I’ve had good success with Nexaph, and when something was off Cain has made it right. I’ve never bought Lipo-C from them but he posted the following on their Telegram yesterday…
“Hello everyone,
I want to take a moment to address the recent testing results related to our Lipo-C product. Some have expressed concern that my team and I are avoiding the issue, but I want to assure you that we’ve been actively investigating what happened behind the scenes. Our goal is full transparency and accountability.
1. B12 Source Confirmation
I contacted our supplier to verify the type of B12 used in the Lipo-C blend. They confirmed that they supplied cyanocobalamin, not hydroxocobalamin.
2. Understanding the B12 Result
We researched how cyanocobalamin might have appeared as hydroxocobalamin in the test. It turns out this transformation is chemically possible. Here’s what we found:
• Hydroxocobalamin can form as a degradation product of cyanocobalamin, particularly under certain conditions like prolonged exposure to water, light, heat, or extremes in pH.
• Mechanism:
Cyanocobalamin contains a cyanide group (-CN) bonded to a cobalt center. In aqueous or light-exposed environments, the cyanide group can be displaced by a hydroxyl group (-OH), converting it to hydroxocobalamin.
• Hydrolysis:
Cyanocobalamin + H₂O → Hydroxocobalamin + HCN
• Photolysis:
Light exposure can also cause this bond to break, especially during extended storage.
• Summary:
• Yes, hydroxocobalamin can form from cyanocobalamin under the right conditions.
• It’s a slower and more stable degradation pathway than that of methylcobalamin.
• The shift is more likely in water-based, light-exposed, or improperly stored solutions.
3. About the L-Carnitine Overfill
We also noticed an overfill in the L-carnitine concentration. It’s important to note that amino acid blends are notoriously difficult to test accurately, which is why Janoshik doesn’t/wont test all of the ingredients in the mixture. I commend their lab for even attempting to test this blend.
We mix batches in 10,000 mL lots and weigh 600g of L-carnitine per batch. A 10% overfill would still only bring it to ~60 mg/mL, which doesn’t align with what testing indicated and just highlights the difficulties of testing blends.
4. What Does This Mean for the Product?
We understand that the term “degradation product” might sound alarming—but in this case, hydroxocobalamin is not a harmful impurity. On the contrary, it’s actually a more bioavailable and therapeutically active form of B12 than cyanocobalamin. The conversion likely happened during storage, and while it wasn’t intentional, the end result is not unsafe—in fact, it may have enhanced the product’s efficacy.
That said, we know this wasn’t what was expected, and we fully understand how frustrating this situation may be. We genuinely appreciate your patience and understanding as we work to prevent this from happening again.
⸻
Going Forward
To improve future batches and limit the possibility of similar changes, we’re implementing the following measures:
1. Amber Vials – To reduce light exposure and preserve B12 integrity.
2. Vacuum Sealing – To minimize oxidative stress during storage.
3. Batch Labeling – All Lipo-C blends will now include detailed batch info, just like our other products.
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We understand that testing complex blends doesn’t always give a complete picture. But we remain committed to full transparency and quality. We ask for your continued trust as we refine and improve our processes. Your support means everything to us.”
I saw Cain posted that tirz is restocked but testing isn't for 1-2 weeks. Not sure where to go from there about getting a tested product.
