PSP and neurodegenerative disorders

[Blvr7]

Hello! I am looking for help and recommendations for my mother who has a Neurodegenerative disease called progressive supranuclear palsy or PSP. It is a parkinsonism and is caused by a buildup of tau protein on the brain. Its main effects are muscle rigidity, loss of strength and balance, incontinence, bradykinesia, swollowing and voice issues, and frontal lobe shrinking causing memory and cognitive decline. She does NOT need to lose weight. She needs to gain and be able to produce muscle. In my research, only SS – 31 and Pinealon have come up as viable options, and even those dont have many verifiable results in this capacity. I also looked into Cerebrolysin but the lack of human research and the need for intravenous dosage seems impossible. I’m desperate to help her any way I can, but dont have any income to throw at kits as I’m her full time caregiver. I would like to minimize her injection exposure or side effects as much as I can. I would love any input or testimonials from experienced pep folks about what could provide benefits or healing for her.

 

[Smiter]

Hello! I am looking for help and recommendations for my mother who has a Neurodegenerative disease called progressive supranuclear palsy or PSP. It is a parkinsonism and is caused by a buildup of tau protein on the brain. Its main effects are muscle rigidity, loss of strength and balance, incontinence, bradykinesia, swollowing annd voice issues, and frontal lobe shrinking causing memory and cognitive decline. She does NOT need to lose weight. She needs to gain and be able to produce muscle. In my research, only SS – 31 and Pinealon have come up as viable options, and even those dont have many verifiable results in this capacity. I also looked into Cerebrolysin but the lack of human research and the need for intravenous dosage seems impossible. I’m desperate to help her any way I can, but dont have any income to throw at kits as I’m her full time caregiver. I would like to minimize her injection exposure or side effects as much as I can. I would love any input or testimonials from experienced pep folks about what could provide benefits or healing for her.

Have you looked at RI‐AG03, ab76128 blocker peptide (ab211410)?

Creatine, hydrolysed whey, collagen, vitamin C, Niacin.
A student of mine in Canada invented an AI tool to detect parkinson's through voice recognition. I helped him with his research. During that time, we looked into potential avenues for treating symptoms and the use of AI in this regard. In this case, the biggest problem is the obstacle with IV dosage. Now, with adequate muscle protein synthesis nutrition, IGF-1 and myostatin inhibitor could at least reduce the decline in muscle degradation. Also, look at resistance bands, grippers, to incorporate myokines like BDNF production through exercise. This is the reason Cerebrolysin works well. But BDNF and myokines from skeletal muscle has a neurotrophic effect. Yet, these are all mitigators, not resolvers. I'm sorry about your mom, and kudos to you for looking after her. Respect!


,

 

[Blvr7]

Have you looked at RI‐AG03, ab76128 blocker peptide (ab211410)?

Creatine, hydrolysed whey, collagen, vitamin C, Niacin.
A student of mine in Canada invented an AI tool to detect parkinson's through voice recognition. I helped him with his research. During that time, we looked into potential avenues for treating symptoms and the use of AI in this regard. In this case, the biggest problem is the obstacle with IV dosage. Now, with adequate muscle protein synthesis nutrition, IGF-1 and myostatin inhibitor could at least reduce the decline in muscle degradation. Also, look at resistance bands, grippers, to incorporate myokines like BDNF production through exercise. This is the reason Cerebrolysin works well. But BDNF and myokines from skeletal muscle has a neurotrophic effect. Yet, these are all mitigators, not resolvers. I'm sorry about your mom, and kudos to you for looking after her. Respect!


,

Thanks it’s rough. I also have autoimmune issues and dysautonomia so that doesn’t make it any easier.
I haven’t ever heard of that but would love to learn more about it and about what you learned in your research. Is it available anywhere or being studied? I try to keep her active while mitigating her risk of fall and injury, which is constant. Trying to cram enough nutrients and protein into her diet is also challenging.

 

[Smiter]

Trying to cram enough nutrients and protein into her diet is also challenging.

Thats why I mentioned the above ingredients which can be made into a single liquid shake or broth that can be sipped through a straw to minimize swallowing.

I haven’t ever heard of that but would love to learn more about it and about what you learned in your research. Is it available anywhere or being studied?

Yes, those two compounds are available and are being studied. Do a simple google search. I remember these 2 from his research. Medchem express had one of them while the other was some 60 dollars.

I try to keep her active while mitigating her risk of fall and injury, which is constant.

thats why resistance bands are vital. can do them while sitting. Also look for Nikolai Tesla's toe exercises.

 

[Blvr7]

Thats why I mentioned the above ingredients which can be made into a single liquid shake or broth that can be sipped through a straw to minimize swallowing.

Yes, those two compounds are available and are being studied. Do a simple google search. I remember these 2 from his research. Medchem express had one of them while the other was some 60 dollars.

thats why resistance bands are vital. can do them while sitting. Also look for Nikolai Tesla's toe exercises.

Oh we have most of those supplements and alllll the resistance bands and exercise materials. Motivation and apathy are big hallmarks of psp so getting her to do much of anything is a struggle. I mainly focus on water and protein but will try to be better about implementing some of those. I’ll have to look for the toe exercises!
I’m doing some reading and they both sound really interesting, especially riag03 as it precludes the tau from folding instead of just dealing with the aftermath. But I’m not finding much evidence or sources for human consumption. Does that “research” site operate the same way as the grey vendors do? $240 for 1mg seems a little insane. It sounds like the most ideal option yet and I’d love to learn more. I appreciate your input, you clearly have a good understanding of neurodegenerative medicine.

 

[Smiter]

I’ll have to look for the toe exercises

clench toes, hold, release
while sitting, raise heel of feet with toes touching floor, exercising calves. lower, repeat.

Does that “research” site operate the same way as the grey vendors do? $240 for 1mg seems a little insane

I'm sorry, I didnt check providers and their grey status.

Motivation and apathy are big hallmarks of psp so getting her to do much of anything is a struggle

I understand totally.

you clearly have a good understanding of neurodegenerative medicine

I'm a rank amateur

 

[Smiter]

Oh we have most of those supplements and alllll the resistance bands and exercise materials. Motivation and apathy are big hallmarks of psp so getting her to do much of anything is a struggle. I mainly focus on water and protein but will try to be better about implementing some of those. I’ll have to look for the toe exercises!
I’m doing some reading and they both sound really interesting, especially riag03 as it precludes the tau from folding instead of just dealing with the aftermath. But I’m not finding much evidence or sources for human consumption. Does that “research” site operate the same way as the grey vendors do? $240 for 1mg seems a little insane. It sounds like the most ideal option yet and I’d love to learn more. I appreciate your input, you clearly have a good understanding of neurodegenerative medicine.

Also I dont think the most aggressive nootropics would work else I would have mentioned Adamax, Semax, etc. This is from my own notes. I bought all of the following:-
Noopept (omberacetam) is a synthetic nootropic peptide developed in Russia to enhance cognitive function, improve memory, and provide neuroprotective benefits with a higher potency than piracetam. It operates by potentially increasing acetylcholine signaling and brain-derived neurotrophic factor (BDNF/NGF) levels. It is used to improve focus, reduce anxiety, and support recovery from brain injury, often taken in 10-30mg daily doses.

4'-DMA-7,8-DHF (Eutropoflavin) is a synthetic derivative of 7,8-dihydroxyflavone (7,8-DHF) that acts as a potent, brain-penetrating TrkB receptor agonist. It is used as a nootropic to support memory, neurogenesis, and cognitive function, offering stronger and longer-lasting effects than 7,8-DHF. Common dosages include 10mg capsules.

9-Methyl-β-carboline (9-me-bc) is a heterocyclic amine compound acting as a powerful nootropic and neurorestorative agent. It works by inhibiting MAO-A/B, inducing neurite outgrowth, and boosting dopaminergic neurons in the brain, suggesting potential benefits for dopamine restoration, cognitive enhancement, and neuroprotection.

PRL-8-53 (methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is an synthetic nootropic research compound known for potential memory-enhancing effects, specifically improving verbal retention in studies. Developed by Dr. Nikolaus Hansl in the 1970s, it is a phenethylamine derivative researched for cognitive enhancement, but it has not been approved for human use by the FDA.

Bemethyl (2-(ethylthio)-1H-benzimidazole) is a Soviet-developed actoprotector, antihypoxant, and mild psychostimulant used to increase physical endurance, improve mental work capacity, and enhance resistance to hypoxia and stress. Originally designed for cosmonauts and soldiers, it activates RNA/protein synthesis to improve metabolic efficiency.

Methylene blue is a synthetic dye with FDA-approved use for treating methemoglobinemia (a rare blood oxygen disorder) and as a diagnostic stain. It acts as a redox agent to restore oxygen delivery. While sometimes used off-label for cognitive enhancement and energy, it poses risks of serotonin syndrome if combined with antidepressants due to its MAOI properties, making medical supervision essential. Cognitive Enhancement: Studied for improved memory and focus.

• Mitochondrial Support: Believed to boost cellular energy production and reduce fatigue.
• Neuroprotection: Explored in research for potential neuroprotective effects

 

[Blvr7]

Thank you! Have you had noticeable results? She can’t take pills and is currently on a liquid sertraline ssri. Both methylene blue and 9-me-BC are MAO inhibitors and Methylene blue combined with sertraline is an FDA documented contraindication with at least one fatal case report. 9-me-BC's MAO-A inhibition at IC50 of 1μM creates the same serotonin syndrome risk. Unfortunately, both are eliminated by her current medication regardless of their neuroprotective merit, unless they provide more benefits and I remove the sertraline.

Given that the two most mechanistically relevant compounds are eliminated by the sertraline interaction, do you have thoughts on alternatives that address the same dopaminergic and tau aggregation pathways without MAO inhibition? Or would integrating some of your other suggestions be beneficial? No idea where to get those either. It seems that RI-AG03 which targets 4R tau hotspots directly without any serotonergic mechanism would be really useful- if I could figure out where to obtain it.
Are you aware of the UCSF platform trial evaluating AADvac1 and AZP2006? Would love to try that as well, if I could find it.

As far as peptides go, I’m still left with ss-31 and pinealon being the most appropriate for her to try, even though they only work downstream of the tau buildup.
I appreciate your continued advice. It’s all very overwhelming.

 

[Smiter]

Are you aware of the UCSF platform trial evaluating AADvac1 and AZP2006?

No, m sorry. Yes, if she is on an SSRI then MAO inhibitors are out. Yes, they do work mildly. I use modafinil too. Then I use the 2 items in the pics

 

[Smiter]

Thank you! Have you had noticeable results? She can’t take pills and is currently on a liquid sertraline ssri. Both methylene blue and 9-me-BC are MAO inhibitors and Methylene blue combined with sertraline is an FDA documented contraindication with at least one fatal case report. 9-me-BC's MAO-A inhibition at IC50 of 1μM creates the same serotonin syndrome risk. Unfortunately, both are eliminated by her current medication regardless of their neuroprotective merit, unless they provide more benefits and I remove the sertraline.

Given that the two most mechanistically relevant compounds are eliminated by the sertraline interaction, do you have thoughts on alternatives that address the same dopaminergic and tau aggregation pathways without MAO inhibition? Or would integrating some of your other suggestions be beneficial? No idea where to get those either. It seems that RI-AG03 which targets 4R tau hotspots directly without any serotonergic mechanism would be really useful- if I could figure out where to obtain it.
Are you aware of the UCSF platform trial evaluating AADvac1 and AZP2006? Would love to try that as well, if I could find it.

As far as peptides go, I’m still left with ss-31 and pinealon being the most appropriate for her to try, even though they only work downstream of the tau buildup.
I appreciate your continued advice. It’s all very overwhelming.

also, what about Adamax, Semax, and Selank?

 

[Blvr7]

also, what about Adamax, Semax, and Selank?

I don’t know anything about adamax. I was recommended selank for caregiver stress so was planning on doing that intranasally, which I can also give her. I’d be open to adding semax but I’m not sure of the real benefits considering the antidepressants we are already on. Primarily, they don’t really focus on the core issues of PSP and the most intense symptoms. Was hoping for more of the riag03 type targets. Do you know anything else regarding the results or ongoing use of that for neurological disorders?