On Tirzepatide, call me Skinny Sleeping Beauty

[AngeluzFun]

I need help, I need to sleep so much on Tirzepatide. The worse is that I enjoy so much my 3-4 hours siestas, I don't want to do anyting else. May be Tirzepatide? O I 've got depression? I'm taking vitamines and minerals. How can I get out of bed? Could anybody recommend another peptide for energy? TIA, and good night.

 

[stephie]

idk maybe a lower dose? I'm not an expert. but I felt like that on sema, it was awful.... now I'm on tirz and feel fine. 🤷🏼‍♀️

 

[Brdss]

I need help, I need to sleep so much on Tirzepatide. The worse is that I enjoy so much my 3-4 hours siestas, I don't want to do anyting else. May be Tirzepatide? O I 've got depression? I'm taking vitamines and minerals. How can I get out of bed? Could anybody recommend another peptide for energy? TIA, and good night.

Tesofensine might help if you are not on antidepressants

 

[Calm Logic]

Google Gemini seems positive about teso:

Yes, tesofensine can help with energy levels. This is primarily due to its mechanism of action as a triple monoamine reuptake inhibitor, affecting dopamine, norepinephrine, and serotonin. Here's how it can influence energy:

• Increased Norepinephrine and Dopamine:These neurotransmitters are strongly associated with alertness, focus, motivation, and overall energy. By increasing their levels in the brain, tesofensine can lead to:
  • Enhanced drive and motivation: This can make it easier to engage in physical activity and daily tasks.
    
    
  • Improved alertness and focus: Some users may experience a reduction in fatigue and better concentration.
• Increased Resting Energy Expenditure (Metabolism): Tesofensine has been shown to increase the body's basal metabolic rate, meaning you burn more calories even at rest. This increased metabolic activity can contribute to a feeling of greater energy, as your body is more efficiently using and producing energy.
  
  
• Improved Mood: While primarily a weight loss drug, by influencing serotonin and dopamine, tesofensine can have positive effects on mood. When mood is improved, individuals often report feeling more energetic and less lethargic.

It's important to remember that individual responses can vary. While many people experience an increase in energy with tesofensine, some might experience side effects like insomnia, which could counteract the energy-boosting effects for those individuals.8 As with any medication, it's best to discuss its effects and potential side effects with a healthcare professional.

Tesofensine is a medication that works as a triple monoamine reuptake inhibitor. In simpler terms, it boosts the levels of three crucial brain chemicals: dopamine, serotonin, and norepinephrine. These chemicals are vital for regulating appetite, mood, energy, and metabolism.

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From Neurological Treatment to Weight Loss Aid​

Initially, tesofensine was being studied for conditions like Parkinson's and Alzheimer's diseases. However, during clinical trials, researchers noticed a significant and unexpected side effect: weight loss. This discovery shifted its focus, leading to its development as a potential treatment for obesity.

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How Tesofensine Helps with Weight Loss​

Tesofensine's ability to aid weight loss stems from several mechanisms:

• Appetite Suppression: By increasing dopamine, serotonin, and norepinephrine, it helps reduce hunger and cravings. This makes you feel fuller faster and naturally eat less.
• Increased Metabolism: Tesofensine can also increase the number of calories your body burns at rest and might enhance fat burning, contributing to overall weight reduction.
• Brain Activity Modulation: It influences a specific part of the brain called the lateral hypothalamus, which plays a role in feeding behavior.
• Mood and Cognitive Benefits: Some studies suggest it could positively impact mood and thinking, which might help with emotional eating and boost motivation.

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Current Status and Side Effects​

Tesofensine has gone through clinical trials for obesity and has shown promising results, with many individuals achieving significant weight loss (often 5-10% or more of their body weight over several months).

Like any medication, tesofensine can have side effects. Common ones include dry mouth, headache, nausea, insomnia, diarrhea, and constipation. Some people might also experience an increased heart rate, and less commonly, elevated blood pressure. Ongoing research continues to evaluate its long-term effects and safety. If you're considering tesofensine, it's crucial to use it under medical supervision as part of a comprehensive weight management plan.

Though teso has a good safety profile, one experience with teso that would make me want to start slow (as with everything else):

I’ve take this before and it can cause quite disturbing side effects including auditory, visual, and tactile hallucinations. Please do your research on any research medications or for that matter any FDA approved medication before taking it. I’ve been an RN for 33 years and you would think I’d have followed that advice myself. Not doing so landed me in the hospital for a week before we realized it was Teso.

Some stimulants are mentioned here:

Post in thread 'Anger issues with Tesofensine'

May 20, 2025

I'm prone to anxiety but had only clean energy with AndyPanda-approved clenbuterol.

• Calm Logic

• 

 

[AKC97]

Get a full iron panel if you haven't before.

 

[Calm Logic]

Some other tests that may help:

Post in thread 'Fitomics Research Labs Discount Blood Testing'

May 20, 2025

Another panel at Fitomics, but I would just pick-and-choose and add Vitamin D at least:

Common GLP-1 Weight Management Panel​

Sale Price:$70.99 Original Price:$188.65


Complete Blood Count (CBC) With Differential

Metabolic Panel (14), Comprehensive

Ferritin

Vitamin B12 and Folate

Iron and Total Iron-binding Capacity (TIBC)

Lipid Panel With Apolipoprotein B (ApoB)

Triiodothyronine (T3), Free

Thyroid-stimulating Hormone (TSH) and Free T4

• Calm Logic

 

[FlowerFairy]

I need help, I need to sleep so much on Tirzepatide. The worse is that I enjoy so much my 3-4 hours siestas, I don't want to do anyting else. May be Tirzepatide? O I 've got depression? I'm taking vitamines and minerals. How can I get out of bed? Could anybody recommend another peptide for energy? TIA, and good night.

I was the same way- I did what I absolutely had to do. Combine that with food not tasting good and I was living on protein shakes and sleeping. Granted, I was depressed at the time as well, but I’ve had treatment resistant depression my entire life. And yep, got all the labs suggested in this thread except ferritin- I’m on polysaccharide iron complex daily, so as long as I’m not anemic they don’t check it. I also take my vitamins- 24k of vitamin A, 50k Vitamin D3, and 2 doses daily of calcium hydroxyapatite. Yes, those doses were prescribed-it’s what it takes to keep me at normal levels because I have a malabsorptive disorder. I added lipo- c from Hallandale, and a multivitamin and B-complex. Nothing helped. I ended up switching to Retatrutide because of the extreme fatigue. I lost faster on Tirz, but I’m awake now and food tastes better again. I’m guessing it’s a trade off.. I’m very tempted to go back on Tirz because the weight loss is currently stalled, but the horrible fatigue has me saying no.

I wish I had some advice, but I don’t.