Reta w/ Hypoglycemia?

Dos-Dox

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Oct 31, 2025
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Does anyone have any experience with reta hypoglycemia? I have a family member (F73) wanting to start retatrutide but she suffers from hypoglycemic episodes. (She is not diabetic, doesn’t drink, etc.) I just want to ensure the risks associated with reta usage aren’t of more concern for her with this condition.

I’ve read every thread on this forum that mentions hypoglycemia but don’t see anything about someone already having recurrent hypoglycemia before starting reta. I haven’t found much out on the web in my searches either.

I’ve seen that GLP1s can exasperate hypoglycemia, but that the risk is lower with reta due to the glucagon receptor targeting. My thought is that hypoglycemia is another form of metabolic disorder, which reta should help stabilize. If she sticks with a low dose, eats small meals throughout the day (even if not particularly hungry) and monitors blood sugar, she should be able to give it a go to see how well it is tolerated. Does this logic seem reasonable? I’d appreciate any thoughts or experience you have with this combo. Thank you.
 
I took reta for two months, and the only hypyoglycenic episodes I have ever had was while taking the reta. However, I wasn't eating frequent small meals, I was skipping breakfast, eating a small dinner and small lunch.

I have a Dexcom, a couple of times my glucose level got down into the fifties. Since she is better at taking care to eat properly throughout the day and monitors her levels, she might do okay. My thought would be to start low and slow. I admit I went up pretty quickly and didn't start low.
 
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