Reta and mood improve

dandam

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Does anyone have something to recommend to improve mood while on reta?
 
I started on Tirz and added Reta for the energy and additional fat mobilization effects, and actually noticed a slight mood boost just from that. But I am taking fairly low doses of both, 2.5mg tirz and 1mg reta. Maybe I will experience the additional flatness as I move up in dose. I will probably look into Semax for that.
 
So I have definitely noticed what you’re talking about. For me it’s more of an “edginess.” My fuse is really, really short. Which is brutal with 3 young kids.

I tried NA Semax (IN) and didn’t really notice much of anything. Gave it 5-weeks, daily about 400-800mcg/day.

NAD+ I get buffered bc that shiz made my leg twitch on the 2nd pin…buffered is much less spicy. I like how it interacts with the Reta, may just be placebo, but the NAD+ injection days are just better as far as cleaner energy, stamina I would say?

But the BEST thing I’ve found on Reta in the past 5-6 weeks is what I now force myself to eat.

I prioritize good carbs and “clean” sugars…
Basically I was exhausted and miserable all the time because my body needed more carbs, which I have learned to hate ever since doing Keto a few years back.

I know people say food noise isn’t gone on Reta…well it is for me.

It is so obvious when it kicks in. I take about 2.4mg Tuesday and 2.4mg Friday. When I take it in the mornings…by night my appetite is curbed. By morning food noise is gone completely. All that to say I’ve felt comfortable with my lower effective doses, and feel like my body has responded really well except the agitation.

When food noise is gone is when I have to force myself carbs. I lost weight faster and feel so much better when my diet is just functioning (shocker).

TL😀R
NAD+ (buffered if you’re a baby like me) helped energy which in turn helped my mood // 250mg 3x/wk

Tried NA Semax (Intranasal) with no luck.

Good carbs in the mornings and day changed my mood and energy levels overnight.

Hope you find something that works!
 
Itsjacob said:
So I have definitely noticed what you’re talking about. For me it’s more of an “edginess.” My fuse is really, really short. Which is brutal with 3 young kids.

I tried NA Semax (IN) and didn’t really notice much of anything. Gave it 5-weeks, daily about 400-800mcg/day.

NAD+ I get buffered bc that shiz made my leg twitch on the 2nd pin…buffered is much less spicy. I like how it interacts with the Reta, may just be placebo, but the NAD+ injection days are just better as far as cleaner energy, stamina I would say?

But the BEST thing I’ve found on Reta in the past 5-6 weeks is what I now force myself to eat.

I prioritize good carbs and “clean” sugars…
Basically I was exhausted and miserable all the time because my body needed more carbs, which I have learned to hate ever since doing Keto a few years back.

I know people say food noise isn’t gone on Reta…well it is for me.

It is so obvious when it kicks in. I take about 2.4mg Tuesday and 2.4mg Friday. When I take it in the mornings…by night my appetite is curbed. By morning food noise is gone completely. All that to say I’ve felt comfortable with my lower effective doses, and feel like my body has responded really well except the agitation.

When food noise is gone is when I have to force myself carbs. I lost weight faster and feel so much better when my diet is just functioning (shocker).

TL😀R
NAD+ (buffered if you’re a baby like me) helped energy which in turn helped my mood // 250mg 3x/wk

Tried NA Semax (Intranasal) with no luck.

Good carbs in the mornings and day changed my mood and energy levels overnight.

Hope you find something that works!
Click to expand...
This is just some info I found, actually the best info I could find because every medical website I found suggests that the drug does not cause this problem directly. And yes, we all react differently to it.

I googled it because I am aware that I have a short-fuse, but it's from Tren (Trenbolone Enanthate). I added it to my TRT at only 25mg /wk, which is an extremely low does, but I feel it has changed me and I have to be constantly aware of it.

I hope this can help:

  • Yes, some patients report irritability while using GLP-1 medications
  • No, this is not common and not clearly a direct drug effect
  • Most cases are related to under-fueling, blood sugar changes, sleep disruption, or reward pathway shifts
With proper guidance and monitoring, GLP-1 medications remain safe and effective for most people. If mood changes occur, they deserve attention—not panic, but thoughtful evaluation.
 
JokeyJo said:
I’m stopping all GLPs due to the anhedonia sadly.
Click to expand...
I'm sorry to hear 🙁

Mine is nowhere near as crucial, but at least now I understand why I lost the interest and joy from my morning coffee. I stopped drinking coffee for 2 months. I only just started again 2 weeks ago.

And a real silly thing.....I cried at the end of a movie, "The Accountant"
- my 5th time watching it.
 
maven8518 said:
What mg did you start to notice it?
Click to expand...
1mg!!! However - I know for a fact I’m extremely sensitive to GLPs. A starter dose of Sema nearly got me hospitalised for dehydration. Tirz worked wonders in terms of weight loss and even after six months of going up slowly I only needed a starter dose for weight loss.
The downside is that I’m also very sensitive to the side effects, it seems. And no, I’m not in general very sensitive to meds or anything - it’s just GLPs. 😩
 
Hi! It’s me! A person with chronic treatment resistant depression. I find that if you deliberately look for things that bring joy it helps. This is a long term mindset.

Stuff that works for me:

Singing. I always sing when I’m sad and it makes me feel better. Any sort of self expressing is good for this.

Hanging out with my dog. She’s the best. We go out and do stuff together like get ice cream or walk on trails or go to the lake. sometimes I go to the dog park just to pet dogs.

Going for a walk.

Getting good sleep, and allowing myself to sleep if I need it.

Binge watching a show.

Playing video games.

Getting out on water, like canoeing or kayaking or jumping on a boat.

Doing something for self care. Maybe a wellness spa? Hot bath followed by cold plunge and then a rest station will uplift you in some sort of way.

Going to see live music.

YMMV but the choice here is to choose experience and expression over trying to find a substance. I’ve had this beast for 25 years and imo this is the only way to fight it.
 
JokeyJo said:
I’m stopping all GLPs due to the anhedonia sadly.
Click to expand...
I have wondered about this. I feel for you.
WeirdPinkPiLL said:
Hi! It’s me! A person with chronic treatment resistant depression. I find that if you deliberately look for things that bring joy it helps. This is a long term mindset.

Stuff that works for me:

Singing. I always sing when I’m sad and it makes me feel better. Any sort of self expressing is good for this.

Hanging out with my dog. She’s the best. We go out and do stuff together like get ice cream or walk on trails or go to the lake. sometimes I go to the dog park just to pet dogs.

Going for a walk.

Getting good sleep, and allowing myself to sleep if I need it.

Binge watching a show.

Playing video games.

Getting out on water, like canoeing or kayaking or jumping on a boat.

Doing something for self care. Maybe a wellness spa? Hot bath followed by cold plunge and then a rest station will uplift you in some sort of way.

Going to see live music.

YMMV but the choice here is to choose experience and expression over trying to find a substance. I’ve had this beast for 25 years and imo this is the only way to fight it.
Click to expand...
Hello, from another treatment resistant depressive.
I’ve noticed that I’m not sad.. I just have lost the impetus to do things. It drives me crazy, but apparently not crazy enough to get my butt going to complete things that I need to do. I’ve tried 5-amino, methylene blue, increasing my ADD meds, increasing my antidepressant.. fixing to break down and talk to my psychiatrist about it. Granted, I’ve dealt with some hard things in the past 4 years (lost all of my geriatric pets, one a year; laid off from my job; lost my much-adored nephew to drugs- for a while there I was a functional zombie. I did what I had to do and that was it. And I’ve been told “it’s just an animal” more than once, but I had one for 20 years and one for 13 years- it was like losing a child. My nephew’s death nearly tore his family apart- one of his sisters went out of her way to torch every family relationship she had, his other sister and his dad decided to sell a family business that has been in existence and built from nothing to a thriving multimillion dollar business over 60 years because dad was destroyed by losing him and his sister doesn’t want to run the business alone (the youngest was never involved in the business other than minimally). It closed its doors April 30th. I was told by the youngest that I had no right to grieve him because I wasn’t immediate family (she’s a gem, that one) and I only commented to steal sympathy from her when she posted on social media… 🙄 so my grieving was complicated. And yes, even with his issues, he was a very loved and loving young man. He was very unique in that he made a point of being there when people needed him, not just for his family, but to friends and acquaintances as well. He was the popular kid who showed up at less popular kid’s parties and stayed. The one that visited his friend’s aunt who had terminal cancer both at home and in the hospital. He loved being an uncle and was Santa Clause and the Easter bunny and loved doing it every year. He took his mom out on Valentine’s Day every year and sent me flowers all the time for no reason because he knew I loved them. He left a huge hole in a lot of lives.
Anyway.. got distracted. Yeah, going to talk to my psychiatrist because I’m not suicidal- I just have to force myself to do what I need to do to live my best life. It sucks, and I don’t know if it’s the GLPs or a combo pack of life and GLPs.
FarmgirlRebel said:
I've been getting a big boost with Methylene Blue
Click to expand...
It helps me when I can’t focus. But no extra energy.
 
FlowerFairy said:
Granted, I’ve dealt with some hard things in the past 4 years
Click to expand...
OMG! You have experienced way more than just "some hard things"!
What you have been through is enough to get any healthy person depressed or ill! You seem to have amazing resilience to be coping as well as you seem to be.

And yeah, GLP anhedonia doesn't help!

I didn''t recall the name of it, but there is a stress scale, (I looked it up) --The Holmes-Rahe Life Stress Inventory, which is a tool designed to measure the amount of stress a person is experiencing based on recent life events.

It lists various life events -- such as the death of a loved one, divorce, job loss, or personal injury -- the score can suggest a greater risk of health problems, including illness or emotional disturbances, due to accumulated stress. You can tinker with it here --

www.stress.org

Holmes-Rahe Life Stress Inventory - The American Institute of Stress

The place to start is to find out how stressed you are and more importantly, how you are effected by stress. This tool assigns point values to various life events quantifying stress levels. Individuals can calculate their overall stress score, offering insights into their potential risk for...
www.stress.org www.stress.org

And, yeah, if you have access to a psychiatrist or therapist, by all means this is a good time to check in.
 
FlowerFairy said:
I have wondered about this. I feel for you.

Hello, from another treatment resistant depressive.
I’ve noticed that I’m not sad.. I just have lost the impetus to do things. It drives me crazy, but apparently not crazy enough to get my butt going to complete things that I need to do. I’ve tried 5-amino, methylene blue, increasing my ADD meds, increasing my antidepressant.. fixing to break down and talk to my psychiatrist about it. Granted, I’ve dealt with some hard things in the past 4 years (lost all of my geriatric pets, one a year; laid off from my job; lost my much-adored nephew to drugs- for a while there I was a functional zombie. I did what I had to do and that was it. And I’ve been told “it’s just an animal” more than once, but I had one for 20 years and one for 13 years- it was like losing a child. My nephew’s death nearly tore his family apart- one of his sisters went out of her way to torch every family relationship she had, his other sister and his dad decided to sell a family business that has been in existence and built from nothing to a thriving multimillion dollar business over 60 years because dad was destroyed by losing him and his sister doesn’t want to run the business alone (the youngest was never involved in the business other than minimally). It closed its doors April 30th. I was told by the youngest that I had no right to grieve him because I wasn’t immediate family (she’s a gem, that one) and I only commented to steal sympathy from her when she posted on social media… 🙄 so my grieving was complicated. And yes, even with his issues, he was a very loved and loving young man. He was very unique in that he made a point of being there when people needed him, not just for his family, but to friends and acquaintances as well. He was the popular kid who showed up at less popular kid’s parties and stayed. The one that visited his friend’s aunt who had terminal cancer both at home and in the hospital. He loved being an uncle and was Santa Clause and the Easter bunny and loved doing it every year. He took his mom out on Valentine’s Day every year and sent me flowers all the time for no reason because he knew I loved them. He left a huge hole in a lot of lives.
Anyway.. got distracted. Yeah, going to talk to my psychiatrist because I’m not suicidal- I just have to force myself to do what I need to do to live my best life. It sucks, and I don’t know if it’s the GLPs or a combo pack of life and GLPs.

It helps me when I can’t focus. But no extra energy.
Click to expand...

Consider that is SO REASONABLE to feel sad over devastating losses like that.

I lost my father and my dog within three months of each other in 2024 and boy…

What I’ve learned with the depression beast is that identifying when I’m sad for no reason, and also when I am sad for a reason that is normal to sad in, is really helpful for me to regulate my feelings.
 
Itsjacob said:
So I have definitely noticed what you’re talking about. For me it’s more of an “edginess.” My fuse is really, really short. Which is brutal with 3 young kids.

I tried NA Semax (IN) and didn’t really notice much of anything. Gave it 5-weeks, daily about 400-800mcg/day.

NAD+ I get buffered bc that shiz made my leg twitch on the 2nd pin…buffered is much less spicy. I like how it interacts with the Reta, may just be placebo, but the NAD+ injection days are just better as far as cleaner energy, stamina I would say?

But the BEST thing I’ve found on Reta in the past 5-6 weeks is what I now force myself to eat.

I prioritize good carbs and “clean” sugars…
Basically I was exhausted and miserable all the time because my body needed more carbs, which I have learned to hate ever since doing Keto a few years back.

I know people say food noise isn’t gone on Reta…well it is for me.

It is so obvious when it kicks in. I take about 2.4mg Tuesday and 2.4mg Friday. When I take it in the mornings…by night my appetite is curbed. By morning food noise is gone completely. All that to say I’ve felt comfortable with my lower effective doses, and feel like my body has responded really well except the agitation.

When food noise is gone is when I have to force myself carbs. I lost weight faster and feel so much better when my diet is just functioning (shocker).

TL😀R
NAD+ (buffered if you’re a baby like me) helped energy which in turn helped my mood // 250mg 3x/wk

Tried NA Semax (Intranasal) with no luck.

Good carbs in the mornings and day changed my mood and energy levels overnight.

Hope you find something that works!
Click to expand...
May I ask where you found buffered NAD? Im currently using unbuffered NAD and it is not the vibe.
 
FlowerFairy said:
Hello, from another treatment resistant depressive.
I’ve noticed that I’m not sad.. I just have lost the impetus to do things.
Click to expand...
personally, I am very resistant to depression, but holy shyte, if there's anybody who has got just cause... To be honest, imho, I would consider that lost impetus to do things a far more dangerous issue. I find that human beings require a sense of purpose in their lives. I do tend to lose sight of my own. Fortunately it's temporary.

dandam said:
Does anyone have something to recommend to improve mood while on reta?
Click to expand...
I would begin by comprehending that 'mood' itself is a chemical reaction. Then I would think that if it can work one way, then there must be a resolution to get it fixed. I was talking to Charliebrown here yesterday about Sameday Supplements. Ingredients like GABA, L-Theanine, Bacopa, etc. could work. I personally find Bemethyl-Methylene Blue-Modafinil to be a great mood changer. There's a product called Euphoria made by blackstone. You could check the list of ingredients there. In other forums I go to, some acquaintances swear by it. I'm considering buying it myself because I'm using Reta now.

For the rest, I do not know your gender so I can't be precise. I would point out Weird pink pill's post above. It's very illuminating. You need to deliberately choose activities that would be pleasing to you even if it doesn't feel like it. It's the dopamine that you need to target. Most of the activities that Weirdpink listed are excellent options for women. For us men, things are a little different. We derive the same psychological benefit from slightly different activities. It's about the esteem/actualization needs. The only point of disagreement I have is the following:
WeirdPinkPiLL said:
trying to find a substance
Click to expand...
As an amateur biohacker, I recognize that whichever way we cut it, we ARE a bunch of chemicals. Our environment is filled with chemicals capable of altering our functioning. I wouldn't find anything wrong with us using aids ourselves to better our functioning.
 
Itsjacob said:
So I have definitely noticed what you’re talking about. For me it’s more of an “edginess.” My fuse is really, really short. Which is brutal with 3 young kids.
Click to expand...
I read this, then looked at your profile picture and it fits perfectly 😆
 
JokeyJo said:
I’m stopping all GLPs due to the anhedonia sadly.
Click to expand...
I stopped for the same reason, I have been off 4 weeks and have started feeling like myself again. I am going to give it another run in a few weeks, I am hoping to avoid the anhedonia. I took Reta for about 6 weeks before the anhedonia started.
 
CharlieBrown said:
I'm sorry to hear 🙁

Mine is nowhere near as crucial, but at least now I understand why I lost the interest and joy from my morning coffee. I stopped drinking coffee for 2 months. I only just started again 2 weeks ago.

And a real silly thing.....I cried at the end of a movie, "The Accountant"
- my 5th time watching it.
Click to expand...
"I cried at the end of a movie" Bro thats your E2 getting high.
 
Vriende said:
OMG! You have experienced way more than just "some hard things"!
What you have been through is enough to get any healthy person depressed or ill! You seem to have amazing resilience to be coping as well as you seem to be.

And yeah, GLP anhedonia doesn't help!

I didn''t recall the name of it, but there is a stress scale, (I looked it up) --The Holmes-Rahe Life Stress Inventory, which is a tool designed to measure the amount of stress a person is experiencing based on recent life events.

It lists various life events -- such as the death of a loved one, divorce, job loss, or personal injury -- the score can suggest a greater risk of health problems, including illness or emotional disturbances, due to accumulated stress. You can tinker with it here --

www.stress.org

Holmes-Rahe Life Stress Inventory - The American Institute of Stress

The place to start is to find out how stressed you are and more importantly, how you are effected by stress. This tool assigns point values to various life events quantifying stress levels. Individuals can calculate their overall stress score, offering insights into their potential risk for...
www.stress.org www.stress.org

And, yeah, if you have access to a psychiatrist or therapist, by all means this is a good time to check in.
Click to expand...
I was seeing a therapist BEFORE my nephew died. In fact, he was seeing me, my sister, my nephew and my youngest niece. It only took him 2 months to realize I was related to the other folks in my family, even though I had talked about my sister, my nephew and nieces and my sister talked about me and her kids. With the new job I had to change psychiatrists.

It is getting better, but for 3 years I did nothing but what I absolutely had to do. Now I’m trying to dig out from just dropping everything and not dealing with it. It’s a bit overwhelming.
 
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