Normal side effects?

Frankbooth

Frankbooth

GLP-1 Apprentice
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Jan 4, 2026
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I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
 
Sorry, but in what timeframe did you take the 5mg..how long?
Did you do the normal trials titration and begun with 2mg?
 
Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
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why would you double it? not very smart from you bro
 
This does sound like a good recipe for how to put yourself in hospital with dehydration from taking GLP's, all you need to get there for sure is add vomiting to the mix.
I do not understand any part of the reason for increasing the dose when side effects were already a problem. The only sensible course of action is to stop it until the side effects settle down, then restart at a lower dose. Or in this case maybe don't restart until you have read a lot more about them and have some idea of how to use them safely.
 
Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
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Some of us warned you in an earlier post not to titrate up on dosage so fast but you didn't listen did you? You got what you deserved. Bet it sucks to be you right now!
 
You were warned, MULTIPLE times not to do this. If you’re not going to take advice from the people on this forum who have actually spent time reading and have real-life application experience with these peptides, why do you even post? Your reckless behavior will get you in a bind in a hurry.

Dos-Dox said:
This is a recipe for some unpleasant sides as that’s a huge jump. Keep in mind that reta has a half life of about 6 days, so at only 5 weeks in and steadily increasing as quickly as you have, you haven’t yet felt the effects of a steady-state dosage. Most recommend holding a dose for 4-5 weeks before titrating up again.
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Dos-Dox said:
You were warned, MULTIPLE times not to do this. If you’re not going to take advice from the people on this forum who have actually spent time reading and have real-life application experience with these peptides, why do you even post? Your reckless behavior will get you in a bind in a hurry.
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Exactly! Sorry to say this but he doesn't seem like the sharpest tool in the shed for sure!
 
You’re spot on, @CMA Pooky. This might be the first person to actually get under my skin on this forum. Every time someone like this shows up in the ER because of reckless behavior like this, it just puts the spotlight more on the industry and makes “crack-downs” more inevitable. This user needs a special forum banner that says “don’t bother. Won’t listen to advice” or something like that.

I’m running a little short on sympathy, but I do hope OP gets to feeling better soon and has no life-altering repercussions.
 
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I was not actually joking about it being a good way to end up in hospital. The most common reason by far to end up there when starting glp's is the combination of nausea, vomiting and diarrhoea causing dehydration . And it happens a lot with grey peptides either because of getting mixed up about doses and accidentally giving yourself 2 or 10 times the correct amount, and/or the lack of medical advice on side effects and how to deal with them. In this case apparently you were warned about dose escalation, the problem with these medications is the week long half life so if you do have a dose causing bad side effects it can take a week or more to get better, so if you cannot get enough fluids in the only way to fix it if anti nausea medications don't work is a iv line for fluids in hospital until the drug reduces in level.
 
Dos-Dox said:
You’re spot on, @CMA Pooky. This might be the first person to actually get under my skin me on this forum. Every time someone like this shows up in the ER because of reckless behavior like this, it just puts the spotlight more on the industry and makes “crack-downs” more inevitable. This user needs a special forum banner that says “don’t bother. Won’t listen to advice” or something like that.

I’m running a little short on sympathy, but I do hope OP gets to feeling better soon and has no life-altering repercussions.
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I can understand why people like this get under your skin. I'm going to ignore any new posts from him from now on. If you don't listen to feedback, that is your prerogative, but then don't complain later on if there are repercussions.
 
Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
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WholesomeApril said:
I think this guy is just here to rage bait

His intro says he had been reading for a month. Surely anybody that had been reading this forum for a month would know better.
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No, ive been on 5mg for like 5 injections and moved to 10mg, that's not really rage baiting, it's what I tried. I see I should've moved to either 6mg or 8mg if I wanted to move up, its just a mistake, but now im going to go back down to 2.5mg and if that's good for some weeks with no horrible sides, ill do 4mg and then 6mg etc.
 
Besides keeping the dose low, splitting reta (or other GLP) to at least twice a week helps too.

Except for really low doses, I get diarrhea with all the GLPs I have tried (reta, tirz, sema, survo, lira, orfo). So you won't see me buying T100 or R100, haha.

Have you considered cagri as way to boost a low dose of reta? I keep forgetting to try it again. I have only been on 250 mcg of cagri and only used it twice. But no effects either way at that dose.

For the long-term, the probiotic in Florastor Advanced (Saccharomyces boulardii) seems to help somewhat with my GLP-induced diarrhea. But not enough to be able to raise the GLP dose.
 
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Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
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I’m dying rn 🤣🤣 I was reading the first sentence so seriously but burst out laughing at the second sentence.

On a serious note, pls research carefully and titrate up slowly and LISTEN TO YOUR BODY.

Thoughts and prayers lmaooooo
 
Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
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What? Why?
Season 4 No GIF
 
Frankbooth said:
I was doing 5mg a week and had diarrhea for a couple of days after injection. I injected 10mg last night and the side effects are brutal for me on waking up: heavy sweating unless im in super cold AC, diarrhea of course, hurt stomach, a bit of a headache. The main issue being the hurt stomach and diarrhea
Click to expand...
Let's look at your accumulation plot from GLP-1 Plotter. https://glp1plotter.com/
I'm not sure if I have this exactly right but it seems like you started about Jan. 1st at 2.5mg for 2 weeks and then upped to 5mg on week 3. The best I can tell you went a couple of weeks and bumped it up to 10?
First your expected accumulation @ 2.5mg once a week over a 12 week period.
You peaked at 3.1mg, if you had continued at this dose you would have seen 3.8mg in the 4th week.

2.5.png

After the 2nd week you upped it to 5mg for your 3rd week(?) which would give you a peak of 5.6mg. your first week 6.9mg the second. if you had continued at this dose for 4 weeks you would have seen 7.8mg.

2.5 5 2weeks.png

After 2 weeks of 5mg you upped it to 10mg(?) which would give you a 1st week peak of 11.5mg and if continued 15.6mg 4 weeks later.

10mg.png

The operative idea here is "peaks and troughs" are bad news you body needs time to adjust.
Extremes in a short period is a recipe for bad side effects. Slamming your system like this can possibly cause tolerance issues as well.
Long story short, I hope you feel better soon and learned something.

Edit: About that Thai water... I hope you're using Hospira. 😆
 
RetCurious said:
Let's look at your accumulation plot from GLP-1 Plotter. https://glp1plotter.com/
I'm not sure if I have this exactly right but it seems like you started about Jan. 1st at 2.5mg for 2 weeks and then upped to 5mg on week 3. The best I can tell you went a couple of weeks and bumped it up to 10?
First your expected accumulation @ 2.5mg once a week over a 12 week period.
You peaked at 3.1mg, if you had continued at this dose you would have seen 3.8mg in the 4th week.

View attachment 15461

After the 2nd week you upped it to 5mg for your 3rd week(?) which would give you a peak of 5.6mg. your first week 6.9mg the second. if you had continued at this dose for 4 weeks you would have seen 7.8mg.

View attachment 15463

After 2 weeks of 5mg you upped it to 10mg(?) which would give you a 1st week peak of 11.5mg and if continued 15.6mg 4 weeks later.

View attachment 15466

The operative idea here is "peaks and troughs" are bad news you body needs time to adjust.
Extremes in a short period is a recipe for bad side effects. Slamming your system like this can possibly cause tolerance issues as well.
Long story short, I hope you feel better soon and learned something.

Edit: About that Thai water... I hope you're using Hospira. 😆
Click to expand...
I don't remember the date I started but here's how it went I think:

2.5mg for the first 2 weeks (2 injections)
5mg for 5 weeks (5 injections)
10mg for 1 week (1 injection)

Actually, after suffering for 24 hours or so from the side effects from 10mg, I'm pretty ok now, not 100% but I'm not suffering now and the diarrhea is gone but I still have a little bit of stomach grumbling

I think what I'll do next is do 2.5mg injections again and see how the side effects are. And if it's all good then switch to 4mg injections after a few weeks, and then 6mg etc. I'll probably titrate up to a new dose after 4 injections like what's recommended as far as I know.

For water I'm using bac water that I bought from the Thai supplier I bought from. But I'm about to get my order from China, a source that I've seen on this forum. I don't think the bac water I'm using has any impact on my side affects tho
 
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