Reta and short breaks

[rpadevman]

My girlfriend and I have been on Reta for almost 3 months. We recently bumped it up to 4mg (last pinned 5 days ago). Now we have a 7 night cruise starting in 1 week, and we were thinking about not pinning again until after the cruise. After all, the free all you can eat is quite a main benefit of cruising! 😂

Anyway, has anyone taken a similar break? Do you think 12 days is enough to get our appetite back, and when we get back is it probably fine to just pick up at the same dose we were at before?

 

[woundcarping]

There’s no way I would skip two weeks just so I could eat more on a cruise.

I went to Orlando and Vegas in March, dosed regularly and came back lighter than when I left. Next weekend I’m headed east for a week, I’ll dose regularly then as well.

 

[HRH_IceQueen]

I'm in a similar predicament, I was on Reta at 4mg/wk, but split pinning to 2mg every 3.5 days. I have a procedure coming up that I have to stop all peps for 8 to 14 days prior. After that I'm traveling out of the country for about 2 weeks, so I'm planning to take a break for a month and start my Reta at 1mg for a week and titrate up every 2 weeks or depending on how my body respond to it until I'm where I was before.

 

[rpadevman]

There’s no way I would skip two weeks just so I could eat more on a cruise.

I went to Orlando and Vegas in March, dosed regularly and came back lighter than when I left. Next weekend I’m headed east for a week, I’ll dose regularly then as well.

Is there a particular reason or personal preference? Primarily I’m mostly concerned about health concerns and how to restart the dose. We have the drink package, so although I’m not planning on getting plastered, this is new territory for me.

 

[Mochizuki0124]

My personal opinion is that if you're taking reta more often than not you are trying to fix a eating habit that caused you to gain weight. Stopping it for the purpose of eating a lot kinda defeats the purpose.

Imo just lower your dose during the cruise and don't let yourself ruin months of work in 12 days.

 

[woundcarping]

Is there a particular reason or personal preference? Primarily I’m mostly concerned about health concerns and how to restart the dose. We have the drink package, so although I’m not planning on getting plastered, this is new territory for me.

Stopping and Restarting Certain GLP-1s to Lose Weight May Make the Drug Less Effective

Not that I'm looking at start another thread about the pros and cons of lifetime glp-1 use, since I think we've recently beaten that horse dead. But this article is a somewhat different twist and talks about cycling glp-1s and the potential for reduced effectiveness when cycling over staying on...

glp1forum.com

Penn Researchers: GLP-1 Medications and the Stop-Start Problem: New Research on Therapeutic Resistance

New research suggests that cycling on and off GLP-1 medications like semaglutide may cause therapeutic resistance — leaving patients potentially more obese than those who stayed on the drug continuously.

weightcontrol.com

Repeated Withdrawal of a GLPR Agonist Induces Hyperleptinemia and Deteriorates Metabolic Health in Obese Aging UM‐HET3 Mice - PMC

GLP‐1‐based therapy is highly effective in combating aging‐associated metabolic diseases. However, the metabolic effects of frequent withdrawal from this therapy in aged, obese mice have not been previously studied. In this study, aged obese UM‐HET3 ...

pmc.ncbi.nlm.nih.gov

Cycling resulting in reduced efficacy/potential is something I'd expressly like to avoid.

My personal opinion is that if you're taking reta more often than not you are trying to fix an eating habit that caused you to gain weight. Stopping it for the purpose of eating a lot kinda defeats the purpose.

This, but more strongly worded, was my initial thought for a response.