Peptides for Belly Fat: Which One Works?

[Lucasvinia]

I’ve been using Tirz for almost 3 months now and have already lost around 17 kg (approximately 37.5 lbs) during this period. I still have about 10 kg (approximately 22 lbs) left to reach my goal.

Currently, I’m taking a 10 mg dose, and I’ve noticed excellent appetite suppression. While I’ve lost a lot of inches in my legs, glutes, and arms, I’ve seen very little change in my belly fat so far.

That’s why I’m wondering: has anyone here used any peptide specifically to target belly fat and love handles? If so, could you recommend one for me to look into?

I’m new to this forum and the peptide world, and I’m not very fluent in English. I tried searching the forum for posts related to this topic, but I couldn’t find anything helpful.

 

[Key-Baby314]

Research AOD, Ipamorelin and Tesamorelin. Those are the most common that come up for targettig belly fat.

 

[geoguy78]

Belly fat is gonna be the last thing to go for us guys. What I'm starting to realize is that I've lost a lot of muscle over the years since I left the military and gained weight, so my goal weight is shifting down because I'll probably have to drop more than I originally anticipated to burn the belly. At this point I plan to try and keep dropping until most of my visceral fat appears to be gone. At the same time ramping up my fitness regimen and probably trying Mod GRF/Ipamorelin near goal.

 

[zpped]

I’ve been using Tirz for almost 3 months now and have already lost around 17 kg (approximately 37.5 lbs) during this period. I still have about 10 kg (approximately 22 lbs) left to reach my goal.

Currently, I’m taking a 10 mg dose, and I’ve noticed excellent appetite suppression. While I’ve lost a lot of inches in my legs, glutes, and arms, I’ve seen very little change in my belly fat so far.

That’s why I’m wondering: has anyone here used any peptide specifically to target belly fat and love handles? If so, could you recommend one for me to look into?

I’m new to this forum and the peptide world, and I’m not very fluent in English. I tried searching the forum for posts related to this topic, but I couldn’t find anything helpful.

Tesa has a prescribed usage for lowering belly fat in specific aids patients. People like to associate anything growth hormone related (since tesa is). But we don't really know if they have that specific effect.

The best way to lose belly fat, is to lose fat.

 

[hexagonal]

AFAIK we only have clinical evidence of tesa reducing visceral fat when it comes specifically to belly fat, besides the more general fat loss. If you have a beer gut like I do, there's quite a lot more fat there beyond the stuff packed around your organs, and I don't believe tesa targets it specifically as well. (But from a health perspective visceral fat is the worst kind, so I'm on tesa for it.)

 

[zpped]

AFAIK we only have clinical evidence of tesa reducing visceral fat when it comes specifically to belly fat, besides the more general fat loss. If you have a beer gut like I do, there's quite a lot more fat there beyond the stuff packed around your organs, and I don't believe tesa targets it specifically as well. (But from a health perspective visceral fat is the worst kind, so I'm on tesa for it.)

The tesa trial participants also had abnormal amounts of visceral fat in relation to their overall body fat. It's very reasonable to also conclude tesa just helps you lose fat in general instead of targeting anything.

 

[hexagonal]

The tesa trial participants also had abnormal amounts of visceral fat in relation to their overall body fat. It's very reasonable to also conclude tesa just helps you lose fat in general instead of targeting anything.

Fair.

My next dexa is going to be right when I finish my ipa/tesa stack so I guess I'll be able to directly compare visceral fat lost vs. general fat lost, though I also built out a garage gym and started lifting 5x a week right after the prior dexa, so some confounding factors.

 

[afrayy]

how your body distributes fat is largely, if not 100% genetic. i am skeptical that there is a particular compound that can target fat in a certain area. how would it be able to distinguish?

 

[geoguy78]

how your body distributes fat is largely, if not 100% genetic. i am skeptical that there is a particular compound that can target fat in a certain area. how would it be able to distinguish?

That's kind of my thought on Tesa. It was studied and approved for one medical condition that affects a very specific population: HIV positive individuals with lipidostrophy where a large percentage of their body fat is distributed in their abdomen. But would regular HGH or other HGH secretagogues have done the same for those cases? Maybe Tesa is used because it lacks the full gamut of side effects that straight HGH has? The researchers and pharma company had a reason for pairing Tesa with that specific population, but that doesn't necessarily mean it will have the same effect on your average overweight person. I think a lot of people are throwing Tesa (and a lot of money, it's not cheap) into a stack hoping to get rid of belly fat, when the real answer to losing stubborn belly fat is to just lose more body fat....

 

[AndyPanda]

Belly fat is gonna be the last thing to go for us guys. What I'm starting to realize is that I've lost a lot of muscle over the years since I left the military and gained weight, so my goal weight is shifting down because I'll probably have to drop more than I originally anticipated to burn the belly. At this point I plan to try and keep dropping until most of my visceral fat appears to be gone. At the same time ramping up my fitness regimen and probably trying Mod GRF/Ipamorelin near goal.

Is it just me, or was running in formation with cadence 100x easier than running alone?

 

[geoguy78]

Is it just me, or was running in formation with cadence 100x easier than running alone?

Not sure, but it was definitely easier to run when someone was forcing me to do it! I still call cadence in my head when I run, just habit after 13 years and helps me keep pace

 

[AndyPanda]

Not sure, but it was definitely easier to run when someone was forcing me to do it! I still call cadence in my head when I run, just habit after 13 years and helps me keep pace

I think it helps with breathing properly. Although, when I went through Air Assault school nothing could prepare or save me.

 

[nonyabizznez]

No gut might equal no butt and people pay a premium in the US for your native butt! Before my gut shrank my legs looked like toothpicks and my butt looked like a raisin. Works into my goal of looking like a skinny fat guy though ymmv

 

[hexagonal]

how your body distributes fat is largely, if not 100% genetic. i am skeptical that there is a particular compound that can target fat in a certain area. how would it be able to distinguish?

Well, for the same reason that genetics determine how much visceral fat you're likely to deposit per unit of fat gain - it's down to chemical processes in our body. It's not like tesamorelin directly goes into the fat cells and does the work from my understanding, so perhaps it or GH in general are related to the chemical pathways that determine where fat is deposited.

But a lot of the studies show a reduction in visceral fat with no change to overall weight and body fat %, so it does seem like those are providing evidence that there is some method of action there. (also has shown results in liver fat %)

Effect of Tesamorelin on Liver Fat in HIV

Stanley and coauthors conducted a randomized clinical trial among 50 antiretroviral-treated men and women with human immunodefiency virus infection (HIV) and abdominal fat accumulation to investigate the effect of the growth hormone–releasing hormone analog tesamorelin on visceral adipose tissue...

jamanetwork.com

1499. Tesamorelin Reduces Visceral Adipose Tissue and Liver Fat in INSTI-Treated Persons with HIV

AbstractBackground. Significant attention surrounds the recent observation of weight gain in persons with HIV (PWH) initiating integrase inhibitors (INSTIs

academic.oup.com

Sometimes they even saw an increase in subcutaneous adipose tissue

https://www.nejm.org/doi/full/10.1056/NEJMoa072375#sec-2

 

[zpped]

Is it just me, or was running in formation with cadence 100x easier than running alone?

Yup, There are plenty of reason this is true.

 

[afrayy]

Well, for the same reason that genetics determine how much visceral fat you're likely to deposit per unit of fat gain - it's down to chemical processes in our body. It's not like tesamorelin directly goes into the fat cells and does the work from my understanding, so perhaps it or GH in general are related to the chemical pathways that determine where fat is deposited.

But a lot of the studies show a reduction in visceral fat with no change to overall weight and body fat %, so it does seem like those are providing evidence that there is some method of action there. (also has shown results in liver fat %)

Effect of Tesamorelin on Liver Fat in HIV

Stanley and coauthors conducted a randomized clinical trial among 50 antiretroviral-treated men and women with human immunodefiency virus infection (HIV) and abdominal fat accumulation to investigate the effect of the growth hormone–releasing hormone analog tesamorelin on visceral adipose tissue...

jamanetwork.com

1499. Tesamorelin Reduces Visceral Adipose Tissue and Liver Fat in INSTI-Treated Persons with HIV

AbstractBackground. Significant attention surrounds the recent observation of weight gain in persons with HIV (PWH) initiating integrase inhibitors (INSTIs

academic.oup.com

Sometimes they even saw an increase in subcutaneous adipose tissue

https://www.nejm.org/doi/full/10.1056/NEJMoa072375#sec-2

Interesting point - thanks for the reading!

 

[Blimey]

My thinking is that if Tess worked for those not on specific meds, researchers would have looked into that as there would be money to be made. Something that directly targets belly fat is $$. Has anyone seen a study testing it for efficacy in people non on antiretrovials?

 

[hexagonal]

I've not been able to find any studies for non-HIV patients.

https://pubmed.ncbi.nlm.nih.gov/31237318 the researchers in this study recommended further studies in people without HIV, though, so they at least think it holds some potential.