Reaction-Led Dosing Schedule?

[EXTRA TERRESTRIAL]

So I think most of us dose as recommended - by the calendar weekly, or twice a week by splitting doses.

I was wondering if anyone had tried ignoring 'time since last dose' and simply injecting when they feel like they could benefit from the effects of the reta.

As I switch from tirz, I'm considering taking a small dose of 0.5mg whenever I feel like I'm no longer benefitting from my last dose.


I think this could have some pros:-

• Instead of guesstimating equivalent doses, I'm assuming my average reta dose will 'settle' at where my body needs it.
• I can be more reactive to potential side-effects.

Cons:-

-I guess it could put me at risk of dosing too high, but hopefully the small starting dose would mitigate that risk.


Are there any risks with this approach that I'm missing? I'm hesitant to receive a new medication and start injecting 2+mg just because I have prior experience with another GLP-1, so any advice would be appreciated.

 

[PopTart]

Are there any risks with this approach that I'm missing?

There are no clinical trials for stacking tirz with reta so that is a risk. There’s a reason why reta targets the 3 receptors in the ratio and to the magnitude that they do. IMO, stacking both and creating an unstudied ratio based on “feels” is unscientific. Plenty of people stack both but their experiences are purely anecdotal.

Are you at the max dose of tirz and it is no longer working? Have you tried pinning tirz every 5 days?

If you end up running an irregular dosing schedule, you may want to consider a tracking app such as Shotsy which will give you a better idea of how much of the pep is in your bloodstream - it won’t give you an exact number but it will be better than skydiving without a parachute.

 

[lessthanhalf]

I am not in general recommending this strategy, but I have good medical knowledge so can use this to reduce chances of problems for myself. I used a strategy similar to this to start tirzepatide and built up the dose over about 6 weeks to 15mg/w. I had been using semaglutide every second day to minimise nausea, so when I switched, I kept going with every second day with tiz, and just added an extra mg every second day then 2mg every second day and slowly built up, depending on whether it was making me nauseous or hungry. You really need small frequent doses for this to work, and use the https://glp1plotter.com/ website to work out what blood levels result from what doses and when. It is important to understand both absorption and elimination half lives to do this, as these drugs are very different to nearly everything else, taking for retatrutide 8 to 48 hours for maximum levels after a dose, and then an average of 6 days to reduce to half that level.
Maximum dosing frequency would be second daily due to the slow absorption of each dose, and if you use the glp plotter you will see that blood levels continue to rise for weeks after a dose increase. So there is a bit to keep track of to use this strategy, and it is definitely safer and easier to use the recommended dosing. If you mess up with small frequent doses and get horrible side effects in theory it should only take 2 or 3 days to go back to the blood level you were at before. The biggest common risk of these medications is of getting horrible nausea and vomiting or diarrhoea that leaves you dehydrated and needing a trip to hospital. Anything other than the slow recommended dosing is a bad idea if you have diabetes or have significant medical issues, as this amplifies the risk from dehydration due to adverse effects.