Only done Tirz, flirting with Sema and Reta for reduced sides?

[jafarrr61020]

I've been on tirz for over seven months now, low and slow, and am not totally satisfied with the side effects/intentional effects balance; I've been wondering if one of the other common glp1s would work better for me.
Anyone struggle with bad sleep on tirz, especially low deep sleep, low HRV, high overnight heart rate, and have better luck with another glp? Or anyone struggle with that and shop around but find tirz was actually the best?
Considering switching to sema for a month and seeing what happens, though I hear it's not as good for inflammation which is the main benefit I'm on tirz for (weight loss is a very welcome second). And if that doesn't work, get back to tirz baseline and then give reta a swing for a month, though I expect to not react well to it considering HRV/hr are already problems for me. Open to alternative glps too if there's a magic sleep one!
Appreciate any wisdom or experiences, thanks!

 

[5byfive]

The inflammation effects of Tirz are real. Just did 6 month bloodwork and my CRP dropped by 90%. Side wise, I don't think you are going to do better. Sema is overall just worse sides all around. Reta runs your system harder, so I think you are going to get more not less of the things that are bothering you.

My HRV dropped but mostly recovered by about 4 months in. I found that I needed to eat a smaller meal in the evenings without too many carbs or it tanked my sleep. I think the slower gastric emptying kept my system working harder overnight. I would suggest playing with meal timing snd macros and see if that helps.

 

[lessthanhalf]

Tirz is the glp with the lowest rates of side effects, sema is the worst, with much higher chances of nausea and vomiting fatigue and malaise. Reta is closer to tirz but still has on average more side effects. You could be incredibly lucky and have one of them work better for you than tirz, but not at all likely. Reta has significantly more sympathetic nervous system activation causing increased heart rate compared to tirz. Cannot really suggest better options other than maybe lowering the dose if weight loss is not much of an issue.

 

[jafarrr61020]

The inflammation effects of Tirz are real. Just did 6 month bloodwork and my CRP dropped by 90%. Side wise, I don't think you are going to do better. Sema is overall just worse sides all around. Reta runs your system harder, so I think you are going to get more not less of the things that are bothering you.

My HRV dropped but mostly recovered by about 4 months in. I found that I needed to eat a smaller meal in the evenings without too many carbs or it tanked my sleep. I think the slower gastric emptying kept my system working harder overnight. I would suggest playing with meal timing snd macros and see if that helps.

Nice, I've also had really positive benefits with inflammation! It's the reason I haven't given up. Unfortunately I've tried all the food and lifestyle tweaks I've found suggested and they haven't had any real effect (positive or negative), so my best guess is it's not about blood sugar or digestion for me.

 

[jafarrr61020]

Tirz is the glp with the lowest rates of side effects, sema is the worst, with much higher chances of nausea and vomiting fatigue and malaise. Reta is closer to tirz but still has on average more side effects. You could be incredibly lucky and have one of them work better for you than tirz, but not at all likely. Reta has significantly more sympathetic nervous system activation causing increased heart rate compared to tirz. Cannot really suggest better options other than maybe lowering the dose if weight loss is not much of an issue.

Yeah, that's what I've learned as well. I'm sure twenty years from now we'll all know much more about what factors lead to one or the other being better for each individual, but for now just looking for anecdotes from people with my specific symptoms in hopes I can target my self-experimentation. Unfortunately I need the higher doses for the inflammation control

 

[Grogu]

My sleep is trash, but I’m on 20mg of tirzepatide and .5mg of cagri. I take magnesium glycinate and doxepin at night and that has helped a bit.

Besides the side effects of sema or reta, I would caution folks about “taking a break” on glp-1s. There isn’t a lot of clinical data, but some rat studies and antectdotal accounts suggest that stopping and starting is not the best thing. I’m not aware of any study looking at tirz to sema and back to tirz. I agree with @lessthanhalf that perhaps if weightloss isn’t an issue, to decrease your dose. You might also try splitting your dose. Some people report less side effects when splitting doses. I’ve never done it, but as I’m thinking about it, maybe it would help with my own sleep issues 🤔.

 

[Turbo-Farmer]

Considering switching to sema for a month and seeing what happens, though I hear it's not as good for inflammation which is the main benefit I'm on tirz for (weight loss is a very welcome second). And if that doesn't work, get back to tirz baseline and then give reta a swing for a month, though I expect to not react well to it considering HRV/hr are already problems for me. Open to alternative glps too if there's a magic sleep one!
Appreciate any wisdom or experiences, thanks!

This reminds me of many Reddit threads about side effects.

The dosing schedule for both is on a monthly schedule. Because that’s how long it takes for GLP1s to build up in your body. The half-life on tirzepitide is 5 days, so at 7 days when you take your next dose you have about 40% of the prior dose in your body.

Switching or titrating too fast is a sure way to get side effects.