Peptides for brain health / dementia

[Bsqueezin]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

 

[eidos]

Cyclic Glycine-Proline Improves Memory and Reduces Amyloid Plaque Load in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease

https://pmc.ncbi.nlm.nih.gov/articles/PMC9995210/

One tablespoon of dried blackcurrants per day provides the amount used in the study.

 

[headward]

This might be a good place to start:

My Limitless Stack - Nootropics

I have to admit, I’m only mildly interested in GLP-1s, and I know this forum is primarily dedicated to them. To be fair, I was on Reta for six months and also briefly tried Cagri, but my main area of interest is performance enhancement, particularly nootropics. These are the compounds I’m...

glp1forum.com

 

[rkbleddyn]

Cerebrolysin is the one I keep hearing about. I did find one source for that. I have not tried it myself.

That being said, I do use a peptide to try to increase BDNF and dampen down the stress I have to endure from my high stress job. That peptide is Semax and it does work, for me. It is also supposed to be neuroprotective, as is Selank, which I also use.

Those are the main 3 that I know about.

 

[bada bing]

Not peptides, but preventatives I use:
Omega 3 (fish oil) - get your Omega 3 index tested and maintain it at least 8%, 12% is better
Lithium - low dose OTC supplement
MCT oil - good coffee creamer. The ketones it creates are an alternative brain fuel
Get your APOE4 gene status tested.
And of course, keep your weight down and your HbA1c low. Reta and/or Tirz

I have a family history of dementia, nearly 100%, but all my grandparents, parents, aunts and uncles made it to 85 or later before it showed up. In my family, at least so far, we all live long lives but spend the last 2-5 years out of our friggin minds.

 

[tendency]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

Start with the basics. Have you done baseline bloods?

Without seeing these a good starting point, IMO, would be to microdose Tirz to heal and keep healthy your metabolism.

 

[Goonwise]

https://pmc.ncbi.nlm.nih.gov/articles/PMC9995210/

One tablespoon of dried blackcurrants per day provides the amount used in the study.

Amyloid plaques are not confirmed to be the reason behind Alzheimers or dementia. It seems to be correlated though.

 

[eidos]

Amyloid plaques are not confirmed to be the reason behind Alzheimers or dementia. It seems to be correlated though.

None of this has been elucidated yet.

cGP affects IGF-1 levels (https://www.nature.com/articles/srep04388)
that it is known to activate the insulin receptor.
There are links between Alzheimer's disease and type 2 diabetes (https://pubmed.ncbi.nlm.nih.gov/35269827/)
I'm hypothesis that there's a link on that side.

Another factor that adds to this is how aGLP-1s have a nootropic effect and are being considered as a treatment for Alzheimer's.
I've already mentioned in another thread the cognitive acuity I regained after the first few months of Victoza, and which has remained with Tirz and Reta. (Just old, not completely senile, yet...)

 

[Meritocrat]

1. Cerebrolysin
2. P-21 Adamantane.
3. Adalank- Adamax + Selank
4. Noopept, Citicholine, Modafinil, Irisin.
5. Amylin, PHPD5, FGL, NAP
6. pentapeptide Nle1-YIHP and tetrapeptide Nle1-YIH.
7. SPADIN, DIHEXA, Cholecystokinin Octapeptide (CCK-8), ARA-290, Vesugen, vilon
8. Cortagen, Racetams, Bemethyl, Methylene Blue, 4'-DMA-7,8-DHF (Eutropoflavin), 9-Methyl-β-carboline (9-me-bc), PRL-8-53 (methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate),

 

[coach chickpea]

There are a lot more smart people than me in these forums and I am curious your thoughts on the best peptides for brain health / dementia prevention?

My family is extremely prone to dementia to the point where if you're a male, you are at a 100% chance of getting it later in life. I would love any idea on any peptides that you fine people may know that could help with brain function and/or help prevent dementia. I know there won't be anything that 100% blocks it, but anything that can help slow it down when I get to my older age would be awesome.

Have u looked into selank/semax?

 

[lessthanhalf]

I do not know if there are hereditary syndromes causing dementia that are preventable at this point with conventional medicine, but if risks are that high it might be worth a neurologist opinion. Unless you prefer not to know of course.

GLP peptides have a lot of preclinical data saying they are strongly neuroprotective, but evidence in humans is much weaker and less consistent. It is possible that they need to be started before any substantial damage is done to prevent dementia, but this is far from proven, but much better evidence than other peptides.

One of the enormous problems with Alzheimer's is that of basically all the different treatments tried that work in mice or rat models of the disease, have failed when tested in humans, at least a dozen totally different approaches.