NAD+ - big doses?

[mikkyglue]

I keep thinking about trying NAD+ subQ, but keep hearing so much wildly varying opinions on it. I've been taking NMN for 2 years now.

I read that s/c NAD doesn't have any real advantage over oral NMN & NR. I'm curious about other people's experiences.

 

[Commander]

I am taking 50mg NAD. I don’t really think it does anything by itself, but the reason I am taking it is because I am also taking SS-31 and MOTS-C.

 

[tendency]

I read that s/c NAD doesn't have any real advantage over oral NMN & NR. I'm curious about other people's experiences.

The precursors - NMN/NR - never did anything for me that I could tell. NAD+ subq gives me a nice bump in energy and mood that lasts all day.

 

[homebrew]

I had been testing 50mg of NAD+ 3x weekly (along with oral TMG daily) for several months with no apparent effect. I then tested 2 weeks of daily 100mg NAD+, still no effect, so I've stopped. I'm thinking, because I'm 71 years young, I probably lack enough healthy mitochondria for the NAD+ to be effective. Similar concerns about BPC-157 effectivity (also currently paused).
I curious about SS-31 and whether it would help systemically with the other peptides. Any opinions on SS-31 ?

 

[slick1]

Anything with the gluteus concerns me about hitting something like the sciatic nerve or the superior gluteal artery.

Pretty sure doctors have been giving shots in the ass with 2" needles for 100 years.😱

 

[Commander]

I had been testing 50mg of NAD+ 3x weekly (along with oral TMG daily) for several months with no apparent effect. I then tested 2 weeks of daily 100mg NAD+, still no effect, so I've stopped. I'm thinking, because I'm 71 years young, I probably lack enough healthy mitochondria for the NAD+ to be effective. Similar concerns about BPC-157 effectivity (also currently paused).
I curious about SS-31 and whether it would help systemically with the other peptides. Any opinions on SS-31 ?

SS-31 helped me. You have to do 4mg a day. Some people will tell you that you can do a lot less… I only got a benefit from 4mg a day, I am 54

 

[rpm2026]

So I've been running 50mg of NAD+ daily the last 3-3.5 months. Took a couple months before I started to feel a small boost in energy and improvement in mood. It was subtle, but noticeable. Nothing dramatic.

Just for fun, I decided to really crank my dosage and last 3 days have taken 250mg daily. And wow, wow. That hits. Really nice increase in energy that's smooth, stable and lasts all day. Significant improvement in mood.

Anyone else relate to this? Anyone else have to take, or notice significant improvement, when taking a mammoth dose?

I had an extreme reaction to taking a very high dose of NAD+ which included a panic attack and extreme pressure in my chest. Be very careful.

 

[Powerslide]

I had an extreme reaction to taking a very high dose of NAD+ which included a panic attack and extreme pressure in my chest. Be very careful.

How high of a dose? Why do these people go from banging 100mg to 250 or 500mg? Why not 125-150?

 

[rpm2026]

How high of a dose? Why do these people go from banging 100mg to 250 or 500mg? Why not 125-150?

I think it was around 250mgs it was a reconstitution error and I plunged it too quick. Very scary. Every muscle in my body seized for a few minutes. I thought about calling 911 but was sure I would be dead before they got there anyway!

 

[Jrammi]

So I've been running 50mg of NAD+ daily the last 3-3.5 months. Took a couple months before I started to feel a small boost in energy and improvement in mood. It was subtle, but noticeable. Nothing dramatic.

Just for fun, I decided to really crank my dosage and last 3 days have taken 250mg daily. And wow, wow. That hits. Really nice increase in energy that's smooth, stable and lasts all day. Significant improvement in mood.

Anyone else relate to this? Anyone else have to take, or notice significant improvement, when taking a mammoth dose?

I also take 250mg / daily and feel great! Hopefully, long term no issues...

 

[tendency]

No. I heard Dr. Paul Jones talk about the difficulty measuring. Unstable in blood and blood does not represent qty in organs and tissues. Similar probs measuring Glutathione.

The science says NAD is definitely doing it's job. Whether the cellular environment is ready to use it is why we geek out on the MOTS/SS31 Mito health path. I'm convinced it's working behind the scenes for me, catch a flush at 100mg, but am not banking on the energy rise. That said, you bet I wanna blast 500mg to see what it's like. Common IV dose is 750ml. The other research rat and I both get some gastro going on pin day.
I'm messing with 100mg 3x weekly. Clinics (Konniver and Jones) use a "loading dose" --100mg for week then come back for the IV big bag. Patients then return 1x monthly or once weekly depending.

I'm not sure the science says NAD+ injections, or NAD augmentation with pre-cursors, does much of anything for many.