Psoriasis + KPV

[AYarter]

Hey all,

I've has psoriasis my whole life, and tirz is keeping it at bay with the clobetasol cream that had stopped working years ago,. I also have inverse + nail psoriasis and am interested in using KPV to keep it at bay. I was interested in KLOW but I do not have a tolerance for insomnia, as tirz is already wrecking my life with it. I am also interested in TA1.

What are your thoughts on these? Have you used KPV as a lotion or in the more traditional way? What has been your experience?

 

[janedoe]

One of my KPV posts, previously.
Put KPV in the search bar.. tons of info🙂

First KPV experiment

Hi all, For those of you testing KPV, not necessarily KLOW, how long was it before you saw any benefits if any? Have you tried the oral version or the subQ in your research? I'm interested to see if it helps with eczema or immune issues in particular. Just started my experiment and...

glp1forum.com

 

[Chopper]

I have used both Klow and KPV subq and in my experience KPV helps with Skin sensitivity as well as inflammation/pain, but Klow does it slightly better with the exception of the injection site for me.

 

[Hambocommando]

One of my KPV posts, previously.
Put KPV in the search bar.. tons of info🙂

First KPV experiment

Hi all, For those of you testing KPV, not necessarily KLOW, how long was it before you saw any benefits if any? Have you tried the oral version or the subQ in your research? I'm interested to see if it helps with eczema or immune issues in particular. Just started my experiment and...

glp1forum.com

I'm the OP on that post, and I still use KPV subQ to treat my eczema outbreaks and now I use it to mitigate skin sensitivity with Reta. Reta makes my back itch like crazy. I literally just took a shot now because I dosed Reta yesterday and was starting to get itchy. As for psoriasis, I can't speak to it completely.

But as more anecdotal evidence for immune conditions, my mother's dog (yes, actual dog, Labrador) has always had scabby flakey inflamed skin and an inability to have fur on the majority of his body. It's not mange, as near as the vet can tell it is an auto-immune condition based on bad breeding. I do know his full sister has it as well. We started giving Buddy .5mgs of KPV subQ every other day and his skin condition has improved dramatically. Any sores he had have healed really well and quickly, and we've started seeing improvements in the fur department. That's the only change we have made for him. I am a believer. I hope if you try it that you find the relief I have.

 

[AYarter]

I have used both Klow and KPV subq and in my experience KPV helps with Skin sensitivity as well as inflammation/pain, but Klow does it slightly better with the exception of the injection site for me.

I am interested in KLOW but am a little uncertain about TB500 & BPC

 

[ThatNextGril]

I'm the OP on that post, and I still use KPV subQ to treat my eczema outbreaks and now I use it to mitigate skin sensitivity with Reta. Reta makes my back itch like crazy. I literally just took a shot now because I dosed Reta yesterday and was starting to get itchy. As for psoriasis, I can't speak to it completely.

And thank you, btw!
I got bonus adult onset eczema when I hit menopause and thankfully HRT has helped a good deal with it. But, I know the general (anecdotal) feedback on KLOW and KPV is that they are some of the best for skin issues. I've got KPV on the way as I'd like to see if that alone works, as I'd prefer something basic for starters (and I do stack reta and tirz) before I jump into mixed peps, if for nothing else but cost.
Your post is what made me decide to grab the KPV. Obviously N=1 so it may do absolutly nothing for me, but what I love about this forum is that we can all share experiences and "feelz" and keep building our own database of research.

 

[olehandro]

I have psoriasis of the palms. I injected KVP subcutaneously 500mcg per day. Everything got worse. The itching is unbearable. and the redness and peeling got worse.
So after a week I stopped.
Then I tried mixing KVP with my hand cream. (2 mg/2 grams of cream).
this also did not help.
All that helped me improve the situation was an infrared lamp every 2 days. I applied it for 3 minutes.

 

[Hambocommando]

And thank you, btw!
I got bonus adult onset eczema when I hit menopause and thankfully HRT has helped a good deal with it. But, I know the general (anecdotal) feedback on KLOW and KPV is that they are some of the best for skin issues. I've got KPV on the way as I'd like to see if that alone works, as I'd prefer something basic for starters (and I do stack reta and tirz) before I jump into mixed peps, if for nothing else but cost.
Your post is what made me decide to grab the KPV. Obviously N=1 so it may do absolutly nothing for me, but what I love about this forum is that we can all share experiences and "feelz" and keep building our own database of research.

I've started mixing my KPV with BPC 157 because I have all sorts of ligament/ortho injuries as well. I still don't really want to do a KLOW stack because of cost/lack of control on the mix, and I know I have allergy problems with nickel and cobalt and don't want to see if that extends to the copper component. No feelz to report from the bpc 157 yet, but I still rely on the KPV. My eczema is dyshidrotic eczema, which may be different from what you experience so your results may differ. I really hope it gives you some relief, though.

 

[AYarter]

I'm the OP on that post, and I still use KPV subQ to treat my eczema outbreaks and now I use it to mitigate skin sensitivity with Reta. Reta makes my back itch like crazy. I literally just took a shot now because I dosed Reta yesterday and was starting to get itchy. As for psoriasis, I can't speak to it completely.

But as more anecdotal evidence for immune conditions, my mother's dog (yes, actual dog, Labrador) has always had scabby flakey inflamed skin and an inability to have fur on the majority of his body. It's not mange, as near as the vet can tell it is an auto-immune condition based on bad breeding. I do know his full sister has it as well. We started giving Buddy .5mgs of KPV subQ every other day and his skin condition has improved dramatically. Any sores he had have healed really well and quickly, and we've started seeing improvements in the fur department. That's the only change we have made for him. I am a believer. I hope if you try it that you find the relief I have.

TY. I'm going to definitely see what my researcher thinks.

I have psoriasis of the palms. I injected KVP subcutaneously 500mcg per day. Everything got worse. The itching is unbearable. and the redness and peeling got worse.
So after a week I stopped.
Then I tried mixing KVP with my hand cream. (2 mg/2 grams of cream).
this also did not help.
All that helped me improve the situation was an infrared lamp every 2 days. I applied it for 3 minutes.

I've heard of this but everything is so crazy regulated + expensive. What lamp did you use?

 

[olehandro]

TY. I'm going to definitely see what my researcher thinks.

I've heard of this but everything is so crazy regulated + expensive. What lamp did you use?

Hospital Use UVB Phototherapy YK-6000D 311 nm UVB Lamp for Psoriasis Vitiligo Treatment​

 

[vande250]

Welcome! That’s really interesting about your psoriasis improving with tirz — you’re definitely not the only one who’s noticed skin or inflammatory conditions calming down on GLP-1s. There’s growing discussion about their effects on systemic inflammation and immune signaling, so it’s fascinating to hear real-world examples like yours.

KPV is one that comes up fairly often for inflammatory skin issues. Some people experiment with it topically (mixed into a cream/lotion) for localized areas, while others go the subcutaneous route for more systemic anti-inflammatory effects. I’ve seen mixed experiences posted — some people report noticeable improvement in skin irritation or autoimmune-type flareups, while others say it’s more subtle.

TA1 is another interesting one since it’s more about immune modulation, so people sometimes look at it when autoimmune or inflammatory conditions are involved. It seems like one of those compounds people cycle occasionally rather than run continuously.

And I totally hear you on the insomnia piece — GLP-based compounds can definitely mess with sleep for some people, so avoiding anything that might aggravate that makes sense.

Hopefully some others here who’ve specifically used KPV for psoriasis or topical applications can chime in with their experiences. Curious to hear what route you end up trying and how it works for you.

Glad you joined and thanks for bringing up a really interesting topic.

 

[SakeSan]

Glad I saw this post

My RS is on low dose Reta and saw modest impact on scalp psoriasis 3 months in. In 4th month, added klow, went through a vial. Skin got better and saw modest progress again. Started 1mg kpv mixed with 2.5mg GhkCU last 2 weeks and the flares just stopped completely. I’m going to run this for another week before lowering the dose.

Interested in sourcing TA1 as well, trying to find it in a us warehouse

 

[CNCCurrency]

Glad I saw this post

My RS is on low dose Reta and saw modest impact on scalp psoriasis 3 months in. In 4th month, added klow, went through a vial. Skin got better and saw modest progress again. Started 1mg kpv mixed with 2.5mg GhkCU last 2 weeks and the flares just stopped completely. I’m going to run this for another week before lowering the dose.

Interested in sourcing TA1 as well, trying to find it in a us warehouse

Nexaph has kits though his price just increased this week, individual vials are on evolve biopeps for 35

 

[ESSO88]

Interesting. Do you put it down to starting kpv and GhkCU or being on KLOW for some time. I have nail psoriasis, I’m interested in trying something to help

 

[Neurogroot]

Interesting. Do you put it down to starting kpv and GhkCU or being on KLOW for some time. I have nail psoriasis, I’m interested in trying something to help

For nail psoriasis, I imagine KLOW would be your best bet. The copper should help with skin and nails. I am actually considering hopping from subq KPV for my PsA to KLOW since my hair is thinning more than I'd like.

But basically, my experience with KPV... Tirz fixed my skin, so I wanted to fix my joints, which felt slow, and overly dense, and sore. Started KPV, got a mild flare. I didn't panic, I saw that could happen, I stayed the course.

2 weeks later, the flare was gone, and my joints slowly started to improve. 6 weeks later, I feel like my joints are the best they have been in years, maybe 75% of peak joints from what i remember.

Before KPV, I needed to use golf gloves on both hands to swing, thicker ones since the joint strength in my hands wasn't there. Now I can play with just one, standard glove. Again, just my experience. Started with AM/PM dosing 4 days a week (Mon-Thurs), just PM dosing Fri-Sun. Started at 100 mcg AM, 250 mcg PM, but titrated to 200 mcg AM, 450 mcg PM, and 500 mcg on the single dose days.

 

[AYarter]

For nail psoriasis, I imagine KLOW would be your best bet. The copper should help with skin and nails. I am actually considering hopping from subq KPV for my PsA to KLOW since my hair is thinning more than I'd like.

But basically, my experience with KPV... Tirz fixed my skin, so I wanted to fix my joints, which felt slow, and overly dense, and sore. Started KPV, got a mild flare. I didn't panic, I saw that could happen, I stayed the course.

2 weeks later, the flare was gone, and my joints slowly started to improve. 6 weeks later, I feel like my joints are the best they have been in years, maybe 75% of peak joints from what i remember.

Before KPV, I needed to use golf gloves on both hands to swing, thicker ones since the joint strength in my hands wasn't there. Now I can play with just one, standard glove. Again, just my experience. Started with AM/PM dosing 4 days a week (Mon-Thurs), just PM dosing Fri-Sun. Started at 100 mcg AM, 250 mcg PM, but titrated to 200 mcg AM, 450 mcg PM, and 500 mcg on the single dose days.

Amazing. Tirz is helping my skin so much. I am on KLOW now though, but will probably switch it up after this run

 

[Neurogroot]

How long were you on KLOW? Any negatives that you experienced? I’m still on the fence before I spring for a 3 vial trial run. It is dang expensive!

 

[AYarter]

I just ran through my first month and it's been awesome.

 

[WholesomeApril]

I also had psoriasis on my legs and dermatitis in my fingers and after going a couple of cycles of GHK/BPC/TB it went away! I wasn't even using it for that reason so I was so surprised when I woke one day and suddenly noticed it had all cleared.

I haven’t used GHK for about 18 months but I do cycle BPC/TB from time to time when my joints get sore and so far all my skin issues have stayed away.

 

[308fan]

I am using KPV in hopes of my skin clearing and inflammation settling down. I might add KLOW after a month to see any differences. I will report back.

 

[birdwhacker]

We have KPV on the way, I'm hoping it helps my skin issues. Let me know if you hear anything.

Maybe mine is psoriasis? I honestly don't know. My face just gets crusty sometimes and the only thing for it is religious moisturization. Blowdrying and ketoconazole shampoo fixed the problem at the scalp, but my face still gets flaky sometimes.

I really don't like it. It looks very unbecoming and ruins my self esteem when I let it get bad.

 

[SakeSan]

Glad I saw this post

My RS is on low dose Reta and saw modest impact on scalp psoriasis 3 months in. In 4th month, added klow, went through a vial. Skin got better and saw modest progress again. Started 1mg kpv mixed with 2.5mg GhkCU last 2 weeks and the flares just stopped completely. I’m going to run this for another week before lowering the dose.

Interested in sourcing TA1 as well, trying to find it in a us warehouse

Added TA1 and Ss31 for 2 weeks, 1 month ago - no flares since then. Paused all peps except Reta.

AI generated Strategy: Why these two?


• TA1 (Thymosin Alpha-1): This is the "peacekeeper." Psoriasis is a failure of T-regulatory (Treg) cells. TA1 helps the body produce more Tregs, which tell the aggressive T-cells to stop attacking the scalp. This is exactly what she needs to stop the "rebound itch."


• SS-31 (Elamipretide): Even at a low 2mg dose, SS-31 stabilizes the mitochondria in her skin cells. This reduces the "danger signals" (ROS) that keep the immune system in a state of alarm. It also protects her cells from the high metabolic demand of the Retatrutide.

 

[minipepbeast]

I have psoriasis of the palms. I injected KVP subcutaneously 500mcg per day. Everything got worse. The itching is unbearable. and the redness and peeling got worse.
So after a week I stopped.
Then I tried mixing KVP with my hand cream. (2 mg/2 grams of cream).
this also did not help.
All that helped me improve the situation was an infrared lamp every 2 days. I applied it for 3 minutes.

Uv light works wonders for psoriasis! Tanning bed once a week in winter. Lay out by the pool in the summer.

 

[FartfulCodger]

Uv light works wonders for psoriasis! Tanning bed once a week in winter. Lay out by the pool in the summer.

This. And if you don't have access to the sun or a tanning bed, you can get yourself a UV-B light bulb for $10. It's called a lizard light because it's intended for reptile enclosures. Works great for spot-treating. Make sure it's UV-B, not UV-A.