Retatrutide plateau / Adaptation or resistance to reta

[Zydeceltico]

I certainly wish I had started on therapies to reduce cardiovascular risk a decade earlier at your age, before damage was done, rather than after.

Ditto ...... there is no "soon enough."

 

[Tibial]

Of course, another add-on people try are the GH secretagogues, like tesamorelin (tesa) for visceral fat loss. I haven't taken them long enough to notice any fat loss, but I like them for recovery. Though there can be more risk with them, Dr. Seeds is a fan. I fast for doing those (before and after) and take twice a day, so that routine helps with me doing some intermittent fasting.

More controversially, @DwightTheDelight once reminded me that the focus on protein in the peptide community can lead to weight gain (at least with fatty protein sources) since starches, beans, and lentils generally have a higher satiety per calorie than animal protein:

High-Dose Tirz Weight Loss

I just hit overweight on the BMI scale and figured it would be a good time to post an update, since I'm not sure how many other people are above the 15mg/week threshold and it might be useful info to some. My doctor recently told me I need to start wrapping this up and slowing down. High dose...

glp1forum.com

Do people really do this? I tried mk677 before and holy shit I could eat a dinner for a family of 4 after that, it made my appetite go insane. Is it not this way with other secretagogues?

 

[Calm Logic]

Do people really do this? I tried mk677 before and holy shit I could eat a dinner for a family of 4 after that, it made my appetite go insane. Is it not this way with other secretagogues?

One of them (GHRP-2) can really increase appetite but not the more popular ones like tesa:

Like its cousin GHRP-6, GHRP-2 strongly mimics ghrelin (the hunger hormone). Unlike GHRP-2, Tesamorelin is a GHRH analog (Growth Hormone Releasing Hormone), not a ghrelin mimetic.

I put a table here:

Is anyone else hungry all the time on tesa and ipa?

I see it’s a “less common” side effect so I’m curious how prevalent it is

glp1forum.com

If anything, I have been able to eat less on hex and HGH, just from being motivated to fast around them. I was stuck at 200 pounds for months (since I avoid higher doses of GLPs due to sides), but now the weight is going down again. Years ago without GLPs, intermittent fasting (even for just 12 hours, as now) is one way I would lose weight (before gaining it back).

 

[CNCCurrency]

This is the same issue I’m feeling. Did you notice anything at 3 mg? I started on 2mg for the last 4 weeks and am going to bump up to 3mg on Monday. Hope it works

Unless you're a super responder, I thought they were dose dependent, meaning higher does equal greater weight loss? Why not follow the drug company protocol and double your dose every 4 weeks? The studies show proven results.

 

[Quatroskin]

Unless you're a super responder, I thought they were dose dependent, meaning higher does equal greater weight loss? Why not follow the drug company protocol and double your dose every 4 weeks? The studies show proven results.

I started by following the studies at 2mg and truthfully it hit me like a ton of bricks. No appetite, sleep was awful, constipation. But the last week and a half I feel the food noise coming back so I’m just going to bump it up 1 mg in hope it works without the same level of side effects I had when I first started.

 

[lessthanhalf]

I started by following the studies at 2mg and truthfully it hit me like a ton of bricks. No appetite, sleep was awful, constipation. But the last week and a half I feel the food noise coming back so I’m just going to bump it up 1 mg in hope it works without the same level of side effects I had when I first started.

I think this is exactly the situation where following the trial dosing protocol is a bad idea and going up very slowly is a good idea. If you have side effects at low doses , and you want to increase doses after the side effects fade a bit, then going up a tiny bit at a time like 1mg is exactly the right approach. Or split dosing if the side effects are only an issue for a day or 2 after each dose. If you don't have side effects I do not think going super low or slow is needed.

 

[SVT810E]

Do people really do this? I tried mk677 before and holy shit I could eat a dinner for a family of 4 after that, it made my appetite go insane. Is it not this way with other secretagogues?

There’s two types of secretagogues.

You have growth hormone releasing hormone (GHRH aka GRF) receptor agonists like tesamorelin, sermorelin, and CJC-1295. These can have a modest effect on appetite (because growth hormone has a modest effect on appetite) but they tend to be weight neutral (ignoring water retention) as growth hormone also increases energy expenditure.

And then you have the ghrelin receptor agonists (GHRP aka GHS) like MK-677, GHRP-2, GHRP-6, and ipamorelin. These are all targeting the ghrelin receptor which has profound effects on appetite (ghrelin is known as the hunger hormone after all). Sometimes people will that ipamorelin doesn’t do this, that it’s a selective ghrelin agonist that doesn’t cause the primary effect of the ghrelin receptor, but you’ll hear this from people microdosing 1/20th of the clinical trial dose. They simply don’t notice much of an effect on appetite because they’re taking too small of a dose for that to happen. If you start taking several milligrams a day like they did in clinical trials your appetite will definitely respond.

 

[Tibial]

There’s two types of secretagogues.

You have growth hormone releasing hormone (GHRH aka GRF) receptor agonists like tesamorelin, sermorelin, and CJC-1295. These can have a modest effect on appetite (because growth hormone has a modest effect on appetite) but they tend to be weight neutral (ignoring water retention) as growth hormone also increases energy expenditure.

And then you have the ghrelin receptor agonists (GHRP aka GHS) like MK-677, GHRP-2, GHRP-6, and ipamorelin. These are all targeting the ghrelin receptor which has profound effects on appetite (ghrelin is known as the hunger hormone after all). Sometimes people will that ipamorelin doesn’t do this, that it’s a selective ghrelin agonist that doesn’t cause the primary effect of the ghrelin receptor, but you’ll hear this from people microdosing 1/20th of the clinical trial dose. They simply don’t notice much of an effect on appetite because they’re taking too small of a dose for that to happen. If you start taking several milligrams a day like they did in clinical trials your appetite will definitely respond.

Yo thanks for the detailed response <3! This is super interesting I had no idea.

 

[diplomat]

This is the kind of info I came here for! Thanks!

 

[Bakerskibum87]

I do 9 mg of Reta and 2 mg of Cagri with 1mg AOD and got through my plateau. 260 to 198 headed to 185 then need math skills for maintenance

 

[glx3550]

I’ve hit a plateau. I’ve been on 2 mg for about 6–7 months and lost around 16 kg. I started with a higher body fat percentage, and now I’m quite lean.
The appetite suppression faded a while back, but since I had no cravings, I stayed at 2 mg while still losing weight.
In recent weeks, however, the cravings returned strongly. I increased to 5 mg for two weeks—no effect. Last week, I dropped back to 2 mg, still no change.
I’m under a structured nutrition plan and coaching, so any weight fluctuations are monitored. I’m not concerned about stopping cold turkey for a month to see how my body responds. After that, I may start again until I reach my goal of achieving a very low body fat percentage.

 

[Thee Oohwee]

I’ve hit a plateau. I’ve been on 2 mg for about 6–7 months and lost around 16 kg. I started with a higher body fat percentage, and now I’m quite lean.
The appetite suppression faded a while back, but since I had no cravings, I stayed at 2 mg while still losing weight.
In recent weeks, however, the cravings returned strongly. I increased to 5 mg for two weeks—no effect. Last week, I dropped back to 2 mg, still no change.
I’m under a structured nutrition plan and coaching, so any weight fluctuations are monitored. I’m not concerned about stopping cold turkey for a month to see how my body responds. After that, I may start again until I reach my goal of achieving a very low body fat percentage.

From what I've learned about Tirz and Reta is that you have to give it some time in your body to adjust to those levels. Clearly, you plateaued at 2mg and moved it up to 5mg - but only for two weeks. Not nearly enough time for it to build up to therapeutic levels in your body. Give it at least 4 weeks - then see how you're feeling.

Personally, I am moving from Tirz to Reta. I'm titrating Reta up while I take Tirz down. I pin three days apart. I'm keeping a small dose of Tirz right now just to help with food noise suppression until I get the levels of Reta up in my body. I hope this makes sense, but this has been my approach, and I hope it helps.

 

[Habibibi]

I’ve hit a plateau. I’ve been on 2 mg for about 6–7 months and lost around 16 kg. I started with a higher body fat percentage, and now I’m quite lean.
The appetite suppression faded a while back, but since I had no cravings, I stayed at 2 mg while still losing weight.
In recent weeks, however, the cravings returned strongly. I increased to 5 mg for two weeks—no effect. Last week, I dropped back to 2 mg, still no change.
I’m under a structured nutrition plan and coaching, so any weight fluctuations are monitored. I’m not concerned about stopping cold turkey for a month to see how my body responds. After that, I may start again until I reach my goal of achieving a very low body fat percentage.

You need to stay at a set dosage for at least 4 weeks to see how it affects you.