PE-22-28 acts as a potent inhibitor of the TREK-1 potassium channel (TWIK-related K+ channel 1) in the brain. By blocking this channel, it is thought to promote rapid neurogenesis (the formation of new neurons) and synaptogenesis (the formation of synaptic connections). I’m taking it with epithalon and pinealon as a brain stack. Seems my memory is a little better and my sleep is good but I’m also using DSIP and selank? Will do a two month course of these and wait a week then start a 10 day cerebrolysin load. I’ll the wait a month and do a dihexa 4-6 week load. After the dihexa will wait a few months before repeating. You don’t want to do all of those together as there could be overactivation of neurons leading to badness (hypothetically ) such as headaches, seizures and worse. In theory , I guess over neurogenisis could lead to a brain tumor. That would be deadly. Oh, I do add in a few doses a week of semax.