Kisspeptin-10 200mcg shot 7 hours before sex.

These things I did and the supplements I took made me even better than when I was a teenager (the smoking and drinking probably dulled it back then).

Now? Four days in, I feel like a eunuch. Any tips?

200mg of Test Cyp. a week. (From a doctor of course)

Your wife will follow you around like a puppy.

 

[AndyPanda]

You can also try enclomiphene and/or hCG. They give you more baby batter and better orgasms as well.

You can get all of it from India relatively cheap, including Testosterone E, C, or P.

 

[andreigl]

OMG, I think I figured it out. You see, I'm also taking GHK-Cu as part of the Glow stack for eight weeks already. I developed some sort of itchiness on the skin a few days ago. It was not any allergic reaction. And I learned, according to some, but disputed by few, that you need zinc supplementation along with the copper peptide - something like magnesium/calcium pairing. The idea is I'm becoming deficient in zinc because of the imbalance.

Anyway, I took 30mg zinc supplements yesterday before pinning hours later GHK-Cu. Results? No itching whatsoever until now. Also my member became harder and more consistent. Google said, "A deficiency in zinc has been linked to erectile dysfunction (ED). Maintaining sufficient zinc levels is thought to help encourage healthy blood flow for strong erections."

CONFIRMED

 

[andreigl]

Update:
So, I believe my high tirzepatide dose (10mg+, currently 15mg) is the culprit on why my member is limp. Regardless of taking TMG, zinc or Kisspeptin-10 or cycling off GHK-Cu, if the dose is strong, you get limp.

Anyway, I watched on Youtube about how 10,000iu of Vitamin D3 builds muscle rapidly according to Thomas DeLauer, I decided to try myself, being in a stall for almost 3 months now.

I haven't seen the results yet on muscles but oh boy! 10,000iu makes your member rock hard. Something to do with enhancing the bioavailability of nitric oxide (NO) and improving endothelial function.

It lasts about 3 days for me in between taking the supplements. Nice! I just jabbed my weekly Tirzepatide dose and still hard when erect.

 

[woundcarping]

🤔 I take 8kiu + 200 mcg of D3K2-7 daily since 1/17/25 and haven't noticed any attributable affects from it.

Unless you're deficient, I don't see how it will rapidly develop muscle and even if you are, I wouldn't expect "rapid" to be an adverb I'd use to describe the results.

I'll have bloodwork again in 2-3 weeks, I expect I'll be able to drop my dose based on those results. I'm targeting 50ng/mL +/- 10ng/mL.

Capillary draws from last month, going forward I plan for all labs of consequence to be venous.

 

[andreigl]

I wouldn't expect "rapid" to be an adverb I'd use to describe the results.

Well, he did. 😂

Anyway back to my sex life...
There are three aspects I have noticed regarding my erectile situation.

1. Mental state - that craving in your head, the actual libido
2. Touch sensitivity
3. Rigidness

High dose Tirzepatide torches all three. However as the week nearly ends, the same time food noise creeps back in, libido (mental state) also creeps back in. Touch sensitivity also returns slowly while only some of the rigidness comes back.

For months, touch and rigidity have been blunted by the GLP-1. Before discovering high dose Vitamin D3, Viagra was the only recourse and it only addresses the rigidity.

I plan to use Kisspeptin along with high dose Vitamin D3 at the end of week before jab day and see if it helps with all three aspects.

 

[Abrakebabra]

Isn't something I've ever experienced on Tirz I must admit. Have you tried PT-141? What you're describing is pretty much it's ideal use case. Can only imagine being in Pattaya and experiencing this is frustrating!

 

[andreigl]

Have you tried PT-141?

No, not yet. I'm a bit hesitant because of the reported "sexual anhedonia" side effect some users had. Maybe when it's really bad. Actually, I'm better off now than 6 years ago when I haven't been exercising and smoke a pack of cigarettes.

The best state I was ever been was during early teens (13 - 16 years old), second was (17 - 25 years old) and next to that. Would you believe it? In my 50s. From 26 - 35 years old, no exercise, heavy smoker, heavy drinker and slowly my tummy getting bigger.

 

[Abrakebabra]

No, not yet. I'm a bit hesitant because of the reported "sexual anhedonia" side effect some users had. Maybe when it's really bad. Actually, I'm better off now than 6 years ago when I haven't been exercising and smoke a pack of cigarettes.

The best state I was ever been was during early teens (13 - 16 years old), second was (17 - 25 years old) and next to that. Would you believe it? In my 50s. From 26 - 35 years old, no exercise, heavy smoker, heavy drinker and slowly my tummy getting bigger.

The safety profile from the studies I've seen doesn't seem to mention that - perhaps more anecdotal. Either way I've not used myself so certainly can't advocate, but just another option if needed.

Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder - PMC

The 52-week open-label extension of the RECONNECT studies demonstrates bremelanotide's favorable safety profile, with sustained efficacy in treating hypoactive sexual desire disorder in premenopausal women.

pmc.ncbi.nlm.nih.gov

 

[tubby]

You're awful quick to dismiss the PT-141. Are you sure the "sexual anhedonia" isn't just a description of going back to normal after the effect wears off?

 

[andreigl]

You're awful quick to dismiss the PT-141. Are you sure the "sexual anhedonia" isn't just a description of going back to normal after the effect wears off?

No..... It was a Reddit post where the OP described PT-141 was great at first but one day during sex when he was about to have orgasm, he felt nothing as it came out. The effect lasted for weeks he said. It reminded me of that long time user of finasteride that permanently lost his erection. It scared me to put off buying and look for other alternatives.

Although he said he was a former drug user, maybe it messed up his body. I don't know. Like I said if one day it becomes a problem between my wife and I, I will definitely try it next.