RHR and Retatrutide

[wkndworrier]

Hi All,

Background: I’ve been running a low dose of either Sema or Tirz (.25mg and 1.25mg respectively) for the last year with the aim to slightly improve body comp and lower A1C. I lost about 10lbs of fat (currently at 18% BF) and got to 5.0 from 5.5 A1C. I didn’t push the dose because I was worried about muscle loss and other potential negative sides.

I read about Retatrutide and decided to jump in with both feet. I’ve initially just purchased a single vial from a known US source with all the right COAs. I’m hoping to get to and maintain low teens BF%.

I’m only on my second week - I did .5mg MWF the first week and then started once weekly dosing @ 2mg the second and plan on staying there until week five. I’m aware that Retatrutide can take a few weeks to start working, however I have seen ZERO impact to my heart rate. I wear an Oura ring. I immediately saw a sustained 10pt increase on both Sema and Tirz.

I realize Reta might require some patience, but does this potentially mean I bought junk? Wondering if I should procure another single vial and try that for my 3rd weekly dose vs waiting.

Thanks!

 

[exploitedworkerbee]

2mg is just a dose to get your body used to the compound, you’re unlikely to be see any effects from it. Follow the titration schedule and see where it takes you. Many people don’t have the rhr increase at all so try not to fixate on it. This is a marathon not a sprint.

 

[wkndworrier]

Appreciate the feedback. The reason I ask is that I saw the immediate RHR increase on the other GLP-1s before “feeling” anything else.

 

[janedoe]

I switched to Reta (induction dose), from 5 months max 15mg Tirz. My RHR on Reta for first week was about 100, which was crazy at first. However, my RHR on Tirz was always high 80s- mid 90s.
Still on reta for maintenance, and my RHR is stable in the mid 70s most days, which is lower than it ever was on Tirz for 1 year.
Just depends.

 

[Bourbaki1729]

Here is my RHR data over the past 6 months. I started tirz the 3rd week of April and switched to reta the 2nd week of June. Currently taking 6mg weekly. I haven't physically noticed a difference, but the previous 2 years my RHR has all been <50.

 

[wkndworrier]

View attachment 8128
Here is my RHR data over the past 6 months. I started tirz the 3rd week of April and switched to reta the 2nd week of June. Currently taking 6mg weekly. I haven't physically noticed a difference, but the previous 2 years my RHR has all been <50.

Very helpful. So it looks like your RHR didn't see any significant change during Reta until you started titrating up? Do you recall your dosing schedule to get up to 6mg?

 

[wkndworrier]

I switched to Reta (induction dose), from 5 months max 15mg Tirz. My RHR on Reta for first week was about 100, which was crazy at first. However, my RHR on Tirz was always high 80s- mid 90s.
Still on reta for maintenance, and my RHR is stable in the mid 70s most days, which is lower than it ever was on Tirz for 1 year.
Just depends.

You are still and have been doing 2mg per week?

 

[Bourbaki1729]

Very helpful. So it looks like your RHR didn't see any significant change during Reta until you started titrating up? Do you recall your dosing schedule to get up to 6mg?

When i switched, I replaced 5mg tirz with 4mg reta for 2 weeks, 5mg for 3 weeks, and have been at 6mg for 3 weeks.

 

[peptidepower77]

Appreciate the feedback. The reason I ask is that I saw the immediate RHR increase on the other GLP-1s before “feeling” anything else.

I've been the same, tirz raises my HR, reta so far hasn't seemed to.

 

[BooneDonk]

I've been the same, tirz raises my HR, reta so far hasn't seemed to.

No increase in RHR for me on Reta. Have no experience with Tirz

 

[hexagonal]

Tirz raised my heart rate some, reta raised it a lot.

I'd be surprised if tirz increased your RHR but reta did not at therapeutic doses. It impacts the sympathetic nervous system the same way tirz does, and the glucagon receptor activation is an additional mechanism for increased RHR.

But 2mg is a low dose.

 

[peptidepower77]

Tirz raised my heart rate some, reta raised it a lot.

I'd be surprised if tirz increased your RHR but reta did not at therapeutic doses. It impacts the sympathetic nervous system the same way tirz does, and the glucagon receptor activation is an additional mechanism for increased RHR.

But 2mg is a low dose.

Not sure. I tested this batch myself too, so I know it's good. But I'm only four weeks in, maybe it will start increasing over time.