To whoever comes across these vials ....
A group of us who bought Reta 12 mg / neon green caps, purple crimp in October 2024 decided to re-test the batch as it was originally under - performing at 97 - 98 % purity. With the help of Sabrina F, who has lab access we sent in a bunch of vials and got the results today. I am posting Sabrina's comments with her test results here. I am sincerely hoping that none of us in this community will be tempted to use this product and I am also hoping that , by making the test results public that we will spot it right away if someone should try to sell it anywhere in the servers.
To be fair to Cain and Nexaph, the Reta got re-shipped /replaced to all of us who bought it.
Attached you find the test results that were completed today.
Here are Sabrina's comments, I have her permission to share them with you:
"I won’t make any bold claims as to what is going on. The tests indicate:
Degradation due to oxidation
Possibly worsened by the fact that this might be Na form of the compound
Degradation has caused some changes in sensitive residues which usually happens when a peptide degrades
NMR showed a degradation of the product (point in time) of about 89-92% (again this is not HPLC)
Mass does not conform but this is what we have been seeing in many other tests the mass around ~4728-4730 g/mol. Per ICH standards this is off, per research guidelines it’s fine. Purity per research standard passes for both MS and NMR. No TFA detected.
Again everyone has their own tolerance risks, this is just the tests results at this time to how they showed up. Might have been better before might be the same or worse later we won’t know if we do not test.
I try to be as objective and scientific while providing explanations that make sense."
A group of us who bought Reta 12 mg / neon green caps, purple crimp in October 2024 decided to re-test the batch as it was originally under - performing at 97 - 98 % purity. With the help of Sabrina F, who has lab access we sent in a bunch of vials and got the results today. I am posting Sabrina's comments with her test results here. I am sincerely hoping that none of us in this community will be tempted to use this product and I am also hoping that , by making the test results public that we will spot it right away if someone should try to sell it anywhere in the servers.
To be fair to Cain and Nexaph, the Reta got re-shipped /replaced to all of us who bought it.
Attached you find the test results that were completed today.
Here are Sabrina's comments, I have her permission to share them with you:
"I won’t make any bold claims as to what is going on. The tests indicate:
Degradation due to oxidation
Possibly worsened by the fact that this might be Na form of the compound
Degradation has caused some changes in sensitive residues which usually happens when a peptide degrades
NMR showed a degradation of the product (point in time) of about 89-92% (again this is not HPLC)
Mass does not conform but this is what we have been seeing in many other tests the mass around ~4728-4730 g/mol. Per ICH standards this is off, per research guidelines it’s fine. Purity per research standard passes for both MS and NMR. No TFA detected.
Again everyone has their own tolerance risks, this is just the tests results at this time to how they showed up. Might have been better before might be the same or worse later we won’t know if we do not test.
I try to be as objective and scientific while providing explanations that make sense."