New 5 Receptor Agonist

Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
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30% on average maybe.

There are people in Retatrutide trials who only lost 5% of their weight after nearly a year on it. I'm sure they would appreciate another option!

Also for some people 30% might not be enough. What if your starting weight is 300lb+? You take Reta, stall at 210, maybe you'd want something stronger to get you to into the 100s.
 

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Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
Click to expand...
Sometimes the benefit is stuff like mitigated side effects, or better treatment of insulin resistance. But yeah, I'm not going to watch an hour-long video.
 
AI Summary:

The video explains how GLP-1–type weight loss drugs are evolving from single → dual → triple → even 5-receptor agonists, and why that matters.

The key idea

•Older drugs targeted just one receptor (GLP-1) → helped with appetite and blood sugar

•Newer ones target multiple receptors at once to amplify results

Triple agonists (current “next step”)

•Hit 3 receptors: GLP-1 + GIP + glucagon

•Result: more weight loss and better metabolic effects than older drugs

•Example: retatrutide (still being studied)

5-receptor agonists (what’s new)

•Experimental drugs now target 5 different pathways (adding things like PPAR receptors)

•Goal:

-Even greater fat loss

-Better metabolic health (liver, insulin, etc.)

-Potentially fewer side effects by spreading the effects across pathways

Big takeaway

•The shift isn’t just “stronger drugs”—it’s smarter, multi-pathway drugs

•The idea is: instead of pushing one system hard, gently influence several systems at once for better results
 
Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
Click to expand...
If you are like me and trying to maintain a 55% weight loss. These drugs are designed for people with severe obesity ( and to a lesser extent those with moderate obesity ) , and for that group with BMI's over 40 or 45 even reta is not good enough, and why so many people on this forum with severe obesity are using combinations of GLP's and amylin agonists. Given the only currently available legit therapy for severe obesity is tirzepatide or bariatric surgery, better therapies that reduce the need for pretty severe surgery, or experimental and unproven combinations, sounds like a very useful treatment.
 
Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
Click to expand...
Would help for people like me who maxed out on Mounjaro and stalled but still hasn't reached goal weight with reta, I still have around 75lbs-85lbs to lose.
 
Personally I look forward to better weight loss drugs. By the time this hits the market I will have hit my goal long before. It was hard for me to take the guy in the video seriously. His face was so fat, and his hands so puffy that I just don't find him credible on the subject of weight loss. I didn't watch the whole video.

With the money generated from weight loss drugs, and people eating record amounts of processed foods. We can expect more drugs and protocols to hit the market. Money will be flowing into R&D as well as the products that they produce. Weight loss was a Billion dollar business even before GLP's. Between books, classes, gyms, drugs, businesses like weight watchers and other healthy food delivery services, home exercise equipment, there were lots of options for us to spend our money on. A once a week pill or injection is every fat person's dream.
 
Lovedog100 said:
Personally I look forward to better weight loss drugs. By the time this hits the market I will have hit my goal long before. It was hard for me to take the guy in the video seriously. His face was so fat, and his hands so puffy that I just don't find him credible on the subject of weight loss. I didn't watch the whole video.

With the money generated from weight loss drugs, and people eating record amounts of processed foods. We can expect more drugs and protocols to hit the market. Money will be flowing into R&D as well as the products that they produce. Weight loss was a Billion dollar business even before GLP's. Between books, classes, gyms, drugs, businesses like weight watchers and other healthy food delivery services, home exercise equipment, there were lots of options for us to spend our money on. A once a week pill or injection is every fat person's dream.
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I agree it's incredible we're literally on the cusp of chronic obesity being cured. Once these drugs patents expire and generics are readily available obesity would essentially become optional.

We've already seen a huge shift towards fitness since gen z is more health focused and everything you buy nowadays being labelled as "high protein" to attract fitness enthusiasts.

We're going to be seeing massive shifts in big food and health spaces.
 
Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
Click to expand...
Take me for example. I started at 334 .. losing 30% would put me at 234. Still obese. I need to lose about 50% of my starting weight.

Also not everyone reacts the same to each receptor ... having options is always a good thing.
 
As far as I can tell most of the high protein foods that have recently become available are not especially healthy, just slightly higher protein versions of ultra processed foods, so I guess they might make you feel full for a bit longer than the standard versions, but that is about it.
 
This is exciting for the intended audience but I think triple agonist should have a longer study on it before moving to five. This is marathon, not a sprint and sometimes I think medicine moves too fast for money/trademarks etc.

Just my two cents.
 
deleted.user.16 said:
30% on average maybe.

There are people in Retatrutide trials who only lost 5% of their weight after nearly a year on it. I'm sure they would appreciate another option!

Also for some people 30% might not be enough. What if your starting weight is 300lb+? You take Reta, stall at 210, maybe you'd want something stronger The idea that we just need a stronger drug misses how these actually work.
Click to expand...

Even with something like Retatrutide, the average results of weight loss do not happen in a vacuum. These drugs enhance your body’s metabolic signals, they do not override them.

If someone only loses 5%, it is usually not because the drug is not strong enough. It is often a sign something deeper is going on metabolically.

Things like insulin resistance with high fasting insulin, chronic inflammation like elevated CRP, thyroid dysfunction, and hormonal imbalances especially in women can all blunt response. The medication isn't failing... The foundation is broke.

But also how you support the medication matters just as much.

If you are undereating or starving, your body will downregulate and fight you.
If protein intake is too low, you lose lean mass instead of fat.
If you are not doing resistance training, you are not giving your body a reason to preserve muscle or keep metabolism higher.
Low daily movement can cancel out a deficit.

So throwing a stronger multi receptor agonist at the problem does not necessarily fix it.

For someone starting at 300+ pounds, getting to 210 is not a failure, that is a massive metabolic shift. If progress stalls there, it usually means the body is defending that weight and there is still underlying physiology and habits to address, not just escalate meds.

The better question is what is preventing the body from responding fully and are we actually meeting the medication halfway
 
MsGizmo said:
Take me for example. I started at 334 .. losing 30% would put me at 234. Still obese. I need to lose about 50% of my starting weight.

Also not everyone reacts the same to each receptor ... having options is always a good thing.
Click to expand...
I get what you’re saying, and I agree having more options is a good thing.
But that 30% from Retatrutide trials isn’t a ceiling, it’s just an average under a very specific protocol. Everyone is titrated up on a set schedule and the results are based on that, not on people actually optimizing things.
Those studies also don’t focus on the basics at all. They’re not built around people staying at the lowest effective dose, eating enough protein, lifting weights a few times a week, sleeping well, managing stress, or adjusting calories as they lose.
That’s where a lot of people leave results on the table.
In real life, when you actually combine the meds with those things, people can go well past the study averages because they’re improving their metabolic health, not just relying on the drug.
So yeah, if someone starts at 334 and wants more than 30%, that makes total sense. But it’s not always about needing something stronger, sometimes it’s about whether the foundations are really dialed in.
 
I don't think it will get close to passing trials, huge potential for big risks, Amylin brings an even slower digestion, removes cravings (positive) and keeps you full for extended periods, this brings higher risk of heart burn, eating much less than the desired amount to keep you healthy, then comes in Calcitonin, which completely shuts the off brain from the hunger signals, I'm a huge supporter of GLP-1's when it supports weight loss and mental health, but I'm a big believer of doing both GLP's while making a difference with a healthy lifestyle, this comes with meal planning, eating consistently, creating something that you could potentially keep the weight down choosing this healthy life style, completely shutting the mind from hunger and less food intake is a wrecking ball waiting to happen.
 
Beardboost said:
I don't think it will get close to passing trials, huge potential for big risks, Amylin brings an even slower digestion, removes cravings (positive) and keeps you full for extended periods, this brings higher risk of heart burn, eating much less than the desired amount to keep you healthy, then comes in Calcitonin, which completely shuts the off brain from the hunger signals, I'm a huge supporter of GLP-1's when it supports weight loss and mental health, but I'm a big believer of doing both GLP's while making a difference with a healthy lifestyle, this comes with meal planning, eating consistently, creating something that you could potentially keep the weight down choosing this healthy life style, completely shutting the mind from hunger and less food intake is a wrecking ball waiting to happen.
Click to expand...
There are quite a few people on this forum who are already effectively taking something very similar, reta plus cagrilintide and having it work quite well.
The obvious case where GLP medications are less effective for weight loss is in diabetics, where despite excellent effects on blood sugar levels, weight loss is typically quite a bit less than in non diabetics, to the point where the studies on weight loss are done separately for diabetics and non diabetics. Another group that could benefit from better GLP drugs.
I would be interested to know how severe the obesity is that Beardboost is treating with GLP's plus lifestyle , diet and exercise. The attitude that GLP's are a relatively small part of the solution often seems to be from people who do not have severe obesity. Feel free to correct me if I am wrong in guessing that that is where this poster is coming from.
For those with more severe obesity who often have spent decades trying to lose and maintain weight with diet, exercise and lifestyle modifications, and having those methods succeed only temporarily at best, GLP medications are the solution. And subsequently make lifestyle and diet and exercise changes easier, and more likely to be persisted with. They are not irrelevant, but often decades of experience and a lot of scientific studies show that they are largely ineffective at achieving or maintaining large weight losses, except for a lucky or especially persistent few. Whereas GLP medications have very good rates of success, although not for every one, and maintain that weight loss long term if you stay on the medication.
 
IvanD said:
This is exciting for the intended audience but I think triple agonist should have a longer study on it before moving to five. This is marathon, not a sprint and sometimes I think medicine moves too fast for money/trademarks etc.

Just my two cents.
Click to expand...
Dont' worry, there's at least a dozen studies coming from Lilly on retatrutide, which will help them prescribe it for a variety of metabolic issues.
 
Vash_ said:
Honestly, what’s the point? Reta is already shown to cut 30% of peoples body weight. That’s ridiculous enough. Why would anyone need something more effective?
Click to expand...
The former 600lb me, wouldn't mind so much and keeping most of the muscle mass would be good. Inching closer to things that help people in wheel chairs, elderly would be a good thing.
 
Last edited:
lessthanhalf said:
There are quite a few people on this forum who are already effectively taking something very similar, reta plus cagrilintide and having it work quite well.
The obvious case where GLP medications are less effective for weight loss is in diabetics, where despite excellent effects on blood sugar levels, weight loss is typically quite a bit less than in non diabetics, to the point where the studies on weight loss are done separately for diabetics and non diabetics. Another group that could benefit from better GLP drugs.
I would be interested to know how severe the obesity is that Beardboost is treating with GLP's plus lifestyle , diet and exercise. The attitude that GLP's are a relatively small part of the solution often seems to be from people who do not have severe obesity. Feel free to correct me if I am wrong in guessing that that is where this poster is coming from.
For those with more severe obesity who often have spent decades trying to lose and maintain weight with diet, exercise and lifestyle modifications, and having those methods succeed only temporarily at best, GLP medications are the solution. And subsequently make lifestyle and diet and exercise changes easier, and more likely to be persisted with. They are not irrelevant, but often decades of experience and a lot of scientific studies show that they are largely ineffective at achieving or maintaining large weight losses, except for a lucky or especially persistent few. Whereas GLP medications have very good rates of success, although not for every one, and maintain that weight loss long term if you stay on the medication.
Click to expand...
I actually agree with part of what you’re saying, especially around severe obesity. For a lot of people, meds are the first thing that actually works long term after years of trying everything else.
And yes, outcomes are different in diabetics vs non diabetics, that’s well established.
But I think it’s a stretch to say the meds are the solution and everything else is mostly ineffective for this population
Even with things like Retaor stacking with Cagri, the medication is changing appetite, satiety, and glucose handling. It’s not replacing the underlying physiology.
For people with severe obesity, those underlying issues are usually more pronounced, not less. Higher insulin levels, more metabolic adaptation, more resistance to weight loss. That doesn’t go away just because the medication is stronger.
Also, a lot of people have done diet and exercise before, but not in a way that preserves muscle, supports metabolism, or is actually sustainable. There’s a big difference between years of under eating and cardio versus adequately fueling, prioritizing protein, and doing consistent resistance training.
The meds make those things easier, 100%. But they still matter a lot for how far someone gets and whether they stall.
So I don’t see it as meds vs lifestyle.
It’s more that the meds finally make the lifestyle changes work the way they were supposed to in the first place.
 
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